Suffering from psoriasis? Blame this trio of proteins
About 7.5 million Americans suffer from psoriasis, an autoimmune disease that shows up as patches of red, inflamed skin and painful, scaly rashes. Although there are effective treatments for psoriasis, not everyone responds to these therapies -- and.....»»
Streaming bundle of Apple TV+, Netflix and Peacock announced, ‘vastly reduced’ price promised
The trio of Apple TV+, Netflix and Peacock are to be packaged in a new streaming TV bundle option, as teased by Comcast CEO Brian Roberts at a conference today. More details about the bundle offering will be revealed later this month, but Roberts.....»»
Research shows that "softer" proteins can cross into the nucleus quicker
Researchers at the Francis Crick Institute and King's College London have discovered that how soft or rigid proteins are in certain regions can dictate how fast or slow they enter the nucleus......»»
AI may be to blame for our failure to make contact with alien civilizations
Artificial intelligence (AI) has progressed at an astounding pace over the last few years. Some scientists are now looking towards the development of artificial superintelligence (ASI)—a form of AI that would not only surpass human intelligence but.....»»
Team develops an epigenome editing toolkit to dissect the mechanisms of gene regulation
Understanding how genes are regulated at the molecular level is a central challenge in modern biology. This complex mechanism is mainly driven by the interaction between proteins called transcription factors, DNA regulatory regions, and epigenetic mo.....»»
New technology changes how proteins in individual cells are studied
Researchers from Karolinska Institutet, together with Pixelgen Technologies, have developed and applied a technique that makes it possible to map proteins in individual cells in a completely new way. Not only is it now possible to measure the amount.....»»
Scientists use high pressure NMR spectroscopy to study structure of dynamic proteins
A pressure of 3,000 bar is applied to the cold shock protein B of Bacillus subtilis in a small tube in the NMR spectroscopy laboratory at the University of Konstanz. This is roughly three times the water pressure at the deepest point of the ocean. Th.....»»
Novel chemical tool for understanding membrane remodeling in the cell
In a study published in Proceedings of the National Academy of Sciences, Umeå researchers describe a natural product-like molecule, Tantalosin, that inhibits interaction between two proteins in complexes that reshape membranes inside the cell......»»
Mass fish die-off in Vietnam as heat wave roasts Southeast Asia
Hundreds of thousands of fish have died in a reservoir in southern Vietnam's Dong Nai province, with locals and media reports suggesting a brutal heat wave and the lake's management are to blame......»»
Motherboard makers apparently to blame for high-end Intel Core i9 CPU failures
Motherboard makers "disable thermal and power delivery safeguards" by default. Enlarge / Intel's top-end i9-14900KS. (credit: Intel) Earlier this month, we wrote that some of Intel's recent high-end Core i9 and Core i7.....»»
Microgravity-grown crystals reveal new insights into protein structures
Biochemists have long been working around a blind spot when it comes to proteins. They know that hydrogen constitutes nearly half of the atoms in proteins, but how they contribute to protein function in these complex structures has been less clear. H.....»»
Researchers decipher how an enzyme modifies the genetic material in the cell nucleus
Inside the cell nucleus, the DNA molecule is found in a densely packed DNA-protein complex known as chromatin. Here the DNA is wrapped around a core of histone proteins and densely packed to form nucleosomes. The structure of the nucleosomes determin.....»»
A systematic review of three key sugar metabolism proteins: HXK, SnRK1 and TOR
Sugar signaling is one of the most important regulatory signals for plant growth and development, and its metabolic network contains many regulatory factors. Sugar signaling molecules regulate cellular activities and organismal development by interac.....»»
A shortcut for drug discovery: Novel method predicts on a large scale how small molecules interact with proteins
For most human proteins, there are no small molecules known to bind them chemically (so-called "ligands"). Ligands frequently represent important starting points for drug development but this knowledge gap critically hampers the development of novel.....»»
Researchers create artificial cells that act like living cells
In a new study published in Nature Chemistry, UNC-Chapel Hill researcher Ronit Freeman and her colleagues describe the steps they took to manipulate DNA and proteins—essential building blocks of life—to create cells that look and act like cells f.....»»
Supercomputer simulation reveals new mechanism for membrane fusion
An intricate simulation performed by UT Southwestern Medical Center researchers using one of the world's most powerful supercomputers sheds new light on how proteins called SNAREs cause biological membranes to fuse......»»
Researchers report on mechanisms of gene regulatory divergence between species
Closely related animal species can look physically different, but you might be surprised to learn that those differences can result not only from DNA sequence changes that alter proteins' structure or function, but also because changes in the DNA aff.....»»
Don"t blame Dubai"s freak rain on cloud seeding—the storm was far too big to be human-made
Some years ago, I found myself making my way up the narrow stairs of a Learjet on a sultry runway in a deserted airport near the South Africa-Mozambique border. The humidity was there to taste—the air thick with it......»»
Researchers map protein network dynamics during cell division
An international team led by researchers at the University of Toronto has mapped the movement of proteins encoded by the yeast genome throughout its cell cycle. This is the first time that all the proteins of an organism have been tracked across the.....»»
Australia"s Great Barrier Reef struggles to survive
Australia's famed Great Barrier Reef is suffering one of the most severe coral bleaching events on record, leaving scientists fearful for its survival as the impact of climate change worsens......»»
Light show in living cells: New method allows simultaneous fluorescent labeling of many proteins
Observing proteins precisely within cells is extremely important for many branches of research but has been a significant technical challenge—especially in living cells, as the required fluorescent labeling had to be individually attached to each p.....»»