Biosynthesis pathway of a new DNA nucleobase elucidated
DNA is composed of nucleobases represented by the letters A, T, G and C. They form the basis of the genetic code and are present in all living beings. But in a bacteriophage, another base, represented by the letter Z, exists. This exception, the only.....»»
Deadly virus"s pathway to infect cells identified
Rift Valley fever virus causes economically devastating outbreaks of hemorrhagic fever in livestock such as sheep, goats and cattle. These mosquito-borne outbreaks lead to infection in people working with dead or dying animals, sometimes causing hund.....»»
Extremists using video-game chats to spread hate
Campaigners say including extremist narratives among everyday conversations can be a pathway to radicalisation......»»
Noninvasive eye procedure provides potential pathway for virus, disease carriers
A common eye test could expel tear droplets up to a meter away from the patient, potentially spreading viruses that cause COVID-19 and other pathogens......»»
A pathway to stable, high-activity catalysts from gold nanoclusters
Catalysts are ubiquitous, whether in the form of an enzyme in the body that digests food or the catalytic converter in the car that breaks down pollutants. Catalysts play an important role in making chemical reactions more efficient. Recently, atomic.....»»
Aduhelm approval sparks HHS watchdog review of FDA’s accelerated approval pathway
The Department of Health and Human Services (HHS) Office of the Inspector General will review the FDA’s accelerated approval pathway, the office announced Wednesday. This sweeping review comes just two months after the controversial approval of Bio.....»»
New pathway to mitigate climate change and boost progress on UN Sustainable Development Goals
A world that combats climate change while simultaneously improving on all 17 Sustainable Development Goals (SDGs) is possible, a new study finds. Scientists from the Potsdam Institute for Climate Impact Research (PIK) and the German Development Insti.....»»
Scientists turn methane into methanol at room temperature
A team of researchers from Stanford University and the University of Leuven in Belgium has further elucidated an intriguing process that could be an important step toward a methanol fuel economy with abundant methane as the feedstock, an advance that.....»»
Electric signals between individual cardiac cells regulate heartbeat
Researchers provide an update on how electrical impulses in the heart travel from cell to cell. The connections between cells forming the low resistance pathway and facilitating the current flow are called gap junctions. Each consists of many channel.....»»
Biosynthesis pathway of a new DNA nucleobase elucidated
DNA is composed of nucleobases represented by the letters A, T, G and C. They form the basis of the genetic code and are present in all living beings. But in a bacteriophage, another base, represented by the letter Z, exists. This exception, the only.....»»
Discovery shows how tuning the immune system may enhance vaccines and ease disease
A metabolic control pathway that regulates T follicular helper cells offers targets for drugs to stimulate the adaptive immune response......»»
New signaling pathway could shed light on damage repair during brain injury
An observational study conducted using Drosophila fruit flies has uncovered a signaling pathway that causes neural cells to enter divisions after damage. The research is important because the signaling kinases are also seen activated in human Alzheim.....»»
A novel strategy for natural product biosynthesis
Microorganisms produce natural products, for example, as disease-causing virulence factors or as defense substances against predators and competitors. A team led by Dr. Robin Teufel and first author Ying Duan from the Institute of Biology II at the F.....»»
"Unlocking" the potential of viruses to fight cancer
Researchers have elucidated the mechanism through which the H-1PV cancer-destroying virus can cause cell lysis and death. At the heart of this process lie laminins, and specifically laminin gamma 1, a family of proteins on the surface of a cancer cel.....»»
A promising new pathway to treating type 2 diabetes
Researchers believe the liver may hold the key to new, preventative Type 2 diabetes treatments......»»
"Edge of chaos" opens pathway to artificial intelligence discoveries
Scientists at the University of Sydney and Japan's National Institute for Material Science (NIMS) have discovered that an artificial network of nanowires can be tuned to respond in a brain-like way when electrically stimulated......»»
Structural uniqueness of the green- and red-light sensing photosensor in cyanobacteria
Certain cyanobacteria can change the absorbing light colors for photosynthesis using a green- and red-light sensing photosensor protein. A Japanese research group elucidated the molecular structure of RcaE, a representative member of the photosensors.....»»
Researchers rewire the genetics of E. coli, make it virus-proof
A revised genetic code is a pathway for bacteria to do things that seem unnatural. Enlarge / On the outside, these heavily engineered bacteria look no different from their normal peers. (credit: Raphael Gaillarde / Getty Images) Many of the f.....»»
Study polypharmacology earlier in drug discovery, say researchers
Polypharmacology—the ability of a drug to affect more than one protein—should be studied early in the drug discovery pathway, and constantly monitored as the chemical structure is optimized in the design of the clinical candidate, leading researc.....»»
Researchers identify molecular mechanism of terpenoid biosynthesis in sand rice
As a pioneer plant of the mobile and semi-mobile sand dunes in arid and semi-arid region, Agriophyllum squarrosum, also called "sand rice", is a folk Mongolian medicine with pleiotropic pharmacological and ecological economic importance endemic to As.....»»
Plant flowering in low-nitrogen soils: A mechanism revealed
Scientists from Japan, Europe and the USA have described a pathway leading to the accelerated flowering of plants in low-nitrogen soils. These findings could eventually lead to increases in agricultural production......»»