Structure-destabilizing mutations transform Bcl-2 from an antiapoptotic protein into a proapoptotic protein
Bcl-2 family proteins are highly conserved molecules that play a crucial role in regulating the release of apoptotic proteins from mitochondria. They possess Bcl-2 homology (BH) domains, which are characterized by both sequence and structural similar.....»»
Protein structure and design software gets the Chemistry Nobel
One academic and two people from DeepMind take home the Nobel. On Wednesday, the Nobel Committee announced that it had awarded the Nobel Prize in chemistry to researchers who pion.....»»
Nobel Prize in chemistry awarded to 3 scientists for work on proteins, building blocks of life
The Nobel Prize in chemistry was awarded Wednesday to three scientists for their breakthrough work predicting and even designing the structure of proteins, the building blocks of life......»»
New global database of dams and reservoirs could transform water management
A database developed by the Global Dam Watch (GDW) consortium is set to transform the global understanding of dams and reservoirs......»»
Nanopore technique shows transport mechanism of chaperone proteins at the single-molecule level
Proteins control most of the body's functions, and their malfunction can have severe consequences, such as neurodegenerative diseases or cancer. Therefore, cells have mechanisms in place to control protein quality......»»
Research team develops metallodrug-antibiotic combination strategy to combat superbugs
Antimicrobial resistance (AMR) bacterial infections have become a serious problem threatening human health worldwide. The overuse of antibiotics has promoted drug-resistant mutations in bacteria, causing almost all clinically used antibiotics to deve.....»»
Ars Prime Day 2024 Techstravaganza: The best deals on the best things
Tech deals, gaming deals, accessory deals—all the deals in one place! Get ready to transform and roll out, Arsians: It's Prime Day! Named in honor of famous Autobot leader Optim.....»»
Meet the microbes that transform toxic carbon monoxide into valuable biofuel
Microbes are hungry, all the time. They live everywhere, in enormous numbers. We might not see them with the naked eye, but they are in soils, lakes, oceans, hydrothermal vents, our homes, and even in and on our own bodies. And they don't just hang o.....»»
Cellular agriculture research manages to culture pork fat tissue on rye protein scaffolds
National University of Singapore (NUS) food scientists have developed a simple and scalable method for culturing pork fat tissue using protein scaffolds made from secalin, a protein extracted from rye......»»
Scientists find plant-like behavior in human cells
A team of scientists from Monash University has solved the structure of a protein known as "LYCHOS," which can detect and regulate cell growth by sensing cholesterol levels in the body......»»
Ancient protein structure may have enabled early molecular evolution and diversification
In a finding that offers fresh insights into the early evolution of life on Earth, two RIKEN biologists have conducted lab experiments that have revealed a previously unknown protein fold, which is completely absent in modern proteins......»»
Filament structure found to activate and regulate CRISPR-Cas "protein scissors"
CRISPR-Cas systems help to protect bacteria from viruses. Several different types of CRISPR-Cas defense systems are found in bacteria, which differ in their composition and functions. Among them, the most studied proteins today are Cas9 and Cas12, al.....»»
Protein involved in the early stages of age-related macular degeneration offers hope for prevention
Age-related macular degeneration (AMD) is a leading cause of irreversible vision loss in the United States. Despite existing treatments, the underlying causes of this disease and effective therapies remain elusive. Research published in the journal D.....»»
Researchers determine how a protein contributes to human immune defense against RNA viruses
An international research team led by Prof. Dr. Janosch Hennig from the University of Bayreuth has discovered how the TRIM25 protein contributes to defense against RNA viruses whose genetic material is contained as ribonucleic acid (RNA)......»»
Ring Protect rebrands to Ring Home and adds 24/7 recording
Ring Protect is now Ring Home, and while its pricing structure is the same, it benefits from several cool new features -- including 24/7 recording......»»
Seeing double: Designing drugs that target "twin" cancer proteins
Some proteins in the human body are easy to block with a drug; they have an obvious spot in their structure where a drug can fit, like a key in a lock. But other proteins are more difficult to target, with no clear drug-binding sites......»»
3D structure of key protein could advance development of hormone-free male contraceptive pill
Melbourne-based scientists behind the development of a hormone-free, reversible male contraceptive pill have, for the first time, solved the molecular structure of the discovery program's primary therapeutic target, significantly increasing the chanc.....»»
DNA nanotechnology unravels complex protein interactions to inform cancer diagnostics
A team of researchers from NUS Institute for Health Innovation & Technology (iHealthtech), led by Associate Professor Shao Huilin and Associate Professor Brian Lim, has developed a first-of-its-kind technology to map out diverse protein interactions.....»»
Protein study reveals how the tiny shrew achieves a resting heart rate of 1,020 beats per minute
The shrew's resting heart rate can reach up to 17 beats per second, equivalent to about 1,020 beats per minute. In comparison, the average human resting heart rate is around 60 to 100 beats per minute, making the shrew's resting heart rate approximat.....»»
Geologists discover mysterious subduction zone beneath Pacific, reshaping understanding of Earth"s interior
University of Maryland scientists uncovered evidence of an ancient seafloor that sank deep into Earth during the age of dinosaurs, challenging existing theories about Earth's interior structure. Located in the East Pacific Rise (a tectonic plate boun.....»»
Trimer complex TaNF-Y balances grain yield and quality in wheat: Study
Breeding efforts have focused intensively on improving grain yield and quality in wheat (Triticum aestivum L.). Content and composition of grain starch and seed storage protein (SSP) are two critical factors that determine grain yield and quality. St.....»»