RNA modification: Mechanisms and therapeutic targets
RNA modifications are dynamic and reversible chemical modifications on substrate RNA that regulate mRNA stability, translation, and localization. This review is designed by Dr. Junhong Han and written by his postdoctoral researcher Dr. Lei Qiu and P.....»»
Black holes are firing beams of particles, changing targets over time
Black holes seem to provide endless fascination to astronomers. This is at least partly due to the extreme physics that takes place in and around them, but sometimes, it might harken back to cultural touchpoints that made them interested in astronomy.....»»
Setting minimum targets for wildlife conservation excludes restoration and ecosystem management, researcher argues
Although the grizzly is featured prominently on the California state flag, the golden bear has been extinct in the wild since the 1920s......»»
Epigenetic insights: How hybrid poplar regenerates shoots
Understanding plant regeneration at the molecular level is pivotal for advancements in genetic transformation and genome editing. Previous studies have underscored the importance of DNA methylation in model organisms, yet the specific mechanisms in w.....»»
Desert poplar"s genetic blueprint: Insights into adaptation and survival mechanisms
Populus pruinosa is a relic species surviving in the harsh desert environments of western China and Central Asia. As global warming and desertification intensify, understanding the genetic mechanisms behind its ecological adaptation is crucial. Previ.....»»
Ambitious targets are needed to end ocean plastic pollution by 2100, analysis finds
A collaboration between researchers at Imperial College London and GNS Science, suggests that reducing plastic pollution by 5% per year would stabilize the level of microplastics—plastics less than 5 mm in length—in the surface oceans......»»
Unveiling a novel AAK1 inhibitor: How chemical proteomics unlock therapeutic potential
Enhancing drug development for life-threatening diseases like cancer hinges on a deep understanding of protein kinases, making it a focal point for researchers. These enzymes, encoded by more than 500 human genes, serve as critical players in cellula.....»»
Scientists report on a new approach for deducing proton radii from charge-changing reactions
A study systematically measured the charge-changing reaction cross section of 24 light nuclei on carbon and hydrogen targets at the GSI Helmholtz Centre for Heavy Ion Research in Germany......»»
Researchers reveal dynamic structure of FLVCR proteins and their function in nutrient transport
It is known that malfunctions of the proteins FLVCR1 and FLVCR2 lead to rare hereditary diseases in humans that cause motor, sensory and neurological disorders. However, the biochemical mechanisms behind this and the physiological functions of the FL.....»»
Chevy Silverado EV"s RST First Edition targets retail truck buyers
Chevrolet will promote the Silverado EV RST First Edition's capability and performance as a signature marketing message as it works to attract pickup buyers to the electric version......»»
Researchers track secret Russian missile launchers in Ukraine using public satellite data
In the occupied far east of Ukraine, Russian forces are aiming waves of missiles against Ukrainian civilian targets. Each of Russia's state-of-the-art missile launch systems costs more than US$100 million (A$150 million). They allow Russia to launch.....»»
Astronomers observe jet reorientation in "Death Star" black holes
Huge black holes are firing powerful beams of particles into space—and then changing their aim to fire at new targets. This discovery, made using NASA's Chandra X-ray Observatory and the U.S. National Science Foundation (NSF) National Radio Astrono.....»»
Conservation of "Nature"s Strongholds" needed to halt biodiversity loss, say researchers
To achieve global biodiversity targets, conservationists and governments must prioritize the establishment and effective management of large, interconnected protected areas with high ecological integrity, John G. Robinson from the Wildlife Conservati.....»»
Climate change is a human rights issue
In April, the European Court of Human Rights ruled in favor of a group of seniors who alleged that the Swiss government's failure to meet climate change mitigation targets is having an adverse impact on their health, well-being and quality of life......»»
Researchers identify new drivers of antibiotic resistance in bacteria
Two newly discovered mechanisms in bacteria have been identified that can contribute to the development of antibiotic resistance. Changing the number of copies of resistance genes in bacteria increases antibiotic resistance, and can do so very quickl.....»»
Transformation and mechanisms of climate wet/dry change on the northern Tibetan Plateau under global warming
Historical patterns of climate change can provide ways to predict future climate change. During geological history, the earth has experienced many warm periods of different time scales, such as the mid-Holocene warm period, the medieval climate anoma.....»»
Tesla must face fraud suit for claiming its cars could fully drive themselves
Lawsuit targets 2016 claim that all Tesla cars "have full self-driving hardware." Enlarge (credit: Getty Images | SOPA Images) A federal judge ruled yesterday that Tesla must face a lawsuit alleging that it committed fra.....»»
Research identifies mechanism behind drug resistance in malaria parasite
Collaborating researchers have discovered a link between malaria parasites' ability to develop resistance to antimalarial drugs—specifically artemisinin (ART)—through a cellular process called transfer ribonucleic acid (tRNA) modification. tRNA m.....»»
Heating proteins to body temperature reveals new drug targets
Some proteins shift their shape when exposed to different temperatures, revealing previously unknown binding sites for medications, new research has found......»»
MITRE EMB3D improves security for embedded devices
MITRE released EMB3D, a cybersecurity threat model for embedded devices. The model provides a cultivated knowledge base of cyber threats to embedded devices, providing a common understanding of these threats with the security mechanisms required to m.....»»
Chemical tweaks to a toad hallucinogen turns it into a potential drug
Targets a different serotonin receptor from other popular hallucinogens. Enlarge / The Colorado River toad, also known as the Sonoran Desert Toad. (credit: Mark Newman) It is becoming increasingly accepted that classic p.....»»