Zeroing in on the workings of tumor suppressor protein p53, the "guardian of the genome"
The tumor suppressor protein p53 has been dubbed the "guardian of the genome" because it protects the DNA from stress or long-term damage by regulating the expression of numerous genes involved DNA repair, cell division and cell death. Now, FMI resea.....»»
New method developed to relocate misplaced proteins in cells
Cells are highly controlled spaces that rely on every protein being in the right place. Many diseases, including cancers and neurodegenerative disorders, are associated with misplaced proteins. In some cancers, for instance, a protein that normally s.....»»
Double-edged STING: A new pathway involved in aging
A protein called STING, previously shown to control a pathway that contributes to antiviral signaling, also plays an important role in cellular stress clearance and cell survival, according to a new paper published in Molecular Cell......»»
Genome sequence analysis identifies new driver of antimicrobial resistance
Antibiotics are a lifesaving tool. Yet, due to their chronic overuse, microbes are evolving and developing immunity against them. As a result, once-effective medications can no longer stave off infections, complicating treatment and increasing mortal.....»»
Human genome stored on "everlasting" memory crystal
University of Southampton scientists have stored the full human genome on a 5D memory crystal—a revolutionary data storage format that can survive for billions of years......»»
Plant pathogen battle: A tomato protein"s dual role in defense and susceptibility
Tomatoes, a staple crop worldwide, are increasingly threatened by biotic stressors such as viruses, fungi, and bacteria, with the effects worsening under climate change. These challenges lead to reduced yields and compromised nutritional quality, hig.....»»
Surgeons Identify—And Save—A Patient’s Chess-Playing Brain Area
Neuroscientists at the University of Barcelona set about on a search for brain areas involved in chess-related tasks so that surgeons could avoid them when removing a tumor.....»»
An unexpected protein connection in maize growth and defense could enhance crop resilience
Maize (corn) is one of the most important staple crops in the world and has been extensively studied. Yet, many aspects of the genetic mechanisms regulating its growth and development remain unexplored......»»
Team discovers naturally occurring DNA-protein hybrids
Thanks to a serendipitous discovery and a lot of painstaking work, scientists can now build biohybrid molecules that combine the homing powers of DNA with the broad functional repertoire of proteins—without having to synthesize them one by one, res.....»»
Scientists from 33 European countries join forces to generate reference genomes for the continent"s biological diversity
In a new publication, the European Reference Genome Atlas (ERGA) announces the success of its pilot project. This initiative assembled a large collaborative network of scientists and institutions across 33 countries to produce high-quality reference.....»»
Scientists discover how TGF-Beta sends its message even while tethered to the cell membrane
For years, scientists have thought that TGF-Beta, a signaling protein that holds sway over an astonishing array of cellular processes from embryonic development to cancer, could only do its work once it escaped a lasso-like "straitjacket.".....»»
Ethics of biobanking for conservation: Researchers adjust ethical assessment tool for the use of genome research banks
In the face of the global biodiversity crisis, more and more biobanks are being set up to safeguard and potentially restore genetic diversity. Preserved tissue or cells allow scientists and conservationists to overcome spatial and even temporal fragm.....»»
Edible insects show promise as sustainable nutritional source
As the global population grows and traditional livestock production increasingly strains environmental resources, there is a rising interest in alternative protein sources. Edible insects, particularly grasshoppers, are abundant in regions like Camer.....»»
The olive tree"s blueprint: Key insights into high-quality oil production
A pivotal study has decoded the genetic basis of olive oil production, revealing a key regulatory mechanism that shapes oil biosynthesis. By mapping the olive tree's genome and metabolic pathways, researchers have identified how MYC2, a critical tran.....»»
Genomic analysis confirms the uniqueness of Iberian red deer in Europe
A genome study of more than 700 European red deer has identified four distribution areas on the continent (Norway, Scotland, Spain and Central Europe), each with their own genetic characteristics that need to be preserved.....»»
International team decodes the genome of the Greenland shark
The Greenland Shark (Somniosus microcephalus), an elusive dweller of the depths of the northern Atlantic and the Arctic Ocean, is the world's longest-living vertebrate, with an estimated lifespan of about 400 years......»»
Researchers sequence the genome of the spur-thighed tortoise
Like many threatened land turtle species, the spur-thighed tortoise had no complete genome. Now for the first time, researchers from the Ecology departments at Miguel Hernández University of Elche (UMH) and the University of Alicante (UA) have succe.....»»
Novel quantum dot hydrogel shows improved photothermal conversion efficiency
Biomolecules-based materials hold great promise for malignant tumor phototherapy. However, current supramolecular biomaterials primarily suffer from poor tissue penetration, inadequate tumor accumulation, and particularly neglecting the unique benefi.....»»
Researchers bend DNA strands with light, revealing a new way to study the genome
With the flick of a light, researchers have found a way to rearrange life's basic tapestry, bending DNA strands back on themselves to reveal the material nature of the genome......»»
Experimental nanomedicine delivers chemo drugs directly to tumors in mice
Researchers at the University of Chicago Medicine Comprehensive Cancer Center have developed a nanomedicine that increases the penetration and accumulation of chemotherapy drugs in tumor tissues and effectively kills cancer cells in mice......»»
Could alternative meat meet a growing demand?
Inside a UC Davis engineering lab, tiny round pellets swirl in a brown liquid inside a 5-liter glass tank. The tank, a bioreactor, is brewing edible fungi high in protein and designed to look and taste like meat......»»