"Undruggable" cancer protein becomes druggable, thanks to shrub
A chemist from Purdue University has found a way to synthesize a compound to fight a previously "undruggable" cancer protein with benefits across a myriad of cancer types......»»
DeepMind adds a diffusion engine to latest protein-folding software
Major under-the-hood changes let AlphaFold handle protein-DNA complexes and more. Enlarge / Prediction of the structure of a coronavirus Spike protein from a virus that causes the common cold. (credit: Google DeepMind) M.....»»
MATE transporter facilitates bitter saponin transport from cytoplasm to vacuole
Domestic soybeans serve as an important source of healthy edible plant oil and high-quality plant protein in our food culture. In addition to the well-known components of oil (approximately 20%), protein (approximately 40%), and carbohydrates (approx.....»»
Researchers discover new function of oncoproteins
Researchers at the University of Würzburg have discovered a new function of the oncoprotein MYCN: It not only helps cancer cells to grow stronger, but also makes them more resistant to drugs. The study is published in Molecular Cell......»»
Study sheds light on cancer cell "tug-of-war"
Understanding how cancerous cells spread from a primary tumor is important for any number of reasons, including determining the aggressiveness of the disease itself. The movement of cells into the extracellular matrix (ECM) of neighboring tissue is a.....»»
Laboratory and natural strains of intestinal bacterium turn out to have similar mutational profiles
Understanding mutational processes in a cell offers clues to the evolution of a genome. Most actively, mutation processes are studied in human cancer cells, while other genomes are often neglected......»»
Dogma-challenging telomere findings may offer new insights for cancer treatments
A new study led by University of Pittsburgh and UPMC Hillman Cancer Center researchers shows that an enzyme called PARP1 is involved in repair of telomeres, the lengths of DNA that protect the tips of chromosomes, and that impairing this process can.....»»
Geologists, biologists unearth the atomic fingerprints of cancer
Scientists at the University of Colorado Boulder and Princeton University have, for the first time, employed a tool often used in geology to detect the atomic fingerprints of cancer......»»
Researchers develop a nanoparticle that can penetrate the blood-brain barrier
Researchers at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine have developed a nanoparticle that can penetrate the blood-brain barrier. Their goal is to kill primary breast cancer tumors and brain metastase.....»»
Scientists use high pressure NMR spectroscopy to study structure of dynamic proteins
A pressure of 3,000 bar is applied to the cold shock protein B of Bacillus subtilis in a small tube in the NMR spectroscopy laboratory at the University of Konstanz. This is roughly three times the water pressure at the deepest point of the ocean. Th.....»»
Synthetic chemistry approach yields new compounds with potential biomedical applications
Researchers at Rice University have successfully synthesized a group of natural compounds known as fusicoccanes. The molecules found in various living organisms exhibit diverse biological activities, including the ability to modulate protein-protein.....»»
Simulated chemistry: New AI platform designs tomorrow"s cancer drugs
Scientists at UC San Diego have developed a machine learning algorithm to simulate the time-consuming chemistry involved in the earliest phases of drug discovery, which could significantly streamline the process and open doors for never-before-seen t.....»»
New discovery of a mechanism that controls cell division
Researchers at Umeå University, Sweden, have discovered that how a special protein complex called the Mediator moves along genes in DNA may have an impact on how cells divide. The discovery may be important for future research into the treatment of.....»»
Nano-drugs hitching a ride on bacteria could help treat pancreatic cancer
Many pancreatic tumors are like malignant fortresses, surrounded by a dense matrix of collagen and other tissue that shields them from immune cells and immunotherapies that have been effective in treating other cancers. Employing bacteria to infiltra.....»»
Understanding cellular transcription responses to oxygen deprivation
A multiprotein complex is essential for regulating cellular responses to oxygen deprivation, a key feature of cancer, according to a Northwestern Medicine study published in the Proceedings of the National Academy of Sciences......»»
Study reveals cancer vulnerabilities in popular dog breeds
Medium-sized dogs have a higher risk of developing cancer than the very largest or smallest breeds, according to a UC Riverside study......»»
Microgravity-grown crystals reveal new insights into protein structures
Biochemists have long been working around a blind spot when it comes to proteins. They know that hydrogen constitutes nearly half of the atoms in proteins, but how they contribute to protein function in these complex structures has been less clear. H.....»»
Researchers develop tiny droplets that harness laser light to detect disease markers
A team of researchers led by Nanyang Technological University, Singapore (NTU Singapore) has created tiny droplets that, when activated by laser light, can detect viral protein biomarkers indicating the presence of certain diseases......»»
Bacteria "nanowires" could help develop green electronics
Engineered protein filaments originally produced by bacteria have been modified by scientists to conduct electricity. In a study published recently in the journal Small, researchers revealed that protein nanowires—which were modified by adding a si.....»»
Fruit fly helps unlock clues about how organs, tissue and cancer grow
The fruit fly, Drosophila, has been used by scientists for more than 100 years to unravel key features of life on Earth, such as how animals respond to the sun and how the bodies of animals are patterned from head to tail......»»
Researchers decipher how an enzyme modifies the genetic material in the cell nucleus
Inside the cell nucleus, the DNA molecule is found in a densely packed DNA-protein complex known as chromatin. Here the DNA is wrapped around a core of histone proteins and densely packed to form nucleosomes. The structure of the nucleosomes determin.....»»