New modified CRISPR protein can fit inside virus used for gene therapy
Researchers have developed a novel version of a key CRISPR gene-editing protein that shows efficient editing activity and is small enough to be packaged within a non-pathogenic virus that can deliver it to target cells. Hongjian Wang and colleagues a.....»»
New method achieves functional protein delivery into living cells
In cooperation with researchers from the China University of Petroleum, the working group of Dr. Werner Nau, Professor of Chemistry at Constructor University, has demonstrated the effectiveness of a new method of intracellular protein transport......»»
When ribosomes go rogue
Unusual variations in the cellular protein factory can skew development, help cancer spread, and more. But ribosome variety may also play biological roles, scientists say. In the.....»»
"True hybrid" mice might reveal how new species emerge
Forty years ago, a postdoctoral researcher named James McGrath who would go on to spend more than three decades as a clinical geneticist and research scientist at Yale, made a discovery that advanced scientists' understanding of gene control and the.....»»
Understanding the influence of specific gene mutations on starch properties in barley
Cereals such as rice, wheat, maize, and barley are essential in the human diet and have various uses in the food industry. Their suitability for different industrial applications depends on the properties of their grains. The major component of these.....»»
Drug delivery system overcomes circulatory roadblock that prevents gene therapies from reaching their targets
Exploiting the remarkable capability of viruses to transport gene therapies past what until now has been a circulatory roadblock is at the heart of a University of Alberta-led discovery that promises to re-energize the field of genetic medicine......»»
An elegant switch regulates production of protein variants during cell division
Our cells contain thousands of proteins that have gone largely undetected and unstudied until recent years: these are variants of known proteins, which cells can make when their protein-building machinery interacts differently with the same stretch o.....»»
Enhancing recombinant protein expression in lettuce
Recombinant proteins are crucial in pharmaceutical and other industries. A production method uses plants as hosts in transient protein expression systems. Researchers at the University of Tsukuba developed a technique to increase recombinant protein.....»»
Structural biology analysis of a Pseudomonas bacterial virus reveals a genome ejection motor
The viruses that infect bacteria are the most abundant biological entities on the planet. For example, a recent simple study of 92 showerheads and 36 toothbrushes from American bathrooms found more than 600 types of bacterial viruses, commonly called.....»»
Scientists uncover how transcription drives motion within the genome
A team of scientists has discovered surprising connections among gene activity, genome packing, and genome-wide motions, revealing aspects of the genome's organization that directly affect gene regulation and expression......»»
The best computer desks for 2024
Looking for a new piece of furniture that will fit in your office, dorm, or gaming cave? Here's a list of the top desks to fit all kinds of spaces and angles......»»
Sony LinkBuds Fit review: comfort above everything else
Sony's new earbuds offer amazing comfort, great sound, and a wealth of fun new features, including voice commands......»»
Researchers to explore light and ultrasound therapy for melanoma treatment in pigs
Texas A&M University researchers are collaborating on a new project that studies how ultrasound and light can treat melanomas in pigs......»»
The legendary Lego Hulkbuster is 30% off today
This Lego set is so big it can fit another Lego set inside of it. Now its 30% off......»»
Single-molecule imaging reveals aberrant DNA-binding dynamics of cancer-linked chromatin remodelers
Biophysical chemists from the National University of Singapore (NUS) have uncovered a previously hidden landscape that governs the intracellular organization and dynamics of SWI/SNF chromatin remodelers, an important class of protein complexes that c.....»»
Researchers find new role for protein in combating age-related diseases
McMaster University researchers have discovered a previously unknown cell-protecting function of a protein, which could open new avenues for treating age-related diseases and lead to healthier aging overall......»»
Discovery of key protein for biosynthesis of plant defense steroids could enhance pest control strategies
Researchers at the Max Planck Institute for Chemical Ecology have identified GAME15 as a key protein that regulates the biosynthesis of both steroidal glycoalkaloids and steroidal saponins in plants of the genus Solanum......»»
DNA-binding C2H2 zinc finger proteins also regulate RNA processing, researchers discover
Researchers at the University of Toronto have shown that an important class of DNA-binding factors can also bind to RNA, regulating gene expression through various mechanisms. The study significantly expands our understanding of these proteins' funct.....»»
Plant fungus provides new drug target for colorectal cancer therapy
Novel chemical compounds from a fungus could provide new perspectives for treating colorectal cancer, one of the most common and deadliest cancers worldwide......»»
Pathogenic system found on Providencia rustigianii has virulence gene akin to Salmonella"s
Salmonella and E. coli are well-known bacteria that cause food poisoning, but less understood are species of Providencia, another causative agent of serious symptoms......»»
Protein signaling pathway provides insights into cell migration and cancer metastasis
The innate immune response is the body's first line of defense against infection, and a successful immune defense takes a village: a combination of physical barriers, chemical attacks, and an army of specialized white blood cells. But maintaining and.....»»