Revealing structural secrets of a key cancer protein
Scientists have breathed new life into the study of a protein with an outsized link to human cancers because of its dangerous mutations, using advanced research techniques to detect its hidden regions......»»
MATE transporter facilitates bitter saponin transport from cytoplasm to vacuole
Domestic soybeans serve as an important source of healthy edible plant oil and high-quality plant protein in our food culture. In addition to the well-known components of oil (approximately 20%), protein (approximately 40%), and carbohydrates (approx.....»»
Researchers discover new function of oncoproteins
Researchers at the University of Würzburg have discovered a new function of the oncoprotein MYCN: It not only helps cancer cells to grow stronger, but also makes them more resistant to drugs. The study is published in Molecular Cell......»»
Proton-lithium interactions model lays the foundation for unlocking the secrets of stellar reactions
The reactions between protons and lithium isotopes, especially lithium-6, are pivotal for several domains ranging from nuclear energy applications to astrophysics. The detailed understanding of these interactions aids in improving models for neutron.....»»
Discovery of structural specialization in myriapod ovaries
Elaborate observations reveal the structural specialization within an epithelial layer covering oocytes in the Japanese pill-millipede, Hyleoglomeris japonica, considered absent in Myriapoda. Comparing this result with previous descriptions suggested.....»»
Study sheds light on cancer cell "tug-of-war"
Understanding how cancerous cells spread from a primary tumor is important for any number of reasons, including determining the aggressiveness of the disease itself. The movement of cells into the extracellular matrix (ECM) of neighboring tissue is a.....»»
Laboratory and natural strains of intestinal bacterium turn out to have similar mutational profiles
Understanding mutational processes in a cell offers clues to the evolution of a genome. Most actively, mutation processes are studied in human cancer cells, while other genomes are often neglected......»»
Unraveling isopods" culinary secrets and why it matters for ecosystems
New research on desert isopods' dietary preferences is the revelation of the complex factors influencing their food choices. By understanding how these animals meticulously regulate their nutrient intake and prefer biological soil crusts over plant l.....»»
Bio-inspired materials" potential for efficient mass transfer boosted by a new twist on a century-old theory
The natural vein structure found within leaves—which has inspired the structural design of porous materials that can maximize mass transfer—could unlock improvements in energy storage, catalysis, and sensing thanks to a new twist on a century-old.....»»
Dogma-challenging telomere findings may offer new insights for cancer treatments
A new study led by University of Pittsburgh and UPMC Hillman Cancer Center researchers shows that an enzyme called PARP1 is involved in repair of telomeres, the lengths of DNA that protect the tips of chromosomes, and that impairing this process can.....»»
Mercedes dealership sued for allegedly not revealing used car had flood damage
A customer has accused a South Carolina dealership group of fraud, negligence, breach of contract and a consumer protection law violation for failing to disclose the used 2018 Mercedes-Benz E300 she bought had flood damage......»»
Geologists, biologists unearth the atomic fingerprints of cancer
Scientists at the University of Colorado Boulder and Princeton University have, for the first time, employed a tool often used in geology to detect the atomic fingerprints of cancer......»»
Researchers develop a nanoparticle that can penetrate the blood-brain barrier
Researchers at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine have developed a nanoparticle that can penetrate the blood-brain barrier. Their goal is to kill primary breast cancer tumors and brain metastase.....»»
Two facilities team up for structural biology advances with X-ray free-electron lasers and exascale computing
Plans to unite the capabilities of two cutting-edge technological facilities promise to usher in a new era of dynamic structural biology. Through DOE's Integrated Research Infrastructure, or IRI, initiative, the facilities will complement each other'.....»»
Scientists use high pressure NMR spectroscopy to study structure of dynamic proteins
A pressure of 3,000 bar is applied to the cold shock protein B of Bacillus subtilis in a small tube in the NMR spectroscopy laboratory at the University of Konstanz. This is roughly three times the water pressure at the deepest point of the ocean. Th.....»»
Synthetic chemistry approach yields new compounds with potential biomedical applications
Researchers at Rice University have successfully synthesized a group of natural compounds known as fusicoccanes. The molecules found in various living organisms exhibit diverse biological activities, including the ability to modulate protein-protein.....»»
Simulated chemistry: New AI platform designs tomorrow"s cancer drugs
Scientists at UC San Diego have developed a machine learning algorithm to simulate the time-consuming chemistry involved in the earliest phases of drug discovery, which could significantly streamline the process and open doors for never-before-seen t.....»»
Astronomers observe elusive stellar light surrounding ancient quasars
MIT astronomers have observed the elusive starlight surrounding some of the earliest quasars in the universe. The distant signals, which trace back more than 13 billion years to the universe's infancy, are revealing clues to how the very first black.....»»
The surprise is not that Boeing lost commercial crew but that it finished at all
"The structural inefficiency was a huge deal." Enlarge / Boeing's Starliner spacecraft is lifted to be placed atop an Atlas V rocket for its first crewed launch. (credit: United Launch Alliance) NASA's senior leaders in.....»»
Kingdom Hearts 4: release date, trailers, gameplay, and more
This sequel's full picture isn't clear as of yet, but we've done our best to unlock all the secrets we can and share everything we know about Kingdom Hearts 4......»»
Earth from space: Namibian landforms
This image may resemble the surface of Mars, but it was actually captured by the Copernicus Sentinel-2 mission, revealing the stunning terrain of northwest Namibia......»»