Unfolding the blindness proteins through fly eyes
Every 6 minutes someone is told they're going blind. One of the major causes of human blindness is a disease called Retinitis Pigmentosa (RP), which causes progressive degeneration of the retina and vision loss. Approximately one-tenth of Retinitis.....»»
"Australia is sleepwalking": A bushfire scientist explains what the Hawaii tragedy means for our flammable continent
As I hear reports of the fire tearing through the Hawaiian island of Maui, I feel utterly depressed. As a fire scientist, I know the unfolding horror—which has killed 36 people so far—is just the beginning. It's a portent of what Australia and ot.....»»
Glucagon receptor structures uncover new arrestin interaction mechanism
G protein-coupled receptors (GPCRs) are essential for cell signal transduction and constitute the largest drug target protein family. Upon agonist stimulation, these receptors activate multiple downstream transducers, including G proteins and arresti.....»»
Apple Vision Diary: Trying virtual Mac monitors on the Quest 2
While some rolled their eyes when Apple described Vision Pro as a spatial computer, instead of a headset, I didn’t. That’s because, to me, having virtual Mac monitors in front of my eyes, no matter where I am, is by far the most exciting use case.....»»
The "unknome": A database of human genes we know almost nothing about
Researchers from the United Kingdom hope that a new, publicly available database they have created will shrink, not grow, over time. That's because it is a compendium of the thousands of understudied proteins encoded by genes in the human genome, who.....»»
Top 12 vulnerabilities routinely exploited in 2022
Cybersecurity agencies from member countries of the Five Eyes intelligence alliance have released a list of the top 12 vulnerabilities routinely exploited in 2022, plus 30 additional ones also “popular” with attackers. The top 12 “I.....»»
New strategy decodes dynamic structure of proteins within cells
Protein dynamics play a crucial role in diverse functions. The intracellular environment significantly influences protein dynamics, particularly for intrinsically disordered proteins (IDPs)......»»
Deep learning for new protein design
The key to understanding proteins—such as those that govern cancer, COVID-19, and other diseases—is quite simple: Identify their chemical structure and find which other proteins can bind to them. But there's a catch......»»
Where to watch Lollapalooza 2023 live stream
All eyes will be on Chicago this weekend for the iconic music festival, Lollapalooza 2023. Find out how to stream the event......»»
Patchwork of Wnt signaling ligands and receptors pattern the wings of butterflies, researchers discover
Wnt signaling is a well-known mode of cell-to-cell communication in multicellular biological organisms. It involves the secretion of small Wnt glycoproteins, by signaling cells, that bind to receptor proteins in the membrane of receiving cells. This.....»»
Blue light: An on-off switch for enzymes
Light affects living organisms in many different ways, for example, plants orient their growth direction towards the sun, while circadian rhythms in humans are controlled by daylight. These processes always involve photoreceptors, which are proteins.....»»
Biological origami at molecular level: Cytosolic interactome protects against protein unfolding
Human cells are protecting their proteins from unfolding and aggregating. That's what biophysicist Alireza Mashaghi and his team discovered after seven years of in-depth research into the folding mechanisms of proteins. With an unprecedented approach.....»»
Antarctica is missing a chunk of sea ice bigger than Greenland. What"s going on?
Deadly heatwaves, raging wildfires and record global temperatures are upon us. But far from the flames, at the southernmost tip of the planet, something just as shocking is unfolding......»»
Retina cells cultured on nanofiber scaffolds could help treat blindness
Scientists have found a way to use nanotechnology to create a 3D "scaffold" to grow cells from the retina—paving the way for potential new ways of treating a common cause of blindness......»»
New "protein nano-switch" method promises rapid and reliable development of diagnostic tests
QUT researchers have developed a new approach for designing molecular ON-OFF switches based on proteins which can be used in a multitude of biotechnological, biomedical and bioengineering applications......»»
Your genetic code has lots of "words" for the same thing—information theory may help explain the redundancies
Nearly all life, from bacteria to humans, uses the same genetic code. This code acts as a dictionary, translating genes into the amino acids used to build proteins. The universality of the genetic code indicates a common ancestry among all living org.....»»
Researchers investigate how the cellular environment affects protein conformational dynamics
Protein dynamics through motions of loops, linkers, and hinges can generate distinctive conformations that are important for protein function. Most proteins perform their functions in cells. However, how the complex cellular environment affects the c.....»»
You have to see the original Twisted Metal’s lost live-action endings
The new Twisted Metal show isn't the series' first foray into live-action. Feast your eyes on the PS1 original's bizarre lost endings......»»
Breakthrough in solid-state storage innovates how biological materials are stored and handled
Scientists have developed a novel method for storing biological materials such as RNA and proteins in a solid-state. The storage in solid-state resembles the form of a pill or a tablet, which dissolves in water for on-demand use. The innovation provi.....»»
Nissan eyes exporting more from China as sales slump
CEO Makoto Uchida says Nissan had not yet decided on an export plan or determined a target market for China-made product. But he says Nissan must consider emergency measures to boost business in China, where sales slumped 46 percent in the quarter......»»
AMG-1/SLRP-1 is required for spermatogenesis in C. elegans: Study
The mechanisms of RNA-binding proteins (RBPs)-mediated post-transcriptional regulation of pre-existing mRNAs, which is essential for spermatogenesis, remain poorly understood......»»