Discovery of a cellular uptake pathway for larger drug molecules
Recent findings by UCSF and Arc Institute scientists open up new possibilities for overcoming a fundamental challenge in drug discovery. There can be a tradeoff between optimizing a drug's key-in-a-lock fit with its target and the drug's ability to m.....»»
Twice as many women as men were buried in the megalithic necropolis of Panoría, study reveals
A multidisciplinary research team led by the Archaeometry research group of the University of Tübingen and the GEA research group of the University of Granada made a surprising discovery in the megalithic necropolis of Panoría (Granada, Spain): twi.....»»
New evolutionary model revises the origins of biodiversity
An international team of scientists has made a discovery that could reshape our understanding of how global biodiversity evolved. By reconstructing the evolution of species over the past 45 million years, researchers found that the geographic origins.....»»
Neutron experiments settle 40-year debate on enzyme for drug design
In just two neutron experiments, scientists discovered remarkable details about the function of an enzyme that can aid drug design for aggressive cancers......»»
11 million devices infected with botnet malware hosted in Google Play
Necro infiltrated Google Play in 2019. It recently returned. Enlarge (credit: Getty Images) Five years ago, researchers made a grim discovery—a legitimate Android app in the Google Play market that was surreptitiously.....»»
Gun violence in Philadelphia plummeted in 2024—researchers aren"t sure why, but here are 3 factors at play
Philadelphia experienced a surge in shootings and homicides during the COVID-19 years that disproportionately affected young Black and Latino men in economically disadvantaged neighborhoods with drug markets......»»
Can our stockpiles of Tamiflu protect against a bird flu pandemic?
Governments are banking on this old drug in the event of an H5N1 outbreak. Enlarge / A box and a tablet of Roche Pharmaceuticals' Tamiflu pills for influenza. (credit: Nikos Pekiaridis/NurPhoto via Getty Images) Since re.....»»
Could stars hotter than the sun still support life?
Although most potentially habitable worlds orbit red dwarf stars, we know larger and brighter stars can harbor life. One yellow dwarf star, for example, is known to have a planet teaming with life, perhaps even intelligent life. But how large and bri.....»»
Apple @ Work: It’s time for Apple to add cellular to the Mac
Apple @ Work is exclusively brought to you by Mosyle, the only Apple Unified Platform. Mosyle is the only solution that integrates in a single professional-grade platform all the solutions necessary to seamlessly and automatically deploy, manage & pr.....»»
Cocaine found in mummified brains reveal that New World drug came to Italy 200 years earlier than thought
Cocaine found in mummified brains reveal that New World drug came to Italy 200 years earlier than thought.....»»
New data science tool greatly speeds up molecular analysis of our environment
A research team led by scientists at the University of California, Riverside, has developed a computational workflow for analyzing large data sets in the field of metabolomics, the study of small molecules found within cells, biofluids, tissues, and.....»»
AI for drug discovery: DrugSynthMC to make finding new medication more efficient
Scientists have devised a free AI algorithm that they believe will make finding new medicines far more efficient......»»
Researchers identify novel endocytic recycling mechanism with "kiss-and-run" membrane fusion
Endocytosis and recycling control the uptake and retrieval of various materials in eukaryotic cells. Mammalian cells have developed several recycling routes, including the relatively extensively studied "fast" and "slow" tubulovesicular recycling pat.....»»
How a bacterial pathogen that causes dysentery manipulates molecular activity to assure its survival
Virginia Tech researchers have learned how bacteria manipulate molecules to infect the host organism. Daniel Capelluto and his research team have discovered the mechanism by which the bacterial pathogen Shigella flexneri, the causative agent of dysen.....»»
Study shows cholesterol enhances exosome-mediated RNA drug delivery
RNA interference (RNAi) technology has gradually become a cutting-edge technology for treating diseases such as genetic disorders and cancer due to its huge potential in gene expression regulation. However, the efficient delivery and safety of short.....»»
Recharging mitochondria—nanoflowers offer a new way to simulate energy production to improve aging ailments
When we need to recharge, we might take a vacation or relax at the spa. But what if we could recharge at the cellular level, fighting against aging and disease with the microscopic building blocks that make up the human body?.....»»
Double-edged STING: A new pathway involved in aging
A protein called STING, previously shown to control a pathway that contributes to antiviral signaling, also plays an important role in cellular stress clearance and cell survival, according to a new paper published in Molecular Cell......»»
Astronomers just detected the biggest black hole jets ever seen—and named them Porphyrion
The largest known black hole jets, 23 million light years across, have been discovered in the distant universe. This pair of particle beams launched by a supermassive black hole is over a hundred times larger than our galaxy, the Milky Way......»»
A drug made by a Florida company has been recalled for a possibly lethal contamination
A drug made by a Florida company has been recalled for a possibly lethal contamination.....»»
Was Thalidomide Safe? Frances Oldham Kelsey Was Not Convinced
In the U.S. in the early 1960s the distributor of a thalidomide drug was impatient to get it on the market. But FDA medical examiner Frances Oldham Kelsey wanted more information to prove its safety.....»»
Ultra-Precise Particle Measurement Narrows Pathway to ‘New Physics’
A long-awaited calculation of the W boson’s mass agrees with theory, contradicting a previous anomaly that had raised the possibility of new physics beyond the Standard Model.....»»