Unveiling the 3D structure and molecular mechanism of platelet drug transporter ABCC4
A research team led by Prof. Chen Yuxing and Prof. Zhou Cong from the University of Science and Technology of China (USTC) of the Chinese Academy of Sciences (CAS) recently utilized single-particle cryogenic electron microscopy (cryo-EM) to decipher.....»»
New data science tool greatly speeds up molecular analysis of our environment
A research team led by scientists at the University of California, Riverside, has developed a computational workflow for analyzing large data sets in the field of metabolomics, the study of small molecules found within cells, biofluids, tissues, and.....»»
AI for drug discovery: DrugSynthMC to make finding new medication more efficient
Scientists have devised a free AI algorithm that they believe will make finding new medicines far more efficient......»»
X-Ray Imaging and Spectroscopy Mission unveils black hole and supernova remnant surroundings
The X-Ray Imaging and Spectroscopy Mission (XRISM) has revealed the structure, motion and temperature of the material around a supermassive black hole and in a supernova remnant in unprecedented detail. Astronomers presented the first scientific resu.....»»
Researchers identify novel endocytic recycling mechanism with "kiss-and-run" membrane fusion
Endocytosis and recycling control the uptake and retrieval of various materials in eukaryotic cells. Mammalian cells have developed several recycling routes, including the relatively extensively studied "fast" and "slow" tubulovesicular recycling pat.....»»
How a bacterial pathogen that causes dysentery manipulates molecular activity to assure its survival
Virginia Tech researchers have learned how bacteria manipulate molecules to infect the host organism. Daniel Capelluto and his research team have discovered the mechanism by which the bacterial pathogen Shigella flexneri, the causative agent of dysen.....»»
Study shows cholesterol enhances exosome-mediated RNA drug delivery
RNA interference (RNAi) technology has gradually become a cutting-edge technology for treating diseases such as genetic disorders and cancer due to its huge potential in gene expression regulation. However, the efficient delivery and safety of short.....»»
Double-edged STING: A new pathway involved in aging
A protein called STING, previously shown to control a pathway that contributes to antiviral signaling, also plays an important role in cellular stress clearance and cell survival, according to a new paper published in Molecular Cell......»»
Researchers achieve aluminum molecular ring-based rotaxane and polyrotaxane
Rotaxanes have garnered interest for their unique structures consisting of mechanically interlocked axles and macrocycles. Numerous organic macrocycles have been employed to construct rotaxanes, including crown ether, cyclobis(paraquat-p-phenylene),.....»»
NASA"s Chandra finds galaxy cluster that crosses the streams
Astronomers using NASA's Chandra X-ray Observatory have found a galaxy cluster has two streams of superheated gas crossing one another. This result shows that crossing the streams may lead to the creation of new structure......»»
Simulated construction of plant-based fish meat with composite structure via 3D printing
To date, about 90% of fish resources worldwide have already reached their sustainable fishery limit. Meanwhile, intensive farming and aquaculture contribute to significant environmental pollution and degradation. To address both the challenges of lim.....»»
A drug made by a Florida company has been recalled for a possibly lethal contamination
A drug made by a Florida company has been recalled for a possibly lethal contamination.....»»
Was Thalidomide Safe? Frances Oldham Kelsey Was Not Convinced
In the U.S. in the early 1960s the distributor of a thalidomide drug was impatient to get it on the market. But FDA medical examiner Frances Oldham Kelsey wanted more information to prove its safety.....»»
Obesity-Drug Pioneers Win Prestigious Lasker Award for Medical Science
Three scientists are honored for developing a class of blockbuster weight-loss drugs. Is a Nobel prize on the way?.....»»
Homeopathic company refuses to recall life-threatening nasal spray, FDA says
Consumers should stop using SnoreStop, FDA says. Enlarge (credit: Getty | Florian Gaertner) The maker of a homeopathic nasal spray with a history of contamination is refusing to recall its product after the Food and Drug.....»»
Study suggests political ideology is associated with differences in brain structure, but less so than previously thought
Conservative voters have slightly larger amygdalas than progressive voters—by about the size of a sesame seed. In a replication study published September 19 in the journal iScience, researchers revisited the idea that progressive and conservative v.....»»
Researchers explore physiological and molecular processes underlying graft healing
Grafting has long been a cornerstone in agriculture and forestry, allowing for the propagation of desirable plant traits and improved resistance to environmental challenges. Despite its widespread application, grafting still encounters obstacles, inc.....»»
Decoding "Chachi" citrus: Unveiling the secrets of flavorful phytonutrients
Citrus reticulata "Chachi" (CRC), a staple in traditional medicine and modern pharmacology, is renowned for its rich flavonoid content, which underpins its health-promoting properties. Despite its widespread use, the biosynthetic pathways and genetic.....»»
New mechanism uncovered for the reduction of emu wings
.Researchers have uncovered a novel mechanism underlying the skeletal reduction and asymmetry of emu wings. Their research reveals that the absence of distal muscle formation results in a lack of mechanostress during development, leading to the obser.....»»
Bioengineers create new substrate to study wood-decomposing enzyme
Researchers want to transform the natural and abundant resource wood into useful materials, and central to that is a molecular machine found in fungi that decomposes the complex raw material into its basic components......»»
In morning raids in Erie, FBI makes arrests on drug, weapon charges. 24 defendants named
In morning raids in Erie, FBI makes arrests on drug, weapon charges. 24 defendants named.....»»