Efficiently smuggling drugs into cells
A new, patented method called Progressive Mechanoporation makes it possible to mechanically disrupt the membranes of cells for a short time period and let drugs or genes inside cells. In this way, researchers can test new therapies more easily than b.....»»
Nanopillars create tiny openings in the nucleus without damaging cells
Imagine trying to poke a hole in the yolk of a raw egg without breaking the egg white. It sounds impossible, but researchers at the University of California San Diego have developed a technology that performs a similarly delicate task in living cells.....»»
To build a giant sheep, man spends 10 years smuggling, cloning, and inseminating
He takes his hobbies seriously. Readers of a certain age might remember Dolly, a Finn-Dorset sheep born in 1996 to three mothers and some proud Scottish scientists. Dolly generate.....»»
Research provides new insights into role of mechanical forces in gene expression
The genome inside each of our cells is modeled by tension and torsion—due in part to the activity of proteins that compact, loop, wrap and untwist DNA—but scientists know little about how those forces affect the transcription of genes......»»
Seeing double: Designing drugs that target "twin" cancer proteins
Some proteins in the human body are easy to block with a drug; they have an obvious spot in their structure where a drug can fit, like a key in a lock. But other proteins are more difficult to target, with no clear drug-binding sites......»»
To build a giant sheep, man spends 10 years smuggling, cloning, and inseminating
He takes his hobbies seriously. Enlarge / A male argali sheep in the wild. (credit: Getty Images) Readers of a certain age might remember Dolly, a Finn-Dorset sheep born in 1996 to three mothers and some proud Scottish s.....»»
Fluorescent molecules to illuminate life: Simplified synthesis with formaldehyde
A research team has recently made a breakthrough in synthesizing organic fluorophores more cost-effectively and atom-efficiently than ever before by using formaldehyde, the simplest carbon molecule. Their findings were published in Angewandte Chemie.....»»
New method achieves first-ever imaging of pathogens on lettuce leaves in real-time
As the global population surpasses 8 billion, the challenge of producing sufficient food becomes increasingly pressing. The Netherlands stands as the world's second-largest food exporter, efficiently cultivating a wide variety of crops. However, plan.....»»
Your cells are dying. All the time.
Your cells are dying. All the time......»»
Elucidating the mechanism of cell division during plant self-healing
When the stem of a plant is injured, the surrounding cells proliferate to repair and fuse the damaged tissue, eventually restoring function. This self-healing property is utilized in grafting techniques to propagate fruit and vegetable plants......»»
Scientists identify structural basis of stitched-together protein complexes that recycle most proteins in cells
Scientists at Sanford Burnham Prebys have developed a clearer picture of how crucial machinery in the human cell's recycling process for obsolete and misshapen proteins—known as proteasomes—are formed......»»
Building better bone grafts: Nanofibrous scaffolds to activate two main collagen receptors in bone cells
Each year, about 2.2 million bone-grafting procedures are performed worldwide, the gold standard of care being autografting, which uses the patient's own bone for tooth implantation and to repair and reconstruct parts of the mouth, face and skull......»»
Scientists develop method to control timing of synthetic DNA droplet division
Many cellular functions in the human body are controlled by biological droplets called liquid-liquid phase separation (LLPS) droplets. These droplets, made of soft biological materials, exist inside living cells but are not enclosed by membranes like.....»»
Semimetal-induced covalency achieves high-efficiency electrocatalysis for platinum intermetallic compounds
Compared with other types of batteries, proton exchange membrane fuel cells have the advantages of high discharge power and no pollution, which is also an important carrier for hydrogen energy conversion and utilization. Platinum intermetallic compou.....»»
Sustainable metal-recycling method reduces cost and greenhouse gas emissions
A research team led by Rice University's James Tour has developed a method to recycle valuable metals from electronic waste more efficiently while significantly reducing the environmental impact typically associated with metal recycling......»»
How synchronization supports social interactions: Taking turns during conversations may help coordinate cues
Turn-taking dynamics of social interactions are important for speech and gesture synchronization, enabling conversations to proceed efficiently, according to a study published September 25, 2024, in the open-access journal PLOS ONE by Tifenn Fauviaux.....»»
New insights into hot carrier solar cells: Study explores hot electron tunneling and collection to enhance efficiency
Hot carrier solar cells, a concept introduced several decades ago, have long been seen as a potential breakthrough in solar energy technology. These cells could surpass the Shockley–Queisser efficiency limit, which is a theoretical maximum efficien.....»»
Mechanism behind autophagy trigger unveiled
An international research team led by Osaka University has identified a new mechanism crucial for the initiation of autophagy, a self-degradation process cells use to eliminate unneeded or damaged components. In recent years, autophagy has also been.....»»
Yeast chit-chat: How microorganisms communicate food shortages
To grow and survive, tiny organisms such as yeast must sometimes adapt their nutrient sources in response to changes in the environment. FMI researchers have now found that yeast cells communicate with each other to use less favorable nutrients if th.....»»
Better together: Gut microbiome communities found to have enhanced resilience to drugs
Many human medications can directly inhibit the growth and alter the function of the bacteria that constitute our gut microbiome. EMBL Heidelberg researchers have now discovered that this effect is reduced when bacteria form communities......»»
Compact "gene scissors" enable effective genome editing, may offer future treatment of high cholesterol gene defect
CRISPR-Cas is used broadly in research and medicine to edit, insert, delete or regulate genes in organisms. TnpB is an ancestor of this well-known "gene scissors" but is much smaller and thus easier to transport into cells......»»