CRISPR now possible in cockroaches
Researchers have developed a CRISPR-Cas9 approach to enable gene editing in cockroaches, according to a study published by Cell Press on May 16th in the journal Cell Reports Methods. The simple and efficient technique, named "direct parental" CRISPR.....»»
CROPSR: A new tool to accelerate genetic discoveries
Scientists have developed CROPSR, the first open-source software tool for genome-wide design and evaluation of guide RNA (gRNA) sequences for CRISPR/Cas9 experiments. This tool significantly shortens the time required to design a CRISPR experiment an.....»»
New Cas9 model maps DNA cutting behavior for the first time
Researchers from the TU Delft have come up with a physical-based model that establishes a quantitative framework on how gene-editing with CRISPR-Cas9 works, and allows them to predict where, with what probability, and why targeting errors (off-target.....»»
A potential therapy for muscular dystrophy: Using mRNA delivery to improve muscle strength
Mutations that lead to muscle atrophy can be repaired with the gene editor CRISPR-Cas9. A team led by ECRC researcher Helena Escobar has now introduced the tool into human muscle stem cells for the first time using mRNA, thus discovering a method sui.....»»
Beyond CRISPR: New DNA tools rewrite genes to fight diseases like COVID-19
When Emmanuelle Charpentier and Jennifer Doudna won the Nobel Prize in Chemistry in 2020, their CRISPR gene editor had revolutionized medicine, agriculture, and genetics in just a few short years. But already, plans were in the works to move beyond C.....»»
Protein Tweak Makes CRISPR Gene Editing 4,000 Times Less Error-Prone
Researchers at the University of Texas at Austin have identified a previously unknown structure of the protein that's responsible for making edits to the wrong sections of DNA. After some tweaking, they were able to reduce the likelihood of off-targe.....»»
AI-Designed Protein Awakens Silenced Genes, One By One
By combining CRISPR technology with a protein designed with artificial intelligence, it is possible to awaken individual dormant genes by disabling the chemical "off switches" that silence them. Researchers from the University of Washington School of.....»»
AI-designed protein awakens silenced genes, one by one
By combining CRISPR technology with a protein designed with artificial intelligence, it is possible to awaken individual dormant genes by disabling the chemical "off switches" that silence them. Researchers from the University of Washington School of.....»»
Advancing genome editing through studying DNA repair mechanisms
Since the discovery of CRISPR/Cas9, also known as molecular scissors, scientists around the world have been working to improve the revolutionary technique for altering DNA that earned Emmanuelle Charpentier and Jennifer Doudna the Nobel Prize in 2020.....»»
Could Crispr Flip the Switch on Insecticide Resistance?
Many insects, like the mosquitoes that spread malaria, have evolved a tolerance to chemical sprays. What if we could reboot their genes?.....»»
Scientists expand CRISPR-Cas9 genetic inheritance control in mammals
Nearly three years ago University of California San Diego researchers announced the world's first CRISPR-Cas9 genetic editing-based approach to controlling inheritance in mammals......»»
Researchers pioneer new method to edit genes in human cells
Over the past decade, the CRISPR genome-editing system has revolutionized molecular biology, giving scientists the ability to alter genes inside living cells for research or medical applications. Now, researchers at Gladstone Institutes have fine-tun.....»»
Researchers develop specific and sensitive Cas12c-based nucleic acid detection platform
The prokaryotic clustered regularly interspaced short palindromic repeat (CRISPR) and CRISPR-associated (CRISPR/Cas) protein system has been reconstructed for a revolutionary targeted genome modification platform and nucleic acid detection tool. Rest.....»»
Breakthrough in using CRISPR-Cas9 to target fat cells
Researchers describe a breakthrough using CRISPR-Cas9, a tool that has transformed molecular biological research, but whose use in the study of adipose tissue had been elusive......»»
Team achieves breakthrough using CRISPR-Cas9 to target fat cells
Fat—it is tvital for life but too much can lead to a host of health problems. Studying how fat—or adipose—tissue functions in the body is critical for understanding obesity and other issues, yet structural differences in fat cells and their dis.....»»
New biosensors shine a light on CRISPR gene editing
Detecting the activity of CRISPR gene editing tools in organisms with the naked eye and an ultraviolet flashlight is now possible using new technology......»»
New biosensors shine a light on CRISPR gene editing
Detecting the activity of CRISPR gene editing tools in organisms with the naked eye and an ultraviolet flashlight is now possible using technology developed at the Department of Energy's Oak Ridge National Laboratory......»»
CRISPRing the microbiome is just around the corner
CRISPR is widely used to target specific cell types, but only one at a time. Researchers have now developed methods to edit genes in multiple organisms within a diverse community of microbes simultaneously, a first step toward editing microbiomes suc.....»»
CRISPR/Cas9 gene editing boosts effectiveness of ultrasound cancer therapy
Sonodynamic therapy uses ultrasound in combination with drugs to release harmful reactive oxygen species (ROS) at the site of a tumor. However, the treatment isn't very effective because cancer cells can activate antioxidant defense systems to counte.....»»
CRISPRing the microbiome is just around the corner
To date, CRISPR enzymes have been used to edit the genomes of one type of cell at a time: They cut, delete or add genes to a specific kind of cell within a tissue or organ, for example, or to one kind of microbe growing in a test tube......»»
Potential new gene editing tools uncovered
Few developments have rocked the biotechnology world or generated as much buzz as the discovery of CRISPR-Cas systems, a breakthrough in gene editing recognized in 2020 with a Nobel Prize. But these systems that naturally occur in bacteria are limite.....»»