CRISPR now possible in cockroaches
Researchers have developed a CRISPR-Cas9 approach to enable gene editing in cockroaches, according to a study published by Cell Press on May 16th in the journal Cell Reports Methods. The simple and efficient technique, named "direct parental" CRISPR.....»»
New findings on the link between CRISPR gene-editing and mutated cancer cells
A protein that protects cells from DNA damage, p53, is activated during gene editing using the CRISPR technique. Consequently, cells with mutated p53 have a survival advantage, which can cause cancer. Researchers have found new links between CRISPR,.....»»
How to turn specific genes on and off
Type 1 diabetes, rheumatoid arthritis, and cancer are just some of the disorders associated with specific genes not 'turning on' and 'turning off' as they should. By using new CRISPR/Cas9 genome editing technology researchers have described a new tec.....»»
Study encourages cautious approach to CRISPR therapeutics
A comprehensive study has shown that gene editing, specifically gene knockout (KO), with CRISPR-Cas9 can favor cells with mutated forms of genes linked to cancer. The findings highlight the need to monitor patients undergoing CRISPR-Cas9-based gene t.....»»
CRISPR screen identifies new anti-inflammatory drug target
A metabolic enzyme that has been studied in cancer biology and is important for T cell function may offer a new target for anti-inflammatory therapeutics, researchers have discovered. They report that inhibiting or genetically deleting the enzyme, ca.....»»
Researchers develop CRISPR-based rapid diagnostic tool for SARS-CoV-2
,Blending experts from molecular genetics, chemistry and health sciences, researchers at the University of California San Diego have created a rapid diagnostic technology that detects SARS-CoV-2, the coronavirus that causes COVID-19......»»
New tool offers ways to improve CRISPR gene-editing method
The ability to edit the genome by altering the DNA sequence inside a living cell is powerful for research and holds enormous promise for the treatment of diseases. However, existing genome editing technologies frequently result in unwanted mutations.....»»
CRISPR Gene-Editing Experiment Partly Restores Vision In Legally Blind Patients
An anonymous reader quotes a report from NPR: Carlene Knight's vision was so bad that she couldn't even maneuver around the call center where she works using her cane. But that's changed as a result of volunteering for a landmark medical experiment......»»
Taking the guesswork out of genetic engineering: STAMPScreen pipeline helps streamline genetic studies in mammalian cell
Today's genetic engineers have a plethora of resources at their disposal: an ever-increasing number of massive datasets available online, highly precise gene editing tools like CRISPR, and cheap gene sequencing methods. But the proliferation of new t.....»»
Eliminating beef cattle pregnancy loss with CRISPR/Cas9 technology
Calves on the ground eventually mean dollars in the pocket and steaks in the meat case. It's the basics of the beef industry......»»
RNA-targeting enzyme expands the CRISPR toolkit
Researchers at MIT's McGovern Institute for Brain Research have discovered a bacterial enzyme that they say could expand scientists' CRISPR toolkit, making it easy to cut and edit RNA with the kind of precision that, until now, has only been availabl.....»»
How Colossal sold investors on a quest to resurrect a woolly mammoth
There are a growing number of companies interested in CRISPR’s potential to upend medicine. It’s probably safe to say there’s only one company interested in using the gene-editing system to create a living, breathing woolly mammoth. Or, at.....»»
New CRISPR-based technology to speed identification of genes involved in health and disease
Zebrafish—small, fast-growing creatures who share many of the same genes as humans—are instrumental to many biologists, who find them uniquely well suited for studying a wide range of questions, from how organisms develop to how the nervous syste.....»»
International Space Station experiment expands DNA research toolkit using CRISPR
Studying DNA repair is key to future space exploration, which could expose humans to risk of DNA damage caused by radiation. Conditions in space also could affect the way the body repairs such damage, potentially compounding that risk......»»
New CRISPR-based technology could revolutionize antibody-based medical diagnostics
Scientists have repurposed the genetic modification technology CRISPR to identify antibodies in patient blood samples in a move that could inspire a new class of medical diagnostics in addition to a host of other applications......»»
New CRISPR/Cas9 technique corrects cystic fibrosis in cultured human stem cells
Researchers from the group of Hans Clevers (Hubrecht Institute) corrected mutations that cause cystic fibrosis in cultured human stem cells. In collaboration with the UMC Utrecht and Oncode Institute, they used a technique called prime editing to rep.....»»
From CRISPR to glowing proteins to optogenetics, the most powerful technologies are borrowed from nature
Watson and Crick, Schrödinger and Einstein all made theoretical breakthroughs that have changed the world's understanding of science......»»
Using two CRISPR enzymes, a COVID diagnostic in only 20 minutes
Frequent, rapid testing for COVID-19 is critical to controlling the spread of outbreaks, especially as new, more transmissible variants emerge......»»
Two new transgenic mouse lines will enable innovative studies into gene regulation
A CRISPR-Cas9 variant with deactivated DNA-cutting function—known as "dCas9"—is a powerful tool to help researchers understand what genes do when their expression is dialed up or down, but it has some limitations......»»
Scientists boost gene knockdown in human cells with CRISPR-Cas13 using chemically modified guide RNAs
In the latest of ongoing efforts to expand technologies for modifying genes and their expression, researchers in the lab of Neville Sanjana at New York University (NYU) and the New York Genome Center (NYGC) have developed chemically modified guide RN.....»»
Scientists harness the naturally abundant CRISPR-Cas system to edit superbugs
A research team led by Dr. Aixin Yan, Associate Professor from the Research Division for Molecular & Cell Biology, Faculty of Science, in collaboration with Honorary Clinical Professor Patrick Cy Woo from the Department of Microbiology, Li Ka Shing F.....»»