Structure-destabilizing mutations transform Bcl-2 from an antiapoptotic protein into a proapoptotic protein
Bcl-2 family proteins are highly conserved molecules that play a crucial role in regulating the release of apoptotic proteins from mitochondria. They possess Bcl-2 homology (BH) domains, which are characterized by both sequence and structural similar.....»»
Researchers uncover key insights into cholesterol"s structure in cell membranes
A new study by Rice University researchers led by Jason Hafner could open new pathways for understanding how cholesterol influences cell membranes and their receptors, paving the way for future research on diseases linked to membrane organization. Th.....»»
Chemists discover new ways in which single-celled organisms organize their DNA
It has only recently been discovered that single-celled organisms (bacteria and archaea) also have histones—proteins that structure DNA. Now, Leiden Ph.D. candidate Samuel Schwab has found that the histones in these organisms are much more diverse.....»»
From chaos to order: Proteins can re-structure themselves to create important substances
The protein "MIPS" changes its internal structure when it becomes active. Its disordered active center becomes a defined structure with special functions. The protein plays a key role in the production of inositol, which is also known as vitamin B8,.....»»
New biosensor illuminates physiological signals in living animals
Eric Schreiter and Luke Lavis thought they had figured it out. In 2021, the Janelia group leaders reported that they had developed a way to combine Schreiter's engineered protein biosensors and Lavis's bright, fluorescent Janelia Fluor dyes......»»
New method developed to relocate misplaced proteins in cells
Cells are highly controlled spaces that rely on every protein being in the right place. Many diseases, including cancers and neurodegenerative disorders, are associated with misplaced proteins. In some cancers, for instance, a protein that normally s.....»»
X-Ray Imaging and Spectroscopy Mission unveils black hole and supernova remnant surroundings
The X-Ray Imaging and Spectroscopy Mission (XRISM) has revealed the structure, motion and temperature of the material around a supermassive black hole and in a supernova remnant in unprecedented detail. Astronomers presented the first scientific resu.....»»
Double-edged STING: A new pathway involved in aging
A protein called STING, previously shown to control a pathway that contributes to antiviral signaling, also plays an important role in cellular stress clearance and cell survival, according to a new paper published in Molecular Cell......»»
NASA"s Chandra finds galaxy cluster that crosses the streams
Astronomers using NASA's Chandra X-ray Observatory have found a galaxy cluster has two streams of superheated gas crossing one another. This result shows that crossing the streams may lead to the creation of new structure......»»
Simulated construction of plant-based fish meat with composite structure via 3D printing
To date, about 90% of fish resources worldwide have already reached their sustainable fishery limit. Meanwhile, intensive farming and aquaculture contribute to significant environmental pollution and degradation. To address both the challenges of lim.....»»
Study suggests political ideology is associated with differences in brain structure, but less so than previously thought
Conservative voters have slightly larger amygdalas than progressive voters—by about the size of a sesame seed. In a replication study published September 19 in the journal iScience, researchers revisited the idea that progressive and conservative v.....»»
Plant pathogen battle: A tomato protein"s dual role in defense and susceptibility
Tomatoes, a staple crop worldwide, are increasingly threatened by biotic stressors such as viruses, fungi, and bacteria, with the effects worsening under climate change. These challenges lead to reduced yields and compromised nutritional quality, hig.....»»
Bioengineers create new substrate to study wood-decomposing enzyme
Researchers want to transform the natural and abundant resource wood into useful materials, and central to that is a molecular machine found in fungi that decomposes the complex raw material into its basic components......»»
Physicists reveal evolution of shell structure using machine learning
A research team has used a machine learning approach to investigate the evolution of shell structure for nuclei far from the stability valley. The study, published in Physics Letters B and conducted by researchers from the Institute of Modern Physics.....»»
An unexpected protein connection in maize growth and defense could enhance crop resilience
Maize (corn) is one of the most important staple crops in the world and has been extensively studied. Yet, many aspects of the genetic mechanisms regulating its growth and development remain unexplored......»»
Team discovers naturally occurring DNA-protein hybrids
Thanks to a serendipitous discovery and a lot of painstaking work, scientists can now build biohybrid molecules that combine the homing powers of DNA with the broad functional repertoire of proteins—without having to synthesize them one by one, res.....»»
New method improves understanding of light-wave propagation in anisotropic materials
Understanding how light travels through various materials is essential for many fields, from medical imaging to manufacturing. However, due to their structure, materials often show directional differences in how they scatter light, known as anisotrop.....»»
‘Make a street for the future’: Plans underway to transform major corridor in Boston
‘Make a street for the future’: Plans underway to transform major corridor in Boston.....»»
Bridging large riverine ecosystems for inter-basin exchanges
Many of the world's large rivers have been modified to support food security, hydropower production, navigation and trade. While these developments are necessary to support a growing human population, they also pose substantial risks to the structure.....»»
Scientists discover how TGF-Beta sends its message even while tethered to the cell membrane
For years, scientists have thought that TGF-Beta, a signaling protein that holds sway over an astonishing array of cellular processes from embryonic development to cancer, could only do its work once it escaped a lasso-like "straitjacket.".....»»
Virtual laboratory allows scientists to simulate specific decreases in gene activity
Imagine you're looking at millions upon millions of mysterious genetic mutations. With CRISPR gene-editing technology, a select few of these mutations might have therapeutic potential. However, proving it would mean many thousands of hours of lab wor.....»»