Glucagon receptor structures uncover new arrestin interaction mechanism
G protein-coupled receptors (GPCRs) are essential for cell signal transduction and constitute the largest drug target protein family. Upon agonist stimulation, these receptors activate multiple downstream transducers, including G proteins and arresti.....»»
Scientists reveal transport mechanism of norepinephrine transporter and binding mode of small molecule and peptide drugs
Noradrenaline (NA) is an important monoamine neurotransmitter in the nervous system. The noradrenaline transporter (NET) located on the presynaptic membrane can transport NA into presynaptic neurons......»»
Researchers elucidate mechanisms behind protein selectivity in adenosine receptor
In a new study, a multinational research team led by Dr. Adnan Sljoka (RIKEN) and Prof. Akio Kitao (Tokyo Tech), in collaboration with Prof. Scott Prosser (University of Toronto), has carried out experimental and computational studies to elucidate th.....»»
Economists uncover hidden influence of top campaign donors
The death of a top donor during an electoral cycle decreases the likelihood that a candidate will be elected by more than three percentage points, according to an innovative new study by Cornell economists and colleagues......»»
When it comes to DNA replication, humans and baker"s yeast are more alike than different, scientists discover
Humans and baker's yeast have more in common than meets the eye, including an important mechanism that helps ensure DNA is copied correctly, reports a pair of studies published in the journals Science and Proceedings of the National Academy of Scienc.....»»
Researchers uncover 500 million-year-old mollusk ancestor
A team of researchers including scientists from the University of Oxford have made an astonishing discovery of a new species of mollusk that lived 500 million years ago. The new fossil, called Shishania aculeata, reveals that the most primitive mollu.....»»
Sustainable and reversible 3D printing method uses minimal ingredients and steps
A new 3D printing method developed by engineers at the University of California San Diego is so simple that it uses a polymer ink and salt water solution to create solid structures. The work, published in Nature Communications, has the potential to m.....»»
A nose for earthy notes: Human odorant receptor for geosmin identified for the first time
Geosmin is a volatile compound of microbial origin with a distinct "earthy" to "musty" odor that can affect the quality of water and food. It is responsible for the typical odor that occurs when rain falls on dry soil. This odorant is produced by mic.....»»
Study reveals impact of concern about misinformation on Americans" media consumption habits
Most Americans are aware of fake news and misinformation. In a new study, researchers from the University of Pennsylvania sought to uncover whether the threat of misinformation drives Americans to seek out news sources that reflect their own politica.....»»
Stem cell harmony: How solanaceae plants maintain homeostasis through receptor compensation
A pivotal study sheds light on the evolutionary conservation of stem cell homeostasis in Solanaceae, revealing how receptor compensation mechanisms ensure the continuous and orderly formation of plant organs. This research uncovers the genetic interp.....»»
Elusive predicted water structure created in the laboratory
Clathrate hydrates are complex water structures that contain foreign guest molecules inside a host water-molecule shell. A predicted clathrate hydrate phase structure has been stably synthesized in the lab and may play an important role in future mat.....»»
Scientists identify the predictability limit of oceanic mesoscale eddy tracks in the South China Sea
Oceanic mesoscale eddies (OMEs) are swirling water structures that play a crucial role in ocean dynamics. These eddies transport heat, salt, nutrients, and other materials across the ocean, significantly influencing marine ecosystems and global clima.....»»
Highways to health: Bicontinuous structures speed up cell migration
One of the most important but least understood aspects of healing is cell migration, or the process of cells moving from one part of the body to another. "If you are an ambulance out in the woods," says Karen Xu, an M.D/Ph.D. student in Medicine and.....»»
Best OnePlus Open screen protectors to buy in 2024
Keep your OnePlus Open display safe and protected with these screen protectors. The post Best OnePlus Open screen protectors to buy in 2024 appeared first on Phandroid. The OnePlus Open is a foldable smartphone with a book-style mechanism......»»
Q&A: Why wildfires don"t just burn, but can also pollute aquatic ecosystems
Last week, wildfires blazed across western Canada, turning the town of Jasper, located near Alberta's Jasper National Park, into ashes. The local government estimated that the fire damaged or destroyed up to half of the town's structures......»»
Ice 0: Researchers discover a new mechanism for ice formation
Ice is far more complicated than most of us realize, with over 20 different varieties known to science, forming under various combinations of pressure and temperature. The kind we use to chill our drinks is known as ice I, and it's one of the few for.....»»
Physicists uncover key to resolving long-standing inertial confinement fusion hohlraum drive deficit
A team of researchers at Lawrence Livermore National Laboratory (LLNL) has made advancements in understanding and resolving the long-standing "drive-deficit" problem in indirect-drive inertial confinement fusion (ICF) experiments. This discovery coul.....»»
Discovery of Piezo1"s new signaling mechanism may aid search for better pain and itch treatments
The human body's sense of touch is so important it can be found throughout the body, not just on the skin. Two tiny sensors of touch, Piezo1 and Piezo2, signal the lightest pressures and can be found monitoring the circulatory system, telling the bod.....»»
Astrophysicists uncover supermassive black hole/dark matter connection in solving the "final parsec problem"
Researchers have found a link between some of the largest and smallest objects in the cosmos: supermassive black holes and dark matter particles......»»
Scientists uncover fundamental rules for how dengue virus infects its mosquito and human hosts
Mosquito-borne viral infections once confined to tropical regions are spreading. Dengue virus infects up to 400 million people worldwide each year according to World Health Organization estimates, and no available treatments exist for this disease......»»
Researchers zero in on the underlying mechanism that causes alloys to crack when exposed to hydrogen-rich environments
When deciding what material to use for infrastructure projects, metals are often selected for their durability. However, if placed in a hydrogen-rich environment, like water, metals can become brittle and fail. Since the mid-19th century, this phenom.....»»