When active substance and target protein "embrace" each other
Many anti-cancer drugs block signals in cancer cells that help degenerated cells to multiply uncontrollably and detach from tissue. For example, blocking the signaling protein FAK, a so-called kinase, causes breast cancer cells to become less mobile.....»»
Companies in strategic alliances get better access to financing and more desirable terms, research shows
Shoppers browsing through blouses and blenders at Target know they can also quaff a cappuccino at one of more than 1,700 Starbucks cafeshoused within Targets. The strategic alliance benefits both corporations by helping them reach new markets, boost.....»»
Bats use four key tactics for accurate target tracking
The ability of "target tracking," i.e., keeping a target object in sight, is essential for various activities and has improved in animals and machines through the evolution of life and technology, respectively. Because most sensing systems are inevit.....»»
Researchers discover MAPK20-ATG6 link in tomato pollen vitality
Pollen development in flowering plants is a complex process involving multiple genetic and physiological pathways. Previous studies have highlighted the importance of mitogen-activated protein kinases (MAPKs) in various plant developmental stages......»»
Quantum state mixing in photobiology: New insight from ultrafast terahertz Stark spectroscopy
The membrane protein bacteriorhodopsin is a proton pump, in which proton transport is initiated by the light-induced isomerization of the chromophore retinal. The molecular quantum states involved in this ultrafast reaction have now been characterize.....»»
New fluorescent reporting system illuminates accumulation of unfolded proteins in endoplasmic reticulum
The endoplasmic reticulum (ER) is a major organelle responsible for protein folding and trafficking. Protein folding stress in the ER can lead to the accumulation of unfolded or misfolded proteins, known as ER stress, which activates the unfolded pro.....»»
Zeek: Open-source network traffic analysis, security monitoring
Zeek is an open-source network analysis framework. Unlike an active security device such as a firewall, Zeek operates on a versatile ‘sensor’ that can be a hardware, software, virtual, or cloud platform. This flexibility allows Zeek to qu.....»»
SharePlay in Apple Music gets more shareable in iPadOS 18
Apple has upgraded SharePlay when dealing with Apple Music in iPadOS 18, but only when connected to supported external devices like HomePods and select speakers.SharePlay with Apple Music gets an upgrade in iPadOS 18Having an active SharePlay session.....»»
AI-based approach matches protein interaction partners
Proteins are the building blocks of life, involved in virtually every biological process. Understanding how proteins interact with each other is crucial for deciphering the complexities of cellular functions, and has significant implications for drug.....»»
Beyerdynamic launches its first open-ear earbuds
The German audio brand Beterdynamic has released the Verio 200, a set of open-ear earbuds targeted at active lifestyles......»»
Florida conchs are in hot water: Can moving them deeper revive a plunging population?
The rescue mission began with a splash. Flippered and masked snorkelers rolled off a boat anchored near Marathon and into chest-high water. It didn't take long to spot the target......»»
Biophysicists decipher functionality of adrenaline-binding receptor
G protein-coupled receptors (GPCRs) are found throughout the human body and are involved in many complex signaling pathways. Despite their importance in many biological processes, the central mechanism of G protein-coupling and the associated signal.....»»
Dietary sucrose determines activity of lithium on gene expression and lifespan in D. melanogaster
The amount of dietary sugars and the administration of lithium both impact the lifespan of the fruit fly Drosophila melanogaster. It is noteworthy that lithium is attributed with insulin-like activity as it stimulates protein kinase B/Akt and suppres.....»»
Scammers target dealerships in U.S., Canada pretending to be CDK reps
CDK Global says scammers are targeting some dealership customers affected by the cyberattack that downed their DMS platforms......»»
An efficient protein delivery system with spider minor ampullate silk protein nanoparticles
In a study published in the journal MedComm, researchers have developed an efficient protein delivery carrier based on spider silk proteins (spidroins), derived from Araneus ventricosus minor ampullate silk protein (MiSp). The MiSp-based nanoparticle.....»»
New insights into how cell shape influences protein transport rates
When a cell spreads out or changes its shape to adapt to its environment, the transport rate of proteins between the nucleus and cytoplasm changes. Previously, scientists assumed this change was caused by a shift in the size of the nuclear envelope's.....»»
Study reveals molecular mechanisms of somatostatin receptor 5 activation by neuropeptides and drugs
Somatostatin receptors (SSTRs) constitute a crucial family of G protein-coupled receptors (GPCRs) that play pivotal roles in regulating hormone secretion and inhibiting tumor growth......»»
Why advertisers pay more to reach viewers who watch less
A new study finds that viewers' income and likelihood of buying a product are not the factors that determine how much it costs to reach them— it's how active they are on the platforms where the ads run......»»
Researchers find wave activity on Titan may be strong enough to erode the coastlines of lakes and seas
Titan, Saturn's largest moon, is the only other planetary body in the solar system that currently hosts active rivers, lakes, and seas. These otherworldly river systems are thought to be filled with liquid methane and ethane that flows into wide lake.....»»
US DOJ sues Adobe for ‘trapping’ users in subscriptions
Adobe is the latest target of the US Department of Justice’s recent wave of high-profile lawsuits. The company’s subscription cancellation practices are the specific target of the DOJ, which the government says is tantamount to ‘trapping’ use.....»»
JP Morgan raises Apple stock target to $245 on AI announcements
Analysts at JP Morgan say that Apple's launch of AI features will prompt users to upgrade their iPhones, and has raised the price target by $20.JP Morgan has raised its Apple price targetJP Morgan has previously expected that Apple's AI features woul.....»»