Structural and functional studies of adhesion receptors disclose intrinsic activation mechanism of orphan GPCRs
G protein-coupled receptors (GPCRs) play a crucial role in cell signal transduction and comprise the largest drug target protein family. Despite recent breakthroughs in structural and pharmacological studies of these receptors, more than 100 GPCRs re.....»»
High-resolution structural data shows how a supercomplex links mRNA translation and decay
Messenger RNA (mRNA) serves as a blueprint for proteins. When mRNA is no longer needed, it must be degraded. Director Elena Conti and her team at the Max Planck Institute of Biochemistry in Martinsried near Munich have now been able to show that the.....»»
In our opinion: Believe the storms: Climate change is real
No one should try to kill the auto industry in hopes of saving the planet. But we must also take seriously the need for the industry to be a functional partner in a solution......»»
What yields per acre reveal about the impact of extreme weather
Since time immemorial, crop yields have been influenced by such extreme weather phenomena as heat waves, persisting droughts, downpours and lasting rainfall. Many studies have already demonstrated that due to climate change, periods of extreme weathe.....»»
AI-driven approach challenges traditional views on protein structure
In a recently published article in Nature Communications,, a team offers an AI-driven approach to explore structural similarities and relationships across the protein universe. The team includes members from the University of Virginia—including Phi.....»»
Scientists accelerate uranium beam with record power
Scientists and engineers at the Facility for Rare Isotope Beams (FRIB) have reached a new milestone in isotope studies. They accelerated a high-power beam of uranium ions and delivered a record 10.4 kilowatts of continuous beam power to a target. The.....»»
Genetic mechanism unlocks a key secret behind disease infection in crops
Researchers have unraveled a key genetic mechanism behind the way pathogens infect crops, leading to new strategies for breeding resistant crop varieties against other pathogens carrying the same genetic mechanism......»»
Nanopore technique shows transport mechanism of chaperone proteins at the single-molecule level
Proteins control most of the body's functions, and their malfunction can have severe consequences, such as neurodegenerative diseases or cancer. Therefore, cells have mechanisms in place to control protein quality......»»
Comprehensive efforts needed to develop health-promoting learning environments, review finds
Mental ill-health among students in higher education is a growing problem globally. Most efforts implemented to address ill-health involve individual treatment and adjustments to pedagogy. But more can and needs to be done at a structural or environm.....»»
Study finds early STEM success doesn"t boost college enrollment for Black, Latine students
Research studies have consistently identified early academic disparities as the greatest barrier to STEM representation for non-white students. To address the lack of racial and ethnic diversity in STEM, education policies have sought to improve math.....»»
Detecting Planck-scale dark matter by leveraging quantum interference
While various studies have hinted at the existence of dark matter, its nature, composition and underlying physics remain poorly understood......»»
Researchers uncover new plant perception mechanism for light and heat
Researchers at the University of Bayreuth and Heinrich Heine University Düsseldorf have described a previously unknown mechanism in the perception of light and heat in plants. The results contribute to a better understanding of plant physiological p.....»»
Perseverance team revives SHERLOC instrument to help with Jezero crater discovery
In January 2024, the SHERLOC instrument aboard NASA's Mars 2020 Perseverance rover encountered a significant issue. A fault in the instrument's motor caused the dust cover and autofocus mechanism to become inoperative, putting the rover's SHERLOC Ram.....»»
Lusatia"s transformation from coal is falling short on environmental sustainability, German study finds
A total of 10.3 billion euros of federal funding and several hundred million euros of state funding have been allocated to support the structural transformation of the Lusatian coal district in Brandenburg, Germany. But are the projects targeted by t.....»»
Researchers reveal key mechanism in regulating DNA recombination
Meiotic recombination generates genetic diversity and promotes proper chromosomal segregation of parental chromosomes. This process requires a set of recombinases polymerized on single-stranded (ss) DNAs called the nucleoprotein filament to undergo h.....»»
How to install an Intel processor
Do you need to know how to install an Intel CPU? It's easier than you might think. With a little heatpaste, a functional cooler, and some steady hands, you can install an Intel CPU in just a few minutes......»»
How Soviet legacy has influenced foreign policy in Georgia and Ukraine
The legacy of the Soviet Union's collapse plays a greater role in the foreign policies of Georgia and Ukraine than previous studies have suggested. Conducting foreign policy in former Soviet countries can be a major challenge as the Russian state doe.....»»
The true global impact of species-loss caused by humans is far greater than expected, study reveals
The extinction of hundreds of bird species caused by humans over the last 130,000 years has led to substantial reductions in avian functional diversity—a measure of the range of different roles and functions that birds undertake within the environm.....»»
"Iyashikei" healing manga comforts readers with attention to small joys
Iyashikei is a Japanese genre that, according to Japanese studies scholar Paul Roquet, tells stories that are designed to comfort and heal weary readers by creating an aesthetic of calm. In order to achieve this, as Roquet articulates, these stories.....»»
Viewpoint: Indigenous students and faculty are on the rise, and universities have a moral obligation to support them
As we close out September, universities across Canada are well into their new year of learning. An exciting change is underway. An increasing number of First Nations, Inuit and Métis students have enrolled in post-secondary studies......»»
Study elucidates a mechanism for phosphorus cycling in subtropical forests
Phosphorus (P) is an important nutrient element in plant photosynthesis. However, the adsorption of mineral P via leaching and erosion leads to a decrease in P availability and consequently P deficiency......»»