Chemical trick activates antibiotic directly at the pathogen
Colistin is a last-resort antibiotic that is usually only used for severe infections with resistant bacteria. This is due to its severe kidney-damaging side effects, which occur in about 30% of treated patients. A research team at the Helmholtz Cente.....»»
Chemical trick activates antibiotic directly at the pathogen
Colistin is a last-resort antibiotic that is usually only used for severe infections with resistant bacteria. This is due to its severe kidney-damaging side effects, which occur in about 30% of treated patients. A research team at the Helmholtz Cente.....»»
The Physics Trick That Makes These New Super Cars So Insanely Fast
Zero to 60 in 1.4 seconds? By lowering air pressure under the car, automakers can dial the acceleration way up......»»
Team develops promising new form of antibiotic that makes bacterial cells self-destruct
To address the global threat of antibiotic resistance, scientists are on the hunt for new ways to sneak past a bacterial cell's defense system. Taking what they learned from a previous study on cancer, researchers from the University of Toronto (U of.....»»
Key role of structural defects in amorphous solid deformation uncovered
Researchers at the Indian Institute of Science Education and Research (IISER) Pune and the CSIR-National Chemical Laboratory (NCL) Pune have shown that the macroscopic deformation of amorphous solids is controlled by structural defects within the mat.....»»
Discovery of key protein for biosynthesis of plant defense steroids could enhance pest control strategies
Researchers at the Max Planck Institute for Chemical Ecology have identified GAME15 as a key protein that regulates the biosynthesis of both steroidal glycoalkaloids and steroidal saponins in plants of the genus Solanum......»»
Plant fungus provides new drug target for colorectal cancer therapy
Novel chemical compounds from a fungus could provide new perspectives for treating colorectal cancer, one of the most common and deadliest cancers worldwide......»»
Protein signaling pathway provides insights into cell migration and cancer metastasis
The innate immune response is the body's first line of defense against infection, and a successful immune defense takes a village: a combination of physical barriers, chemical attacks, and an army of specialized white blood cells. But maintaining and.....»»
GPT-4-based AI agents show promise for detecting antimicrobial resistance
Researchers at the University of Zurich (UZH) have used artificial intelligence (AI) to help identify antibiotic-resistant bacteria. The team led by Adrian Egli, UZH professor at the Institute of Medical Microbiology, is the first to investigate how.....»»
Microbiome studies in humans and zoo animals pave the way for new drug development
Microorganisms do not just colonize the body of mammals during infections. Billions of microbes can be found on and in healthy humans and animals at any given time, communicating with each other via chemical signals and thus influencing their health......»»
Plate tectonics drive compositional evolution of the upper mantle, study finds
On present-day Earth, plate subduction continuously modifies the chemical composition of the convecting mantle, and various mantle sources linked to these processes have been widely studied. However, when did global chemical heterogeneity of the conv.....»»
mRNA vaccines for disease outbreaks can be synthesized in less time with new technique
In an era where viral outbreaks can escalate into global pandemics with alarming speed, the ability to quickly develop new vaccines has become crucial. However, the speed of vaccine production is limited because the mRNA used in it is partly chemical.....»»
Biological control generates "desirable outcomes" within all One Health dimensions, research reveals
New CABI-led research has revealed that biological control generates "desirable outcomes" within all One Health dimensions—mitigating global change issues such as chemical pollution, biocide resistance, biodiversity loss, and habitat destruction......»»
Scientists discover chemical probes for previously "undruggable" cancer target
Hormone-driven cancers, like those of the breast and prostate, often rely on a tricky-to-target protein called Forkhead box protein 1 (FOXA1). FOXA1 mutations can enable these types of cancers to grow and proliferate. Today, FOXA1 is notoriously diff.....»»
A unified theory for predicting pathogen competition: Exploring how emerging new strains replace previous ones
The COVID-19 pandemic showed that predicting the invasion of a novel pathogen into the human population and its evolutionary potential to generate new variants is crucial for preventing future outbreaks. New research conducted at Princeton University.....»»
How profits from big pharma"s use of genetic information could revolutionize nature conservation
The blue blood of threatened horseshoe crabs contains a chemical essential for testing the safety of vaccines. So these ancient creatures are highly sought after by pharmaceutical companies worldwide, contributing to declines in their populations......»»
Digital quantum simulation of nuclear magnetic resonance experiments
Programmable quantum computers have the potential to efficiently simulate increasingly complex molecular structures, electronic structures, chemical reactions, and quantum mechanical states in chemistry that classical computers cannot. As the molecul.....»»
Calcium transport protein in bacteria offers insights for drug development and food safety
Researchers at Umeå University have revealed details on how bacteria use calcium to regulate vital processes in a way that differs from human cells. This breakthrough is significant in the fight against antibiotic resistance and for increasing safet.....»»
How did the building blocks of life arrive on Earth? Zinc fingerprints in meteorites offer clues
Researchers have used the chemical fingerprints of zinc contained in meteorites to determine the origin of volatile elements on Earth. The results suggest that without 'unmelted' asteroids, there may not have been enough of these compounds on Earth f.....»»
Study unveils cobalt(III) reaction mechanism with nitriles, opening pathways for drug development
A research team led by Professor Jaeheung Cho from the Department of Chemistry at UNIST has published a study in the Journal of the American Chemical Society reporting the reaction mechanism of cobalt(III)-based metal complexes with nitrile substance.....»»
Targeting "selfish" bacteria could optimize inhibitors that fight antibiotic resistance
As strains of pathogens resistant to frontline antibiotics become more common worldwide, clinicians are more often turning to combination treatments that degrade this resistance as a first treatment option......»»