Possible cause of male infertility linked to structural protein
Mature spermatozoa are characterized by a head, midpiece and a long tail for locomotion. Now, researchers from the University Hospital Bonn (UKB) and the Transdisciplinary Research Unit "Life & Health" at the University of Bonn have found that a loss.....»»
Scientists discover chemical probes for previously "undruggable" cancer target
Hormone-driven cancers, like those of the breast and prostate, often rely on a tricky-to-target protein called Forkhead box protein 1 (FOXA1). FOXA1 mutations can enable these types of cancers to grow and proliferate. Today, FOXA1 is notoriously diff.....»»
Cash transfers linked to improved educational outcomes for American Indian children
Research led by the University of California, Irvine has found that cash transferred to families significantly boosted academic performance among American Indian children......»»
Glowing proteins enable real-time, 3-D study of essential enzymes
Working in organoid models, researchers at University of California San Diego School of Medicine have developed a new tool to study protein-kinase C (PKC) enzymes, which play a critical role in cell growth, differentiation and survival. Malfunction o.....»»
Calcium transport protein in bacteria offers insights for drug development and food safety
Researchers at Umeå University have revealed details on how bacteria use calcium to regulate vital processes in a way that differs from human cells. This breakthrough is significant in the fight against antibiotic resistance and for increasing safet.....»»
Protein USP50 identified as key in DNA replication balance
A protein that is involved in determining which enzymes cut or unwind DNA during the replication process has been identified in a new study......»»
Expansion in situ genome sequencing innovation makes hidden DNA-protein interactions visible
Harvard scientists have unveiled a new technique called expansion in situ genome sequencing (ExIGS) that combines existing in situ genome sequencing (IGS) with expansion microscopy (ExM). The innovation allowed researchers to link nucleus abnormaliti.....»»
Machine learning cracked the protein-folding problem and won the 2024 Nobel Prize in chemistry
The 2024 Nobel Prize in chemistry recognized Demis Hassabis, John Jumper and David Baker for using machine learning to tackle one of biology's biggest challenges: predicting the 3D shape of proteins and designing them from scratch......»»
Targeting "undruggable" diseases: Researchers reveal new levels of detail in targeted protein degradation
Researchers at the University of Dundee have revealed in the greatest detail yet the workings of molecules called protein degraders which can be deployed to combat what have previously been regarded as "undruggable" diseases, including cancers and ne.....»»
Oxidative stress: How protein recycling protects against cell death
Researchers at LMU University Hospital have discovered a new molecular switch that protects against cell death......»»
Hidden in the teeth: DNA study finds these 19th century lions preyed on humans and giraffes
In 1898, two male lions terrorized an encampment of bridge builders on the Tsavo River in Kenya. The lions, which were massive and maneless, crept into the camp at night, raided the tents and dragged off their victims. The infamous Tsavo "man-eaters".....»»
Scientists discover how innate immunity envelops bacteria
The protein GBP1 is a vital component of our body's natural defense against pathogens. This substance fights against bacteria and parasites by enveloping them in a protein coat, but how the substance manages to do this has remained unknown until now......»»
High-resolution structural data shows how a supercomplex links mRNA translation and decay
Messenger RNA (mRNA) serves as a blueprint for proteins. When mRNA is no longer needed, it must be degraded. Director Elena Conti and her team at the Max Planck Institute of Biochemistry in Martinsried near Munich have now been able to show that the.....»»
AI-driven approach challenges traditional views on protein structure
In a recently published article in Nature Communications,, a team offers an AI-driven approach to explore structural similarities and relationships across the protein universe. The team includes members from the University of Virginia—including Phi.....»»
Male CEOs viewed positively for assertive activism stances, study reveals
Investors view CEOs more favorably when they respond to shareholder activism in ways that conform to gender stereotypes, according to new Cornell research......»»
Huge waves in the atmosphere dump extreme rain on northern Australia
In 2023, almost a year's worth of rain fell over ten days in parts of northwestern Australia, leading to catastrophic flooding in the town of Fitzroy Crossing and surrounds. The rainfall was linked to a tropical cyclone, but there were also lesser-kn.....»»
Detailed images of key protein complexes provide new insights into bacterial photosynthesis
Researchers at the University of Liverpool and collaborators have arrived at a new understanding of bacterial photosynthesis. Using novel techniques, investigators have unveiled intricate detailed images of the key photosynthetic protein complexes of.....»»
Review of English-language textbooks from 34 countries reveals persistent pattern of stereotypical gender roles
Gender biases around male and female roles and under-representation of female characters appeared in textbooks from around the world, with male-coded words appearing twice as often as female-coded words on average, according to a study published Octo.....»»
Protein structure and design software gets the Chemistry Nobel
One academic and two people from DeepMind take home the Nobel. On Wednesday, the Nobel Committee announced that it had awarded the Nobel Prize in chemistry to researchers who pion.....»»
Africa"s Great Green Wall will only combat desertification and poverty by harnessing local solutions, say researchers
In the rural village of Téssékéré, the increasing number and intensity of droughts linked to climate change is making the lives and livelihoods of the local Fulani communities increasingly vulnerable. Here, in the northern Sahel desert region of.....»»
VIP Automotive Group, Stellantis dealership face sexual harassment allegations in EEOC lawsuit
Male employees at the Hempstead, N.Y., dealership allegedly harassed female colleagues, creating a hostile work environment, according to the lawsuit......»»