Glycerol phosphate serves as a terminator of glycan elongation in cancer malignancy
Dystroglycans on epithelial cell surfaces interact with the extracellular matrix via long sugar chains (called matriglycans), and they are responsible for cell adhesion. Abnormalities in the formation of matriglycans can impair cell adhesion and caus.....»»
New weight-loss and diabetes drugs linked to lower risk of 10 cancers
For diabetes patients, GLP-1 drugs linked to lower cancer risks compared to insulin. Enlarge / Ozempic is a GLP-1 drug for adults with type 2 diabetes. (credit: Getty | Steve Christo) For patients with Type 2 diabetes, t.....»»
Scientists sustainably create peptide-based medicines, pave way for greener cancer treatments
Scientists from the University of Manchester have uncovered a more efficient and sustainable way to make peptide-based medicines, showing promising effectiveness in combating cancers......»»
Scientists discover new way to control blood vessel growth with the peptide Apelin
Scientists from La Trobe University and Phillipps-University of Marburg (Germany) have discovered how a peptide called Apelin regulates blood vessel growth, opening new avenues of research for cancer treatment, organ regeneration, and tissue engineer.....»»
A combination of multicore magnetic nanoparticles and chemotherapy drugs achieves greater efficacy against cancer cells
The path to a cure for cancer is not unique, as the disease is an extremely complex process. Multiple factors are involved in the process of effectively eliminating a tumor and therefore, being able to have different strategies against cancer is key.....»»
Exploring the molecular basis of how pradimicin A binds to viral N-glycan, a potential SARS-CoV-2 entry inhibitor
HIV, Ebola and most recently, COVID-19 viruses have had an enormous impact on our societies world-wide. All these viruses are "enveloped viruses," viruses that have an exterior envelope that surrounds them largely composed of their host's cells. This.....»»
New method advances cancer detection by counting tiny blood-circulating particles
A University of Houston researcher is reporting a new method to detect cancer which could make cancer detection as simple as taking a blood test. With a 98.7% accuracy rate, the method—which combines PANORAMA imaging with fluorescent imaging—has.....»»
"Extraordinary" 4,000-year-old Egyptian skull may show signs of attempts to treat cancer
From ancient texts we know that—for their times—the ancient Egyptians were exceptionally skilled at medicine. For example, they could identify, describe, and treat diseases and traumatic injuries, build protheses, and put in dental fillings. Othe.....»»
New approach uses "cloaked" proteins to deliver cancer-killing therapeutics into cells
An interdisciplinary collaboration has designed a way to "cloak" proteins so that they can be captured by lipid nanoparticles, which are akin to tiny bubbles of fat. These bubbles are small enough to sneak their hidden cargo into living cells, where.....»»
Bacterial model helps reveal how our bodies prevent population explosions—and cancer
For the size of any population to remain stable over time, its birth and death rates must be balanced. If the birthrate is too high, there could be a population explosion; if it is too low, the population will shrink. This kind of balance exists, for.....»»
‘I"m an Oncologist and This Is the Vegetable I Swear by for Cancer Prevention’
‘I"m an Oncologist and This Is the Vegetable I Swear by for Cancer Prevention’.....»»
Common heartburn medications may help fight cancer and other immune disorders in dogs, researchers find
Researchers at the Texas A&M School of Veterinary Medicine and Biomedical Sciences (VMBS) have discovered that proton pump inhibitors (PPIs)—medications commonly used to treat heartburn and acid reflux in people and animals—may be effective at fi.....»»
Unveiling a novel AAK1 inhibitor: How chemical proteomics unlock therapeutic potential
Enhancing drug development for life-threatening diseases like cancer hinges on a deep understanding of protein kinases, making it a focal point for researchers. These enzymes, encoded by more than 500 human genes, serve as critical players in cellula.....»»
Study finds mitochondrial phosphate carrier plays an important role in virulence of Candida albicans
In a paper published in Mycology, Professor Yan Wang's team found that in both nematode and murine infection models, the lack of MIR1 gene, which encodes mitochondrial phosphate carrier, can lead to severe virulence defects in Candida albicans......»»
How yeasts manage to compensate for the genetic imbalance of extra chromosomes
Having extra chromosomes is typically an issue for an organism and can disrupt development or cause disease. But some cells benefit instead. For example, cancer cells or pathogenic yeasts can use extra chromosomes to escape treatment and become drug-.....»»
Designing a tiny new tool to map and treat children"s brain cancer
Medulloblastoma is the most common cancerous brain tumor in children, and fighting it requires an approach that is delicate, durable, and direct. Now a group of researchers at UQ's Australian Institute for Bioengineering and Nanotechnology (AIBN) bel.....»»
Study reveals promising development in cancer-fighting nanotechnologies
A new study conducted by the Wilhelm Lab at the University of Oklahoma examines a promising development in biomedical nanoengineering. Published in Advanced Materials, the study explores new findings on the transportation of cancer nanomedicines into.....»»
Using hybrid nanotubes to enhance cancer treatment with intracellular protein delivery
The intracellular delivery of proteins is an important technique for unveiling the cellular functions, protein complex structure, and therapeutics. However, conventional delivery methods have several limitations......»»
Cancer drug pollution is a growing global concern
As incidence of cancer increases globally, the use of cancer drugs is also growing at a rate of approximately 10 percent per year in developed countries......»»
Scientists develop new geochemical "fingerprint" to trace contaminants in fertilizer
An international team of scientists has uncovered toxic metals in mineral phosphate fertilizers worldwide by using a new tool to identify the spread and impact of such contaminants on soil, water resources, and food supply......»»
Stiffness and viscosity of cells found to differ in cancer and other diseases
During illness, the stiffness or viscosity of cells can change. Tom Evers demonstrated this by measuring such properties of human immune cells for the first time. "The stiffness of certain cells could be a way to make a diagnosis," Evers said......»»