RNA modification: Mechanisms and therapeutic targets
RNA modifications are dynamic and reversible chemical modifications on substrate RNA that regulate mRNA stability, translation, and localization. This review is designed by Dr. Junhong Han and written by his postdoctoral researcher Dr. Lei Qiu and P.....»»
Near-infrared photobiomodulation technique targets brain inflammation
As the world grapples with an aging population, the rise in neurodegenerative diseases such as Alzheimer's and Parkinson's is becoming a significant challenge. These conditions place a heavy burden not only on those afflicted but also on their famili.....»»
Dual action antibiotic could make bacterial resistance nearly impossible
A new antibiotic that works by disrupting two different cellular targets would make it 100 million times more difficult for bacteria to evolve resistance, according to new research from the University of Illinois Chicago......»»
Chemists develop test to track crucial edits to RNA
A research team's new technique could help scientists worldwide identify novel targets for cancer therapies......»»
Vulnerability in Telegram app for Android allows sending malicious files disguised as videos
ESET researchers discovered a zero-day exploit, which targets the Telegram app for Android, that appeared for sale for an unspecified price in an underground forum post from June 2024. Example of how the EvilVideo exploit appears on Telegram (source:.....»»
Smallholder farmers, efficient ranching practices critical to meet restoration targets in Brazil"s Atlantic Forest
A new study led by King's College London simulated the effects of various restoration policies to assess their impact on biodiversity and agricultural production......»»
Study deciphers intricate 3D structure of DNA aptamer for disease theranostics
In a study published in PNAS, a research team has resolved the first high-resolution structure of the sgc8c DNA aptamer that targets protein tyrosine kinase 7 (PTK7), engineered two optimal sgc8c variants for disease theranostics efficiently, and rev.....»»
New nanoparticle delivery method targets sickle cell mutations in bone marrow
Current gene therapies to treat sickle cell disease are complex, time-consuming, and are sometimes linked to serious side effects like infertility or blood cancer. To address these challenges, Johns Hopkins researchers have developed special nanopart.....»»
Genetic study reveals key to mulberry anthocyanin richness
Unlocking the genetic secrets of mulberry anthocyanin content, a study illuminates the regulatory mechanisms that dictate fruit color and nutritional quality. By assembling and analyzing the genomes of two distinct mulberry cultivars, researchers hav.....»»
Discovery of a tRNA modification enzyme that also acts on nucleosides
The genetic information on DNA is transcribed into messenger RNA (mRNA) and translated to the amino acid sequence by transfer RNA (tRNA) on the ribosome. Modified nucleosides within RNA are involved in maintaining and regulating the protein synthesis.....»»
Scientists uncover the molecular mechanism behind pineapple peel coloration
Pineapple peel coloration, especially the red hue, significantly enhances its commercial and aesthetic value. However, the genetic mechanisms driving this trait are not well understood, complicating breeding efforts for red-skinned varieties......»»
Harnessing big data helps scientists hone in on new antimicrobials
Researchers have developed a strategy to identify new antimicrobial drugs with therapeutic promise from bacterial datasets, providing clues for discovering alternatives to traditional antibiotics......»»
Void Banshee APT exploited “lingering Windows relic” in zero-day attacks
The zero-day exploit used to leverage CVE-2024-38112, a recently patched Windows MSHTML vulnerability, was wielded by an APT group dubbed Void Banshee to deliver malware to targets in North America, Europe, and Southeast Asia, threat hunters with Tre.....»»
Elon Musk signals delays to robotaxi unveiling for key design change
Musk had said in 2022 Tesla expects to mass-produce a robotaxi with no steering wheel or pedal by 2024, after missing his targets for self-driving vehicles multiple times......»»
Interdisciplinary approach provides new insights into molecular mechanisms of cholera infection
Cholera infections caused by Vibrio cholerae bacteria can be life-threatening and the trigger is the cholera toxin produced by the bacteria. It binds to the surface of intestinal cells—more precisely, to certain "sugar lipids" (GM1 gangliosides, GM.....»»
Researchers develop library for RNA-based therapeutic approaches with polymer nanoparticles
RNA therapy with polymer nanoparticles is considered a promising approach for the treatment of various illnesses. It involves the use of polymers as "nanocarriers" to transport RNA drugs precisely to the correct target cells. Manufacturing such polym.....»»
Understanding the role of RNA methylation in cancer
RNA modification could serve as a therapeutic target for certain types of cancer, according to a new study published in Molecular Cell, which sheds new light on the complex process underlying RNA transcription......»»
Four crucial climate targets the new UK government should adopt immediately
The UK is not on track to meet its climate targets and has no credible pathway to get there. However, a new set of more specific targets would provide some clarity for the country's new government and would ultimately help achieve the overall goal: p.....»»
Opening the right doors: New work reveals "jumping gene" control mechanisms
International joint research led by Akihisa Osakabe and Yoshimasa Takizawa of the University of Tokyo has clarified the molecular mechanisms in thale cresses (Arabidopsis thaliana) by which the DDM1 (Decreased in DNA Methylation 1) protein prevents t.....»»
Threat actors exploited Windows 0-day for more than a year before Microsoft fixed it
The goal of the exploits was to open Explorer and trick targets into running malicious code. Enlarge (credit: Getty Images) Threat actors carried out zero-day attacks that targeted Windows users with malware for more tha.....»»
Team investigates chemical modifications to gain deeper insights into genetic regulation mechanisms
University of North Carolina at Chapel Hill researchers have determined whether a specific chemical modification of a protein that packages the genome called a histone affects gene activity and cell proliferation, according to the paper, "Drosophila.....»»