Stabilizing protein drugs with a new reversible "mixing-type" material
Protein drugs are widely used as pharmaceutical agents to treat a range of disorders. However, most of these drugs are not very stable and are only retained in the blood circulation for a limited period, which minimizes their efficacy. To resolve the.....»»
Studies of migraine’s many triggers offer paths to new therapies
One class of drugs has already found success in treating the painful, common attacks. For Cherise Irons, chocolate, red wine, and aged cheeses are dangerous. So are certain sounds.....»»
The Sonos Arc Ultra might not need a separate subwoofer
With 15 amps and a new type of driver for low frequency sounds, the Sonos Arc Ultra might be the company's first soundbar that doesn't need a subwoofer......»»
Single-molecule imaging reveals aberrant DNA-binding dynamics of cancer-linked chromatin remodelers
Biophysical chemists from the National University of Singapore (NUS) have uncovered a previously hidden landscape that governs the intracellular organization and dynamics of SWI/SNF chromatin remodelers, an important class of protein complexes that c.....»»
Apple strong passwords aren’t entirely random, but are cleverly designed
Whenever an Apple device generates a strong password for you, the structure of those secure passwords isn’t entirely random. Instead, Apple created rules specifically designed to make them easier to type if you ever have to do that manually, and.....»»
Researchers find new role for protein in combating age-related diseases
McMaster University researchers have discovered a previously unknown cell-protecting function of a protein, which could open new avenues for treating age-related diseases and lead to healthier aging overall......»»
Study of wild type mosquitoes in Burkina Faso discovers new signs of insecticide resistance
One of the main discoveries of a new study is the identification of new variants in genes associated with insecticide resistance in Anopheles mosquitoes, the primary vectors of malaria in West Africa, and potential novel resistance mechanisms, emphas.....»»
Discovery of key protein for biosynthesis of plant defense steroids could enhance pest control strategies
Researchers at the Max Planck Institute for Chemical Ecology have identified GAME15 as a key protein that regulates the biosynthesis of both steroidal glycoalkaloids and steroidal saponins in plants of the genus Solanum......»»
More efficient phenotypic screening method can simultaneously test multiple drugs
Some of the most widely used drugs today, including penicillin, were discovered through a process called phenotypic screening. Using this method, scientists are essentially throwing drugs at a problem—for example, when attempting to stop bacterial.....»»
Protein signaling pathway provides insights into cell migration and cancer metastasis
The innate immune response is the body's first line of defense against infection, and a successful immune defense takes a village: a combination of physical barriers, chemical attacks, and an army of specialized white blood cells. But maintaining and.....»»
Cryo-electron microscopy sheds light on endothelin signaling mechanisms
Endothelin is a peptide hormone known for its vasoconstrictive effects. Researchers at University of Tsukuba used cryo-electron microscopy to examine the complex structure of the endothelin receptor and G protein, which are crucial for signal transdu.....»»
This Is the Best Type of Exercise if You Have a Heart Condition, According to Cardiologists
This Is the Best Type of Exercise if You Have a Heart Condition, According to Cardiologists.....»»
Second exoplanet detected orbiting an early G-type star
Astronomers report the detection of a second exoplanet orbiting a G-type star known as TIC 393818343, located some 300 light years away. The newfound alien world is about three times less massive than Jupiter. The finding was detailed in a research p.....»»
Hubble captures image of a spectacular ‘stellar volcano’
Hubble has homed in on a nearby star called R Aquarii, which is throwing out material for billions of miles around it......»»
MicroRNA, Protein Folding and Machine-Learning Work Win the Science Nobels
A roundup of the science Nobels, the latest COVID updates and the Europa Clipper launch delay......»»
First mRNA stabilizing substance could aid in development of innovative mRNA therapeutics
Messenger RNA–based therapeutics and vaccines are the new hope in the fight against incurable diseases. A commonly used strategy in the development of messenger RNA (mRNA) medicine is based on the destruction of disease-causing mRNA. Achieving the.....»»
Drugmakers can keep making off-brand weight-loss drugs as FDA backpedals
FDA is reviewing its decision to remove tirzepatide drugs from the shortage list. Facing a lawsuit, the Food and Drug Administration has decided to reconsider its decision to take.....»»
Scientists discover chemical probes for previously "undruggable" cancer target
Hormone-driven cancers, like those of the breast and prostate, often rely on a tricky-to-target protein called Forkhead box protein 1 (FOXA1). FOXA1 mutations can enable these types of cancers to grow and proliferate. Today, FOXA1 is notoriously diff.....»»
New light-induced material shows powerful potential for quantum applications
A class of material called perovskites, which have special electronic bonding with many applications, could be useful for quantum sensing......»»
Glowing proteins enable real-time, 3-D study of essential enzymes
Working in organoid models, researchers at University of California San Diego School of Medicine have developed a new tool to study protein-kinase C (PKC) enzymes, which play a critical role in cell growth, differentiation and survival. Malfunction o.....»»
Calcium transport protein in bacteria offers insights for drug development and food safety
Researchers at Umeå University have revealed details on how bacteria use calcium to regulate vital processes in a way that differs from human cells. This breakthrough is significant in the fight against antibiotic resistance and for increasing safet.....»»