Downtime at the nerve cell"s protein factories
Charcot-Marie-Tooth disease (CMT) is a rare hereditary condition. It occurs when genetic changes disrupt the transmission of nerve signals from the brain to the muscles of the extremities, particularly those of the lower limbs. This leads to a gradua.....»»
De-extinction company provides a progress report on thylacine efforts
Stem cell editing, complete genome, and cane toad resistance mark necessary steps. Colossal, the company founded to try to restore the mammoth to the Arctic tundra, has also deci.....»»
Enhancing recombinant protein expression in lettuce
Recombinant proteins are crucial in pharmaceutical and other industries. A production method uses plants as hosts in transient protein expression systems. Researchers at the University of Tsukuba developed a technique to increase recombinant protein.....»»
Creating a simplified form of life: Scientists build modules for a synthetic cell
It is one of the most fundamental questions in science: how can lifeless molecules come together to form a living cell? Bert Poolman, Professor of Biochemistry at the University of Groningen, has been working on this problem for over 20 years. He aim.....»»
How Cells Resist the Pressure of the Deep Sea
Cell membranes from comb jellies reveal a new kind of adaptation to the deep sea: curvy lipids that conform to an ideal shape under pressure......»»
Team achieves successful reproduction of hematopoietic stem cell developmental process in an in vitro culture system
Researchers at Kumamoto University have achieved a notable advancement in stem cell biology by reproducing the developmental process of hematopoietic stem cells (HSCs) in vitro. This culture system not only enhances our understanding of how HSCs deve.....»»
Team develops promising new form of antibiotic that makes bacterial cells self-destruct
To address the global threat of antibiotic resistance, scientists are on the hunt for new ways to sneak past a bacterial cell's defense system. Taking what they learned from a previous study on cancer, researchers from the University of Toronto (U of.....»»
Focus on making the sure bets so you can win today
Those bets include the most profitable (and increasingly efficient) gasoline-powered vehicles, proven battery-cell chemistries for electric vehicles and the driver-assist technology that more than 90 percent of new vehicles already have......»»
Single-molecule imaging reveals aberrant DNA-binding dynamics of cancer-linked chromatin remodelers
Biophysical chemists from the National University of Singapore (NUS) have uncovered a previously hidden landscape that governs the intracellular organization and dynamics of SWI/SNF chromatin remodelers, an important class of protein complexes that c.....»»
Researchers find new role for protein in combating age-related diseases
McMaster University researchers have discovered a previously unknown cell-protecting function of a protein, which could open new avenues for treating age-related diseases and lead to healthier aging overall......»»
IBM"s Maximo helps prevent production snags by predicting when machinery needs maintenance
IBM has been expanding Maximo's capabilities to monitor the health of production machinery and tooling by using data to predict when critical maintenance is needed. The goal: Prevent unplanned downtime......»»
Discovery of key protein for biosynthesis of plant defense steroids could enhance pest control strategies
Researchers at the Max Planck Institute for Chemical Ecology have identified GAME15 as a key protein that regulates the biosynthesis of both steroidal glycoalkaloids and steroidal saponins in plants of the genus Solanum......»»
Android 15’s security and privacy features are the update’s highlight
New tools aim at phone snatchers, snooping kids or partners, and cell hijackers. Android 15 started rolling out to Pixel devices Tuesday and will arrive, through various third-par.....»»
Protein signaling pathway provides insights into cell migration and cancer metastasis
The innate immune response is the body's first line of defense against infection, and a successful immune defense takes a village: a combination of physical barriers, chemical attacks, and an army of specialized white blood cells. But maintaining and.....»»
Cryo-electron microscopy sheds light on endothelin signaling mechanisms
Endothelin is a peptide hormone known for its vasoconstrictive effects. Researchers at University of Tsukuba used cryo-electron microscopy to examine the complex structure of the endothelin receptor and G protein, which are crucial for signal transdu.....»»
MicroRNA, Protein Folding and Machine-Learning Work Win the Science Nobels
A roundup of the science Nobels, the latest COVID updates and the Europa Clipper launch delay......»»
AI helps suppliers reduce plant downtime, increase efficiency
Large suppliers including Bosch, Magna and Forvia are investing significant resources in AI tools they say will help them become more nimble......»»
Microtubule formation mechanism sheds light on how cells build their internal skeleton
Inside every cell, a network of tiny filaments, called the microtubule cytoskeleton, helps maintain the cell's shape, allows it to divide, and transports vital materials from one part of the cell to another. The filaments that form this network, term.....»»
Scientists discover chemical probes for previously "undruggable" cancer target
Hormone-driven cancers, like those of the breast and prostate, often rely on a tricky-to-target protein called Forkhead box protein 1 (FOXA1). FOXA1 mutations can enable these types of cancers to grow and proliferate. Today, FOXA1 is notoriously diff.....»»
Glowing proteins enable real-time, 3-D study of essential enzymes
Working in organoid models, researchers at University of California San Diego School of Medicine have developed a new tool to study protein-kinase C (PKC) enzymes, which play a critical role in cell growth, differentiation and survival. Malfunction o.....»»
Calcium transport protein in bacteria offers insights for drug development and food safety
Researchers at Umeå University have revealed details on how bacteria use calcium to regulate vital processes in a way that differs from human cells. This breakthrough is significant in the fight against antibiotic resistance and for increasing safet.....»»