"Undruggable" cancer protein becomes druggable, thanks to shrub
A chemist from Purdue University has found a way to synthesize a compound to fight a previously "undruggable" cancer protein with benefits across a myriad of cancer types......»»
New study details how starving cells hijack protein transport stations
A new study details how nutrient-starved cells divert protein transport stations to cellular recycling centers to be broken down, highlighting a novel approach cells use to deal with stressful conditions......»»
Researchers develop method to extract useful proteins from beer-brewing leftovers
Researchers from Nanyang Technological University, Singapore (NTU Singapore), have created a method that extracts more than 80% of the available protein in grain leftovers from brewing beer, commonly known as brewers' spent grain......»»
Scientists find new ways to convert inhibitors into degraders, paving the way for future drug discoveries
Researchers have discovered ways to convert inhibitor-style targeted cancer drugs into small molecules known as degraders, which help destroy cancer-promoting proteins in cells......»»
A new tool for tracing the family trees of cells
EPFL researchers have developed GEMLI, a pioneering tool that could democratize and vastly improve how we study the journey of cells from their embryonic state through to specialized roles in the body, as well as their changes in cancer and other dis.....»»
A promising target for new RNA therapeutics now accessible
Only recently, a new era in medicine began with the first RNA vaccines. These active substances are modified RNAs that trigger immune responses of the human immune system. Another approach in RNA medicine targets the body's own RNA and its protein mo.....»»
New protein imaging method supports the design of innovative new cancer drugs
Scientists have successfully used a new imaging technique to determine the structure and interactions of a protein complex that plays a significant part in the initiation and progression of cancer. They showed that it was possible to use a high-resol.....»»
EPA seeks to cut “Cancer Alley” pollutants
Chemical plants will have to monitor how much is escaping and stop leaks. Enlarge / An oil refinery in Louisiana. Facilities such as this have led to a proliferation of petrochemical plants in the area. (credit: Art Wager).....»»
A targeted polymer to treat colorectal cancer liver metastases
A nanosized polymer, developed by a research team from Ben-Gurion University of the Negev, can selectively deliver chemotherapeutic drugs to blood vessels that feed tumors and metastases and has emerged as an effective treatment for advanced cancer......»»
Scientists report that buffer and pH strongly affect the phase separation of SARS-CoV-2 N protein
In a new paper published in Molecular Biology of the Cell, the Allain lab (IBC) reported that the phase separation of the SARS-CoV-2 N protein strongly depends on the chosen buffer and pH. For example, the protonation of a single histidine side chain.....»»
New micromaterial releases nanoparticles that selectively destroy cancer cells
Researchers have developed micromaterials made up only of proteins, capable of delivering over an extended period of time nanoparticles that attack specific cancer cells and destroy them. The micromaterials mimic natural secretory granules found in t.....»»
New method reveals secrets of protein interactions with potential for drug discovery
Scientists from the University of Oulu (Finland) and Texas A&M University (U.S.), have developed a new method to study how proteins interact with small ligand molecules, paving the way, for example, for faster and more efficient drug discovery......»»
New study paves the way for precision drugs to treat blood cancers
The Janus kinase 2 (JAK2) protein mediates signaling from several cytokine receptors in the regulation of hematopoiesis and immune responses. Somatic mutations in human JAK2 lead to constitutive activation and cytokine-independent signaling and under.....»»
Chinese scientists reveal the spinning mechanism of the silkworm
Mulberry silk is a natural protein fiber that is light, soft and fine in nature, known as the "second skin of the human body" and "Queen of fibers." China is the origin of the world's sericulture industry......»»
Chemists discover a key protein in how lysosomes work
Lysosomes, often reductively referred to as the "garbage disposals" of cells, play a pivotal role in our cells' digestive systems by getting rid of unwanted materials......»»
New synthesis platform allows for rapid cancer drug synthesis and testing
Imperial College London researchers have developed a new platform for the synthesis, analysis and testing of new compounds which may one day treat cancer. The findings are published in the journal Angewandte Chemie International Edition......»»
Study identifies protein responsible for gas vesicle clustering in bacteria
Gas vesicles are hollow structures made of protein found in the cells of certain microorganisms, and researchers at Rice University believe they can be programmed for use in biomedical applications......»»
Former NADA Chairman Jack Kain dies at 94
Former NADA chairman Jack Kain, 94, died Tuesday from complications with cancer, a family member confirmed to Automotive News......»»
Memories of mitosis: Molecular mechanism that detects defects during cell division could aid cancer treatment
Every day, our cells are hard at work multiplying. Cell division is a precise process, but sometimes this process is impaired and diseases like cancer occur. Mitosis is one of the most important phases in the cell cycle. During this phase, a cell's D.....»»
Researcher creates algorithm to aid in discovery of new medicines
Ph.D. candidate Jeroen Methorst has developed a computer system that helps researchers find the protein they need to create new medicines. "Our whole group is now using this program," says Methorst. He will defend his Ph.D. thesis on April 2......»»
The Next Generation of Cancer Drugs Will Be Made in Space
Injectable immunotherapy drugs can be made, in theory, but gravity prevents them from crystallizing correctly. A startup thinks the solution could be right above us......»»