Activation of prodrug using protein-encased gold catalyst
As part of their efforts to devise ways to minimize the side effects of drugs for treating cancer, four RIKEN chemists have found a biocompatible way to convert compounds with low biological activity into anticancer drugs at tumors1......»»
Simulation model shows ribosome tunnel"s impact on protein structures
Researchers at University of Tsukuba have developed a new model that simulates the internal environment of a ribosome—the cellular site of protein synthesis. Using computer simulations, they have analyzed the structures of various proteins within t.....»»
Addigy launches Apple Intelligence device management controls
Apple device management vendor Addigy has announced the immediate availability of new Apple Intelligence controls. These controls, now live within Addigy’s platform, allow IT administrators and Managed Service Providers to test the activation and d.....»»
Dual protein analysis approach provides potential way to slow cancer growth
Fighting cancer effectively often involves stopping cancer cells from multiplying, which requires understanding proteins that the cells rely on to survive. Protein profiling plays a critical role in this process by helping researchers identify protei.....»»
Dissecting caspase-2-mediated cell death: From intrinsic PIDDosome activation to chemical modulation
Caspase-2, an initiator caspase, plays a critical role in programmed cell death in response to certain cellular stresses. Its activation is facilitated by the PIDDosome, a multi-protein complex that assembles under conditions of genotoxic stress. Des.....»»
NatGeo’s Cursed Gold documents rise and fall of notorious 1980s treasure hunter
Thompson's expedition discovered wreck of the SS Central America, aka the "Ship of Gold." Enlarge / Cursed Gold: A Shipwreck Scandal documents the spectacular rise and fall of treasure hunter Tommy Thompson. (credit: Recovery Lim.....»»
Research unravels dual role of membrane protein in rice ethylene signal transduction
A research team, led by Professor Zhang Jinsong from the Institute of Genetics and Developmental Biology (IGDB) of the Chinese Academy of Sciences, revealed insights into the mechanism by which the membrane protein MHZ3 collaborates with the ethylene.....»»
Peloton announces $95 “used equipment activation fee”
"Completely ridiculous." Enlarge (credit: Peloton) Peloton will start charging people a one-time $95 "used equipment activation fee" for used bikes purchased from outside of Peloton and its official distribution partner.....»»
A small molecular glue that increases P53 level and suppresses tumor growth in vivo
Molecular glues are typically small chemical molecules that act on the interface between the target protein and the degradation machinery to trigger ternary complex formation. Identification of molecular glues is challenging, and there has been a lac.....»»
The Green Economy Is Hungry for Copper—and People Are Stealing, Fighting, and Dying to Feed It
With the possible exception of gold, no other metal has caused as much destruction as copper. In the coming years, we’ll need more of it than ever......»»
Cryo-ET study elucidates protein folding helpers in their natural environment
Cryo-electron tomography (cryo-ET), can be used to visualize and analyze cellular structures in their natural environment. Researchers at the MPI of Biochemistry in Martinsried and the University Medical Center Göttingen have now used cryo-ET to stu.....»»
Comparing methods for extracting edible protein from mealworms
Edible insects are emerging as an alternative protein source that has various benefits compared with conventional animal sources. New research published in the Journal of Food Science compared four different methods for extracting protein from mealwo.....»»
Researchers teach artificial intelligence about frustration in protein folding
Scientists have found a new way to predict how proteins change their shape when they function, which is important for understanding how they work in living systems. While recent artificial intelligence (AI) technology has made it possible to predict.....»»
The Quest to Uncover the Secrets of Gold Hydrogen
Industries want to harvest naturally occurring hydrogen as soon as possible, but scientists warn of unforeseen consequences......»»
Strategies for security leaders: Building a positive cybersecurity culture
Culture is a catalyst for security success. It can significantly reduce cybersecurity risks and boost cybersecurity resilience of any organization. Culture can also greatly enhance the perceived value, relevance and reputation of the cybersecurity fu.....»»
New leak suggests fourth iPhone 16 Pro lineup color is more "dark gold" than "brown"
A new photo from frequent leaker Maijin Bu on X.com shows color samples purported to be from the forthcoming iPhone 16 Pro lineup. The report suggests that earlier photos of a brownish "desert titanium" option may be misleading.The iPhone 16 Pro line.....»»
Exploring Huntington"s disease: Researchers discover that protein aggregates poke holes in the nuclear membrane
Researchers at Utrecht University in the Netherlands have identified a new way in which the toxic protein aggregates associated with Huntington's disease may damage nerve cells and cause them to die......»»
Newly discovered protein stops DNA damage
Researchers from Western University have discovered a protein that has the never-before-seen ability to stop DNA damage in its tracks. The finding could provide the foundation for developing everything from vaccines against cancer, to crops that can.....»»
Surprise finding in study of environmental bacteria could advance search for better antibiotics
In what they labeled a "surprising" finding, Johns Hopkins Medicine researchers studying bacteria from freshwater lakes and soil say they have determined a protein's essential role in maintaining the germ's shape. Because the integrity of a bacterial.....»»
Light-responsive gene regulation at the mRNA level
Researchers at the University of Bayreuth have established a new optogenetic approach that can control the bacterial production of proteins at the mRNA level using blue light. The new system gates the activation of the genetic substance particularly.....»»
AI, computation, and the folds of life: Supercomputers help train a software tool for the protein modeling community
Form follows function, and this is especially true for life's building blocks—proteins. The folds and shape of molecular proteins reveal their function in supporting life......»»