Glucagon receptor structures uncover new arrestin interaction mechanism
G protein-coupled receptors (GPCRs) are essential for cell signal transduction and constitute the largest drug target protein family. Upon agonist stimulation, these receptors activate multiple downstream transducers, including G proteins and arresti.....»»
Evolution of cooperation in multiplex networks through asymmetry between interaction and replacement
Cooperation is one of the elements that form the foundation of social systems; nonetheless, the intricacies of its evolutionary mechanisms are not fully understood. Recently, "multiplex networks" have garnered attention as a model that represents the.....»»
Researchers report effect of hypoxia on periosteal stem cells
A new study has shown that the interaction of miR-584-5p and RUNX2 could mediate PSC osteogenic differentiation induced by hypoxia. The work is published in the World Journal of Stem Cells......»»
Interacting polarons: Physicists simulate interacting quasiparticles in ultracold quantum gas
An electron moving through a solid generates a polarization in its environment due to its electric charge. In his theoretical considerations, the Russian physicist Lev Landau extended the description of such particles by their interaction with the en.....»»
Google payment to Apple concerned search giant execs – wanted to use EU law to reduce it
A new report says that the growing size of the Google payment to Apple to remain the default search engine on Apple devices concerned senior execs at the search giant – and they wanted to use EU law as a mechanism to reduce it. One legal academi.....»»
A mechanism that controls the genomic structure during early differentiation into neuroectoderm
A group of scientists have discovered that a one of the components of the polycomb-type of transcriptional repressor complex (PRC), Phc1 (Rae28), regulates the chromatin state of cells and plays a critical role in the process of undifferentiated cell.....»»
A new formula to calculate the strength of thin conical structures
Conical structures can have advantageous applications in a variety of fields, ranging from robotics to civil engineering. Studies have found that conical shells made of liquid crystal elastomer films can be effective lifters; devices that can generat.....»»
Scientists uncover cause of mysterious deaths of elephants in Zimbabwe
A bacterium, closely associated with deadly septicemia, could have caused the deaths of six African elephants in Zimbabwe and possibly more in neighboring countries. The findings place infectious diseases on the list of pressures on African elephants.....»»
Researchers propose new strategy to improve efficiency for nanotherapeutic delivery in tumors
A team led by Prof. Wang Yucai and Associate Prof. Jiang Wei from the University of Science and Technology of China (USTC) of the Chinese Academy of Sciences (CAS) revealed the mechanism of the tumor vascular basement membranes (BM) blocking nanopart.....»»
New 3D-printed tumor model enables faster, less expensive and less painful cancer treatment
An international team of interdisciplinary researchers has successfully created a method for better 3D modeling of complex cancers. The University of Waterloo-based team combined cutting-edge bioprinting techniques with synthetic structures or microf.....»»
A strategy for the spin-acoustic control of silicon vacancies in a 4H silicon carbide-based bulk acoustic resonator
Bulk acoustic resonators—stacked material structures inside which acoustic waves resonate—can be used to amplify sounds or filter out undesired noise. These resonators have found wide use in today's RF telecommunication, like Front-End Modules (F.....»»
Researchers uncover DarkGate malware’s Vietnamese connection
WithSecure researchers have tracked attacks using DarkGate malware to an active cluster of cybercriminals operating out of Vietnam. DarkGate is a remote access trojan (RAT) that has been used in attacks since at least 2018 and is currently available.....»»
International team develops novel DNA nano engine
An international team of scientists has recently developed a novel type of nano engine made of DNA. It is driven by a clever mechanism and can perform pulsing movements. The researchers are now planning to fit it with a coupling and install it as a d.....»»
Physical theory improves protein folding prediction
Proteins are important molecules that perform a variety of functions essential to life. To function properly, many proteins must fold into specific structures. However, the way proteins fold into specific structures is still largely unknown. Research.....»»
Hidden information extraction from layered structures through terahertz imaging
Noninvasive inspection of layered structures is challenging for time-resolved imaging methods, where the resolution and contrast can be compromised by prominent signal attenuation with interlayer reflections and dispersions......»»
Uncovering previously unexplored cellular mechanisms
Single-cell and spatially resolved omics have helped scientists take a closer look at tissue composition, structure, and function. This comprehensive understanding paves the way for them to uncover some intricate and previously unknown disease mechan.....»»
Study shows forensic evidence can survive underwater for weeks
Forensic fibers can survive underwater for much longer than previously thought—which could help criminal investigators uncover vital evidence......»»
DNA methylation: The hidden mechanism enabling plants to adapt in a warmer world
As global warming continues to redefine ecosystems, plants are increasingly tasked with swift adaptation to ensure their survival. One primary mechanism facilitating such rapid adaptation is epigenetic memory, specifically DNA methylation......»»
Scientists explain unique formation of ancient algae that evolved photosynthesis and oxygenated the planet
Scientists have for the first time revealed how blue-green algae—visible as the slippery green slime in stagnant water, riverbeds, and seashores—weaves itself into large weblike structures......»»
Interplay of free electrons: Tailored electron pulses for improved electron microscopy
Electron microscopes provide unique vistas of nanoscale structures, but their resolution is limited by the mutual repulsion of electrons. Researchers in Göttingen have now succeeded in precisely measuring the influence of these interactions. They di.....»»
High-performance SERS substrate proposed based on 2H-TaS2 and single-atom-layer gold clusters
Recently, a research team led by Professor Yang Liangbao from Institute of Health and Medical Technology, Hefei Institutes of Physical Science (HFIPS), Chinese Academy of Sciences (CAS) proposed an electromagnetic field enhancement mechanism based on.....»»