The One-Shot Drug That Keeps on Dosing
Chronic illness patients often struggle to keep up with medications that need frequent, timely doses. What if a single shot lasted for months?.....»»
Ancient Roman wine production may hold clues for battling climate change
It is no secret that the Romans were heavy wine drinkers. Estimates put the average Roman male's consumption at a liter or more of diluted wine per day. The drink was also a symbol of civilized behavior, and widely used as a drug, medicine and ritual.....»»
Big Pharma to raise US list prices of 500 drugs in January: Report
The hikes come as drug makers face new federal rules to try to drag down prices. Enlarge (credit: Getty | Bill Diodato) January is usually a big month for hiking the list prices of drugs in the US—and it looks like 202.....»»
Novel approach uses ionic liquids for diverse aptamer applications
Aptamers, nucleic acids capable of selectively binding to viruses, proteins, ions, small molecules, and various other targets, are garnering attention in drug development as potential antibody substitutes for their thermal and chemical stability as w.....»»
Greg Joswiak talks Steve Jobs keynotes, ‘Shot on iPhone’ event, and more in new interview [Video]
Greg Joswiak, Apple’s Senior Vice President of Worldwide Marketing, recently sat down with Thai outlet iMod for an interview. In the video posted on YouTube, Josiwak talks about Apple’s decision to shoot an entire event with an iPhone, how the co.....»»
Oral peptides: A new era in drug development
For decades, a substantial number of proteins, vital for treating various diseases, have remained elusive to oral drug therapy. Traditional small molecules often struggle to bind to proteins with flat surfaces or require specificity for particular pr.....»»
GPCR structure: Research reveals molecular origins of function for a key drug target
Through an international collaboration, scientists at St. Jude Children's Research Hospital have leveraged data science, pharmacology and structural information to conduct an atomic-level investigation into how each amino acid in the receptor that bi.....»»
Daily Telescope: A simple shot of the Milky Way high above France and Spain
"Both the daytime and nighttime vistas there were just bloody marvelous." Enlarge / The Milky Way Galaxy above the Pyrenees, right on the French and Spanish border. (credit: bulbs_01_frizzle) Welcome to the Daily Tel.....»»
Dogs, antennas and honey for Japan"s big bear problem
Thousands of bears are being shot in Japan each year as they become more and more of a problem. Junpei Tanaka and his dog Rela, straining at her leash in the woods, have a kinder, smarter way......»»
AI generates proteins with exceptional binding strengths
A new study in Nature reports an AI-driven advance in biotechnology with implications for drug development, disease detection, and environmental monitoring. Scientists at the Institute for Protein Design at the University of Washington School of Medi.....»»
New chemical method advances toward targeted RNA medicine
Targeted drugs aim to pinpoint the exact location in the body where diseased tissue is located and where the medicine is required. The manifold benefits of administering a targeted drug include heightened efficacy, as the drug is meticulously designe.....»»
Advances in nanoscale carrier-based approaches to enhance efficacy of podophyllotoxin
Podophyllotoxin (PPT), an aryltetralin-type lignan isolated from Podophyllum species, exhibits a wide range of biologic and pharmacologic activities, and mainly serves as an antiviral agent or antitumor drug in clinical applications......»»
Drug-resistant fungus is on the rise worldwide, says molecular biologist
The Candida auris fungus is spreading across the globe at an "alarming" speed. This species of fungus, which can cause fatal infections in risk groups and was first discovered only 10 years ago, can now be found all over the world. In nearly all case.....»»
Crystal language empowers AI to design novel materials with desired properties
Over the past decade, generative deep learning models have been applied successfully to the design of novel drug molecules, organic synthesis routes, and functional molecules tailored for electronic/optoelectronic devices. This is largely enabled by.....»»
Blue Origin sure seems confident it will launch New Glenn in 2024
Does Jeff Bezos's heavy-lift rocket really have a shot at launching next year? Enlarge / This picture, taken several months ago, shows different parts for Blue Origin's New Glenn rocket inside the company's manufacturing facility.....»»
Adapting cybersecurity for the quantum computing era
Researchers are exploring promising quantum computing applications across various domains, from cryptography and optimization problems to drug discovery and artificial intelligence. The race to harness the power of quantum bits has sparked a wave of.....»»
Catalyst makes drugs inside the body to minimize side effects
A highly active catalyst capable of synthesizing drug molecules within the body has been developed by RIKEN chemists. In mice, an anticancer drug assembled near tumors using the injected catalyst suppressed tumor growth......»»
Spinning up control: Propeller shape helps direct nanoparticles, researchers say
Self-propelled nanoparticles could potentially advance drug delivery and lab-on-a-chip systems—but they are prone to go rogue with random, directionless movements. Now, an international team of researchers has developed an approach to rein in the s.....»»
Novel insights into antibody aggregation expected to open up new avenues for research and therapeutic applications
Antibodies (immunoglobulins) are Y-shaped proteins that recognize and neutralize specific pathogens. Their ability to target specific molecules or cells has made them promising candidates for future drug development. However, their light chains—par.....»»
New approach to drug discovery: Developing pain medication with fewer side effects
People with chronic pain are often dependent on drugs from the class of opioids with sometimes considerable side effects. Accordingly, in recent years the search for safer alternatives has been the focus of new drug discovery......»»
A deep-learning framework for drug–drug interactions and drug–target interactions prediction
Exploring the biomedical interactions for chemical compounds and protein targets is crucial for drug discovery. Determining these drug–drug interactions (DDI) and drug–target interactions (DTI) not only reveals the potential synergistic effects o.....»»