Molecular mechanism of ZDHHC18-mediated palmitoylation of cGAS in innate immunity inhibition
Cyclic GMP-AMP synthase (cGAS), a double-stranded DNA (dsDNA) sensing protein, plays an important role in the strong innate immune response induced by pathogen derived nucleic acids......»»
JWST sets a new record, sees newly forming stars in the Triangulum galaxy
Our Milky Way bristles with giant molecular clouds birthing stars. Based on what we see here, astronomers assume that the process of star creation also goes on similarly in other galaxies. It makes sense since their stars have to form somehow. Now, t.....»»
Artificial design and biosynthesis of a single-domain catenated dihydrofolate reductase
This study was led by Prof. Wen-Bin Zhang (College of Chemistry and Molecular Engineering, Peking University & Beijing Academy of Artificial Intelligence) and Dr. Jing Fang (College of Chemistry and Molecular Engineering, Peking University). A single.....»»
Novel molecular ionization dissociation pathway induced by Interatomic Coulombic Decay
A research group led by Prof. Ma Xinwen at the Institute of Modern Physics (IMP) of the Chinese Academy of Sciences (CAS) has observed a novel molecular ionization dissociation pathway triggered by Interatomic Coulombic Decay (ICD). The study, publis.....»»
Development of tissue molecular imaging technique using multiple probes at hundreds of microns
Researchers have shown it is possible to image small animal tissue clearly to several hundred micrometers using multi-probe imaging, reports a recent study in Scientific Reports......»»
Battling persistence in tuberculosis bacteria
Researchers at the Indian Institute of Science (IISc), in collaboration with NCBS and InStem, have uncovered an important mechanism that allows the tuberculosis (TB) bacterium to persist in the human host for decades. They found that a single gene in.....»»
GPCR structure: Research reveals molecular origins of function for a key drug target
Through an international collaboration, scientists at St. Jude Children's Research Hospital have leveraged data science, pharmacology and structural information to conduct an atomic-level investigation into how each amino acid in the receptor that bi.....»»
An advanced computational tool for understanding quantum materials
Researchers at the University of Chicago's Pritzker School of Molecular Engineering (PME), Argonne National Laboratory, and the University of Modena and Reggio Emilia have developed a new computational tool to describe how the atoms within quantum ma.....»»
Location, location, location: Research reveals the hidden power of intracellular neighborhoods
New findings published in Molecular Cell provide details about the hidden organization of the cytoplasm—the soup of liquid, organelles, proteins, and other molecules inside a cell. The research shows it makes a big difference where in that cellular.....»»
Using molecular "cookie cutters" to view membrane protein organization
The membrane that encases a biological cell is not simply a barrier; it is chock full of proteins involved in all sorts of critical biological functions. To really understand what membrane proteins are doing and how, researchers need to know how they.....»»
Unveiling the role of autophagy in metabolism and growth for tomato fruit development
Autophagy, a eukaryotic mechanism for breaking down cellular components, is a vital process in lytic organelles such as vacuoles in yeast and plants, and lysosomes in animals. Research has predominantly focused on the model plant Arabidopsis, reveali.....»»
Why paint does not dry slower in a humid environment
A team of physicists at The University of Edinburgh working with an infection and immunity specialist with the university's Roslin Institute has, via experimentation, validated a theory to explain why paint dries at the same rate regardless of humidi.....»»
"Molecular jackhammers" can rupture melanoma cells" membrane, study shows
The Beach Boys' iconic hit single "Good Vibrations" takes on a whole new layer of meaning thanks to a recent discovery by Rice University scientists and collaborators, who have uncovered a way to destroy cancer cells by using the ability of some mole.....»»
Viral enhancement of nanomaterial cancer sensor improves early detection
Researchers from SUTD have developed an advanced system of breast cancer cell detection with improved speed and sensitivity, using a viral mechanism to enhance the tool's sensing accuracy......»»
Research argues that Occam"s razor is an "essential factor that distinguishes science from superstition"
Occam's razor—the principle that when faced with competing explanations, we should choose the simplest that fits the facts—is not just a tool of science. Occam's razor is science, insists a renowned molecular geneticist from the University of Sur.....»»
Researchers use vapor deposition to make covalent organic framework films
Rice University materials scientists developed a fast, low-cost, scalable method to make covalent organic frameworks (COFs), a class of crystalline polymers whose tunable molecular structure, large surface area and porosity could be useful in energy.....»»
Scientists reveal the molecular structure of a complex bacteriophage
The word "virus" is often associated with negative connotations. However, it is important to note that not all viruses are harmful. In fact, there are many viruses that live inside our bodies and play important roles in our health. One example is bac.....»»
Computational scientists generate molecular datasets at extreme scale
A team of computational scientists at the Department of Energy's Oak Ridge National Laboratory has generated and released datasets of unprecedented scale that provide the ultraviolet visible spectral properties of over 10 million organic molecules. U.....»»
New method tags cells with location coordinates for single-cell studies
When a scientist wants to study individual cells at the molecular level within an organ like the heart or brain, they usually break the tissue up to analyze the cells. This provides rich detail about gene activity, but doesn't retain information abou.....»»
Drug-resistant fungus is on the rise worldwide, says molecular biologist
The Candida auris fungus is spreading across the globe at an "alarming" speed. This species of fungus, which can cause fatal infections in risk groups and was first discovered only 10 years ago, can now be found all over the world. In nearly all case.....»»
Scientists identify biosynthetic pathway of chemotherapeutic derived from yew trees
Researchers from the Max Planck Institute of Molecular Plant Physiology have unraveled the biosynthetic pathway of paclitaxel in yew plants, a chemotherapeutic for cancer treatment. This discovery might facilitate the production of this very complex.....»»