Molecular mechanism of ZDHHC18-mediated palmitoylation of cGAS in innate immunity inhibition
Cyclic GMP-AMP synthase (cGAS), a double-stranded DNA (dsDNA) sensing protein, plays an important role in the strong innate immune response induced by pathogen derived nucleic acids......»»
New toolkit makes molecular dynamics simulations more accessible
Molecular dynamics (MD) simulations have become a powerful tool in the ever-growing fields of molecular biology and drug development. While many MD simulation techniques exist, parallel cascade selection MD (PaCS-MD) is a particularly useful one when.....»»
Uncovering key players in gene silencing: Insights into plant growth and human diseases
Monash University biologists have shed light on the intricate molecular mechanisms that are responsible for gene silencing induced by expanded repeats in an international study published today in Nature Plants......»»
Cost-effective nanorod electrodes for molecular hydrogen production
SUNY Polytechnic Institute (SUNY Poly) Associate Professor of Electrical and Computer Engineering Technology Dr. Iulian Gherasoiu and peers have published research in the Journal of Applied Electrochemistry titled "MoVN-coated MoNi4-MoO2 nanorods as.....»»
Key protein regulates immune response to viruses in mammal cells
Researchers have revealed the regulatory mechanism of a specific protein that plays a key role in balancing the immune response triggered by viral infections in mammal cells. These findings could help drive the development of antiviral therapies and.....»»
Effects of organic matter input and temperature change on soil aggregate-associated respiration and microbial carbon use
The Qinghai-Tibet Plateau is one of the most dramatically affected regions by global warming. For a long time, the region has been exposed by low temperature and soil moisture, which led to the severe inhibition of the soil biological activities and.....»»
New model finds previous cell division calculations ignore drivers at the molecular scale
When a single bacterial cell divides into two during periods of rapid growth, it doesn't split in half once it reaches a predetermined size. Instead, data has shown, a cell will divide once it has added a certain amount of mass......»»
Studying spaceflight atrophy with machine learning
Even intense exercise by astronauts cannot compensate for muscle atrophy caused by microgravity. Atrophy occurs, in part, by way of an underlying mechanism that regulates calcium uptake. Recent research has shown exposure to spaceflight alters the up.....»»
Researchers uncover human DNA repair by nuclear metamorphosis
Researchers at the University of Toronto have discovered a DNA repair mechanism that advances understanding of how human cells stay healthy, and which could lead to new treatments for cancer and premature aging......»»
New time-resolved ultraviolet photodissociation mass spectrometry strategy for target protein stability analysis
How mutations impact protein stability and structure dynamics is crucial for understanding the molecular mechanism of the disease and the targeted drug design. However, probing the molecular details of mutation-induced subtle structure dynamics is st.....»»
Why do some people always get lost?
Experience may matter more than innate ability when it comes to sense of direction. Enlarge / Scientists are homing in on how navigation skills develop. (credit: Knowable Magazine (CC BY-ND)) Like many of the researchers.....»»
Decoding the language of cells: Profiling the proteins behind cellular organelle communication
In cellular biology, unraveling the complexities of cellular function at the molecular level remains a paramount endeavor. Significant scientific focus has been placed on understanding the interactions at organelle contact sites, especially between m.....»»
A molecular moon lander: Insight into molecular motion on surfaces at the nanoscale
For years, scientists have been intrigued by how molecules move across surfaces. The process is critical to numerous applications, including catalysis and the manufacturing of nanoscale devices......»»
Discovery of the first fractal molecule in nature
An international team of researchers led by groups from the Max Planck Institute in Marburg and the Philipps University in Marburg has stumbled upon the first regular molecular fractal in nature. They discovered a microbial enzyme—citrate synthase.....»»
Keys to the genome: Unlocking the package with "pioneer transcription factors"
Scientists at the Montreal Clinical Research Institute have discovered the molecular mechanisms responsible for opening up the human genome and expressing new genes......»»
Ocean currents threaten to collapse Antarctic ice shelves, study finds
A new study published in Nature Communications has revealed that the interplay between meandering ocean currents and the ocean floor induces upwelling velocity, transporting warm water to shallower depths. This mechanism contributes substantially to.....»»
New molecular device unlocks potential for targeted drug delivery and self-healing materials
In a new breakthrough that could revolutionize medical and material engineering, scientists have developed a first-of-its-kind molecular device that controls the release of multiple small molecules using force......»»
Researchers develop mechanism of electrical 180° switching of Néel vector in spin-splitting antiferromagnet
A research team led by The Hong Kong University of Science and Technology (HKUST) and Tsinghua University has theoretically proposed a new mechanism of electrical 180° switching of Néel vector and experimentally realized it in antiferromagnetic mat.....»»
Scientists discover new phage resistance mechanism in phage-bacterial arms race
One of the most abundant and deadliest organisms on Earth is a virus called a bacteriophage (phage). These predators have lethal precision against their targets—not humans, but bacteria. Different phages have evolved to target different bacteria an.....»»
Scientists report that buffer and pH strongly affect the phase separation of SARS-CoV-2 N protein
In a new paper published in Molecular Biology of the Cell, the Allain lab (IBC) reported that the phase separation of the SARS-CoV-2 N protein strongly depends on the chosen buffer and pH. For example, the protonation of a single histidine side chain.....»»
First-of-its-kind integrated dataset enables genes-to-ecosystems research
A team of Department of Energy scientists led by Oak Ridge National Laboratory has released the first-ever dataset bridging molecular information about the poplar tree microbiome to ecosystem-level processes. The project aims to inform research regar.....»»