Structural and biochemical basis of methylmalonate semialdehyde dehydrogenase ALDH6A1
ALDH6A1, a member of the ALDH family, plays a crucial role in the catabolic pathways of valine and thymine. Dysregulation of ALDH6A1 expression has been linked to a variety of diseases. Methylmalonate semialdehyde dehydrogenase deficiency (MMSDH defi.....»»
More academic freedom leads to more innovation, reports study
In many countries, scientists have experienced a loss of academic freedom in recent years. This trend has been criticized on the basis of fundamental principles. However, there has been no research to date on whether the degree of academic freedom al.....»»
Concerned about your early reader? Why "wait and see" isn"t advised for reading struggles
At Western University's Mary J. Wright Child and Youth Development Clinic, I work on a team training future school psychologists. In our work, we encounter parents concerned about their children's learning on an almost daily basis......»»
"Climinator" vs. greenwashers: Researcher develops AI tool to debate climate on a factual basis
Companies like to act "green" by publishing thick environmental sustainability reports replete with photography of pristine landscapes, but precious few of them keep their promises. Finance professor Markus Leippold is using AI-based tools to fight g.....»»
Unveiling the key factors that determine properties of porous polymer materials
Determining the relationship between microstructure features and their properties is crucial for improving material performance and advancing the design of next-generation structural and functional materials. However, this task is inherently challeng.....»»
macOS Sequoia adds weekly permission prompt for screenshot and screen recording apps
With macOS Sequoia this fall, using apps that need access to screen recording permissions will become a little bit more tedious. Apple is rolling out a change that will require you to give explicit permission on a weekly basis to these types of apps,.....»»
White ants: The Earth"s backboneless backbone
The first thoughts that probably come to mind when you read the words "white ant" are images of house destruction, wood damage, pest control, and spending money! While white ants are in fact a major structural and agricultural pest, they are among th.....»»
Study shows international students are not to blame for the housing crisis
There have been ongoing accusations that international students are flooding university towns and taking up all the affordable housing. These narratives paint international students as the culprit, but a new study affirms that there is no basis for b.....»»
Xbox console sales continue to crater with massive 42% revenue drop
Xbox Series X/S sales seem to have peaked early in 2022. Enlarge / The tumbling continues. Microsoft's revenue from Xbox console sales was down a whopping 42 percent on a year-over-year basis for the quarter ending in J.....»»
Breakthrough in Z-alkene synthesis: Scientists develop efficient and sustainable method
Z-alkenes are organic compounds with a double bond between two carbon atoms and two substituents attached to the carbon atoms on the same side of the double bond. They are ubiquitous structural components of organic compounds in chemistry and biology.....»»
Q&A: How machine learning is propelling structural biology
For Lucas Farnung, there is no question more fascinating than how a single fertilized egg develops into a fully-functioning human. As a structural biologist, he is studying this process on the smallest scale: the trillions of atoms that must synchron.....»»
Researchers identify structural characteristics of newly emerged SARS-CoV-2 variants
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to adapt to the herd immunity background and evolve into numerous sub-variants......»»
Almond genome study paves way for improved breeding strategies
A recent study has unlocked the genetic complexities of almonds, highlighting a significant degree of heterozygosity and the influence of structural variants on gene expression. The research rigorously delineates allele-specific expression patterns,.....»»
Restructuring middle managers—findings from a case study of a major bank
Middle managers play an important role in an organization undergoing structural change. They are the ones who must implement the changes, but conversely, as employees, they will be subject to the very changes they put in place. This can often put the.....»»
Photosynthesis powers our world, but what fuels this fundamental process?
It's hard to overstate the importance of photosynthesis, the biochemical pathway by which plants, algae, and certain bacteria convert the sun's energy into the organic material that feeds the entire living biosphere. But there are still aspects of th.....»»
Tensor-force effects on nuclear matter in relativistic ab initio theory
Tensor force is a crucial ingredient of the nucleon-nucleon (NN) interaction, and has an important impact on the structural and dynamical properties of the nuclear many-body system. Many efforts have been devoted to studying the influence of the tens.....»»
Opinion: Southern Africa is seen as a leader in wildlife conservation, but its market-driven approach is deeply flawed
Southern Africa's wildlife economy is often hailed as a successful model. The idea behind this model is that biodiversity and wildlife are used as the basis of sustainable economic growth, through an increase in wildlife numbers and in a country's re.....»»
Novel time-of-flight-resolved stimulated Raman scattering microscopy enables high-resolution bioimaging
Stimulated Raman scattering (SRS) microscopy is an optical vibrational spectroscopic imaging technique and has emerged as an appealing label-free imaging tool for tissue and cell imaging and characterization with high biochemical specificity......»»
A Chinese Space Startup Launched Its New Rocket by Accident
Space Pioneer blamed a “structural failure” for the unintended blastoff......»»
Strawberries under the high-tech magnifying glass
Sweet flavors and healthy ingredients make strawberries one of the world's most popular berries. The complex biochemical compounds that determine the flavor and nutritional value of a strawberry—known as biomarkers—can only be determined in detai.....»»
Exploring the molecular basis of how pradimicin A binds to viral N-glycan, a potential SARS-CoV-2 entry inhibitor
HIV, Ebola and most recently, COVID-19 viruses have had an enormous impact on our societies world-wide. All these viruses are "enveloped viruses," viruses that have an exterior envelope that surrounds them largely composed of their host's cells. This.....»»