Structure-destabilizing mutations transform Bcl-2 from an antiapoptotic protein into a proapoptotic protein
Bcl-2 family proteins are highly conserved molecules that play a crucial role in regulating the release of apoptotic proteins from mitochondria. They possess Bcl-2 homology (BH) domains, which are characterized by both sequence and structural similar.....»»
Genome sequencing could unlock answers to yellow jacket behavior
The most recognizable yellow jacket at Georgia Tech is made of fabric and foam, but Professor Mike Goodisman and a team of researchers revealed a far more complex cellular structure by successfully sequencing the genome of two local species of yellow.....»»
Scientists discover chemical probes for previously "undruggable" cancer target
Hormone-driven cancers, like those of the breast and prostate, often rely on a tricky-to-target protein called Forkhead box protein 1 (FOXA1). FOXA1 mutations can enable these types of cancers to grow and proliferate. Today, FOXA1 is notoriously diff.....»»
Spin-wave reservoir chips can enhance edge computing
Reservoir computing (RC) has a few benefits over other artificial neural networks, including the reservoir that gives this technique its name. The reservoir functions mainly to nonlinearly transform input data more quickly and efficiently. Spin waves.....»»
Canopy structure regulates autumn phenology by mediating microclimate in temperate forests, finds study
Autumn phenology serves as a sensitive indicator of temperate forests' response to climate change and is a key factor influencing forest carbon sequestration. Understanding the mechanisms driving the spatiotemporal variations in autumn phenology is c.....»»
Glowing proteins enable real-time, 3-D study of essential enzymes
Working in organoid models, researchers at University of California San Diego School of Medicine have developed a new tool to study protein-kinase C (PKC) enzymes, which play a critical role in cell growth, differentiation and survival. Malfunction o.....»»
Calcium transport protein in bacteria offers insights for drug development and food safety
Researchers at Umeå University have revealed details on how bacteria use calcium to regulate vital processes in a way that differs from human cells. This breakthrough is significant in the fight against antibiotic resistance and for increasing safet.....»»
Protein USP50 identified as key in DNA replication balance
A protein that is involved in determining which enzymes cut or unwind DNA during the replication process has been identified in a new study......»»
Expansion in situ genome sequencing innovation makes hidden DNA-protein interactions visible
Harvard scientists have unveiled a new technique called expansion in situ genome sequencing (ExIGS) that combines existing in situ genome sequencing (IGS) with expansion microscopy (ExM). The innovation allowed researchers to link nucleus abnormaliti.....»»
Machine learning cracked the protein-folding problem and won the 2024 Nobel Prize in chemistry
The 2024 Nobel Prize in chemistry recognized Demis Hassabis, John Jumper and David Baker for using machine learning to tackle one of biology's biggest challenges: predicting the 3D shape of proteins and designing them from scratch......»»
MKBHD continues to slowly try and fix the Panels app
A beloved tech YouTuber released a video addressing fans' concerns and promising to improve the pricing structure and permission requirements of his app......»»
Targeting "undruggable" diseases: Researchers reveal new levels of detail in targeted protein degradation
Researchers at the University of Dundee have revealed in the greatest detail yet the workings of molecules called protein degraders which can be deployed to combat what have previously been regarded as "undruggable" diseases, including cancers and ne.....»»
Oxidative stress: How protein recycling protects against cell death
Researchers at LMU University Hospital have discovered a new molecular switch that protects against cell death......»»
Scientists discover how innate immunity envelops bacteria
The protein GBP1 is a vital component of our body's natural defense against pathogens. This substance fights against bacteria and parasites by enveloping them in a protein coat, but how the substance manages to do this has remained unknown until now......»»
Astronomers find Webb data conflict with reionization models
Reionization is a critical period when the first stars and galaxies changed the physical structure of their surroundings, and eventually the entire universe. Established theories state that this epoch ended around 1 billion years after the Big Bang......»»
From chaos to structure: How a bunch of seemingly disorganized cells go on to form a robust embryo
Pipetting liquids into tiny test tubes, analyzing huge datasets, poring over research publications—all these tasks are part of being a scientist. But breaking this routine is essential. Time away from the usual work environment can spark creative i.....»»
AI-driven approach challenges traditional views on protein structure
In a recently published article in Nature Communications,, a team offers an AI-driven approach to explore structural similarities and relationships across the protein universe. The team includes members from the University of Virginia—including Phi.....»»
Spectroscopy study determines how catalysts remove dangerous nitrogen oxides
Catalysts belonging to the zeolite family help to remove toxic nitrogen oxides from industrial emissions. Researchers at the Paul Scherrer Institute PSI have now discovered that their complex nano porous structure is crucial. Specifically, individual.....»»
Detailed images of key protein complexes provide new insights into bacterial photosynthesis
Researchers at the University of Liverpool and collaborators have arrived at a new understanding of bacterial photosynthesis. Using novel techniques, investigators have unveiled intricate detailed images of the key photosynthetic protein complexes of.....»»
Making micelles more effective for dye and drug dispersion through well-defined core-shell structures
Micelles are spherical molecular structures usually formed by amphiphilic molecules with block structure, which contain both hydrophilic and hydrophobic parts. The hydrophobic tails of these molecules cluster together to form a core, while the hydrop.....»»
Protein structure and design software gets the Chemistry Nobel
One academic and two people from DeepMind take home the Nobel. On Wednesday, the Nobel Committee announced that it had awarded the Nobel Prize in chemistry to researchers who pion.....»»