Realizing precision medicine through pathogen genome sequencing
Those familiar with the medical industry have undoubtedly heard the term "precision medicine" with great frequency. As a matter of fact, the development of genome sequencing technology in recent years has advanced the treatment of infections from unk.....»»
Drug delivery system overcomes circulatory roadblock that prevents gene therapies from reaching their targets
Exploiting the remarkable capability of viruses to transport gene therapies past what until now has been a circulatory roadblock is at the heart of a University of Alberta-led discovery that promises to re-energize the field of genetic medicine......»»
De-extinction company provides a progress report on thylacine efforts
Stem cell editing, complete genome, and cane toad resistance mark necessary steps. Colossal, the company founded to try to restore the mammoth to the Arctic tundra, has also deci.....»»
Structural biology analysis of a Pseudomonas bacterial virus reveals a genome ejection motor
The viruses that infect bacteria are the most abundant biological entities on the planet. For example, a recent simple study of 92 showerheads and 36 toothbrushes from American bathrooms found more than 600 types of bacterial viruses, commonly called.....»»
Scientists uncover how transcription drives motion within the genome
A team of scientists has discovered surprising connections among gene activity, genome packing, and genome-wide motions, revealing aspects of the genome's organization that directly affect gene regulation and expression......»»
Turtle genome provides new clues on the evolution of vertebrates
Scientists from the UAB and Iowa State University have generated the genome assemblies of two hidden-neck turtles. The results, which revealed a new three-dimensional structure of the genome within the phylogenetic group of reptiles, birds and mammal.....»»
Chemical trick activates antibiotic directly at the pathogen
Colistin is a last-resort antibiotic that is usually only used for severe infections with resistant bacteria. This is due to its severe kidney-damaging side effects, which occur in about 30% of treated patients. A research team at the Helmholtz Cente.....»»
New genome reconstruction advances thylacine de-extinction efforts
New scientific milestones in the mission to reverse the extinction of the thylacine (Tasmanian tiger) are advancing University of Melbourne research and progressing potential solutions to the broader extinction crisis......»»
Environmental DNA and epidemics in wood frogs: Collaboration examines eDNA"s precision in population size estimation
Tracy Rittenhouse, associate professor of natural resources and the environment in UConn's College of Agriculture, Health and Natural Resources (CAHNR), was doing an experiment to study ranavirus epidemics in wood frogs. When Meghan Parsley, then a P.....»»
New technique enhances precision in measuring short-lived atomic nuclei
Researchers at the Heavy Ion Research Facility in Lanzhou (HIRFL-CSR) have introduced a technique, Tune-IMS, designed to improve the precision of isochronous mass spectrometry (IMS) in measuring short-lived atomic nuclei. The development offers refin.....»»
Hybrid quantum error correction technique integrates continuous and discrete variables
A major challenge in realizing quantum computers is the development of quantum error correction technology. This technology offers a solution for addressing errors that occur in the qubit, the basic unit of quantum computation, and prevents them from.....»»
Genome sequencing could unlock answers to yellow jacket behavior
The most recognizable yellow jacket at Georgia Tech is made of fabric and foam, but Professor Mike Goodisman and a team of researchers revealed a far more complex cellular structure by successfully sequencing the genome of two local species of yellow.....»»
First mRNA stabilizing substance could aid in development of innovative mRNA therapeutics
Messenger RNA–based therapeutics and vaccines are the new hope in the fight against incurable diseases. A commonly used strategy in the development of messenger RNA (mRNA) medicine is based on the destruction of disease-causing mRNA. Achieving the.....»»
A unified theory for predicting pathogen competition: Exploring how emerging new strains replace previous ones
The COVID-19 pandemic showed that predicting the invasion of a novel pathogen into the human population and its evolutionary potential to generate new variants is crucial for preventing future outbreaks. New research conducted at Princeton University.....»»
Scientists discover "selfish DNA" crucial for early human development
A critical transition in early human development is regulated not by our own genes, but by DNA elements called transposons that can move around the genome, Sinai Health researchers have found......»»
Traces of ancient immigration patterns to Japan found in 2,000-year-old genome
A joint research group led by Jonghyun Kim and Jun Ohashi of the University of Tokyo has demonstrated that the majority of immigration to the Japanese Archipelago in the Yayoi and Kofun periods (between 3000 BCE and 538 CE) came from the Korean Penin.....»»
Glowing proteins enable real-time, 3-D study of essential enzymes
Working in organoid models, researchers at University of California San Diego School of Medicine have developed a new tool to study protein-kinase C (PKC) enzymes, which play a critical role in cell growth, differentiation and survival. Malfunction o.....»»
Expansion in situ genome sequencing innovation makes hidden DNA-protein interactions visible
Harvard scientists have unveiled a new technique called expansion in situ genome sequencing (ExIGS) that combines existing in situ genome sequencing (IGS) with expansion microscopy (ExM). The innovation allowed researchers to link nucleus abnormaliti.....»»
Scientists develop a new method to study gene function in cells and tissue
The Gaublomme lab has developed a new optical pooled screening approach called CRISPRmap, which enables the coupling of optical properties of single cells to targeted genetic perturbations. Optical phenotypes are typically inaccessible for sequencing.....»»
Novel protocols for estimating Hamiltonian parameters of a superconducting quantum processor could improve precision
Researchers at Freie Universität Berlin, University of Maryland and NIST, Google AI, and Abu Dhabi set out to robustly estimate the free Hamiltonian parameters of bosonic excitations in a superconducting quantum simulator. The protocols they develop.....»»
AI empowers iNaturalist to map California plants with unprecedented precision
Utilizing advanced artificial intelligence and citizen science data from the iNaturalist app, researchers at the University of California, Berkeley, have developed some of the most detailed maps yet showcasing the distribution of California plant spe.....»»