When active substance and target protein "embrace" each other
Many anti-cancer drugs block signals in cancer cells that help degenerated cells to multiply uncontrollably and detach from tissue. For example, blocking the signaling protein FAK, a so-called kinase, causes breast cancer cells to become less mobile.....»»
Carving into carbonates on Mars
This past week on Mars, Perseverance made a pit stop near Overlook Mountain to abrade a rock called Old Faithful Geyser. This target is situated within the Western side of the Margin Unit, an area around the upper edge of Jezero Crater that is astrob.....»»
How a protein component of nuclear pore complexes regulates development of blood cells, contributes to myeloid disorders
Nuclear pore complexes (NPCs) are channels composed of multiple proteins that ferry molecules in and out of the nucleus, regulating many critical cellular functions, such as gene expression, chromatin organization and RNA processes that influence cel.....»»
Researchers discover how nature repurposes ammonium transporters as receptors
A team led by Freiburg biochemist Prof. Dr. Susana Andrade has characterized a new membrane protein that allows microorganisms to repurpose ammonium transporters (Amts) as receptors......»»
Climate records keep getting shattered. Here is what you need to know
Month after month, global temperatures are setting new records. Meanwhile, scientists and climate policymakers warn of the growing likelihood that the planet will soon exceed the warming target set at the landmark Paris 2015 climate talks......»»
TikTok Hackers Target Paris Hilton, CNN, and More. What to Know About the Cyberattack
Hackers have targeted several high-profile TikTok accounts, including that of reality TV star Paris Hilton and CNN. Hackers have targeted several high-profile TikTok accounts, including that of reality TV star Paris Hilton, media co.....»»
Every color AirPods Max has a $49 discount right now
Every color of the Apple AirPods Max are down to $500 from Amazon, following a $49 discount on the wireless headphones that feature active noise cancellation......»»
Fountain of youth for plants: E3 ligase"s role in leaf longevity
A recent study uncovers the intricate molecular mechanisms that regulate leaf senescence in apple plants, focusing on the crucial role of the E3 ligase enzyme, MdPUB23, and its interaction with the ABI5 protein. This research provides valuable insigh.....»»
Blood sausages and yak milk: Bronze Age cuisine of Mongolian nomads unveiled
Bronze cauldrons were used by the inhabitants of the Mongolian steppe around 2,700 years ago to process animal blood and milk. This is shown by a protein analysis of archaeological finds from this period......»»
"The Substance" review: Demi Moore dazzles in a derivative midnight snooze
At last, Cannes embraces body-horror schlock in Coralie Fargeat's "The Substance," but the film is more metaphorical than meaningful. Review. "Have you ever dreamt of a better version of yourself?" asks The Substance. Repeated like a ritualisti.....»»
Carbon capture must quadruple by 2050 to meet climate targets: Report
By 2050, humanity must durably remove four times as much CO2 from the air as today to cap global warming below the crucial target of two degrees Celsius, researchers said Tuesday......»»
Investors underestimated risk, impact of hurricanes prior to feeling "Superstorm" Sandy"s fury on Wall Street
Weather experts are warning that this year's Atlantic hurricane season, which officially began June 1, could be among the most active on record. Hurricanes annually cause millions of dollars in damage to households and public infrastructure, but also.....»»
Researchers discover disordered clock protein that sheds new light on circadian rhythms
Circadian clocks, which drive circadian rhythms, are entwined with many essential systems in living things including plants, fungi, insects, and even humans. Because of this, disruptions to our circadian clocks are linked to higher disease rates in h.....»»
Researchers develop instrument to measure lava viscosity in the field
Millions of people live near active volcanoes that are constantly monitored for signs of an impending eruption. When one occurs, scientists and governments rely on data to estimate the extent of the possible damage, informing evacuation plans and dis.....»»
Microsoft’s hallmark AI feature dubbed a security disaster just days away from Apple’s privacy-focused AI launch at WWDC
Microsoft has a target on Apple’s back with its AI-centric Copilot Plus PC models. When the computers were announced, the company repeatedly claimed that they outperformed the latest M3 MacBook Airs. Today a new ad campaign sought to further entice.....»»
Best Buy just knocked $80 off the Bose QuietComfort Earbuds II
The Bose QuietComfort Earbuds II with active noise cancellation and an IPX4 water and sweat resistance rating are down to $199 from Best Buy for $80 in savings......»»
NASA sets new target launch date for Starliner spacecraft
Following the dramatic halt to proceedings just minutes before liftoff on Saturday, NASA has now shared a new target launch date for the Starliner spacecraft......»»
The iPhone 16’s biggest selling point may not be the phone itself, but AI features in iOS 18
Days out from WWDC and the AI rumor mill is active as ever. Yesterday Mark Gurman reported that many of iOS 18’s AI features will require using an iPhone 15 Pro or later. It’s rare for many major software features to be exclusive to the latest.....»»
Check Point VPN zero-day exploited since beginning of April (CVE-2024-24919)
Attackers have been exploiting CVE-2024-24919, a zero-day vulnerability in Check Point Security Gateways, to pinpoint and extract password hashes for local accounts, which they then used to move laterally in the target organizations’ network. &.....»»
Virtual flying lessons for Hera asteroid mission
As ESA's Hera spacecraft for planetary defense goes through pre-flight testing, the system that will steer it around its target binary asteroid system is also undergoing its final checks for space......»»
Sleight of hand: Australia"s Net Zero target is being lost in accounting tricks, offsets and more gas
In announcing Australia's support for fossil gas all the way to 2050 and beyond, Prime Minister Anthony Albanese has pushed his government's commitment to net zero even further out of reach......»»