Molecular mechanism of ZDHHC18-mediated palmitoylation of cGAS in innate immunity inhibition
Cyclic GMP-AMP synthase (cGAS), a double-stranded DNA (dsDNA) sensing protein, plays an important role in the strong innate immune response induced by pathogen derived nucleic acids......»»
Examining the genesis of CRISPR"s molecular scissors
Genome engineering may be the future of medicine, but it relies on evolutionary advances made billions of years ago in primordial bacteria, the original masters of gene editing......»»
Study reveals how marine bacteria combat algae
Algae and bacteria are inseparable in ocean ecosystems, with bacteria playing a crucial role in regulating the growth and metabolism of algae. In addition to mutualism, bacteria have developed various molecular-based strategies to combat algae......»»
Chemists used machine learning and molecular modeling to identify potential anticancer drugs
RUDN University chemists and colleagues from China built several machine learning models and discovered a group of potential drugs that inhibit the enzyme responsible for uncontrolled cell division. The results were published in Biomedicines......»»
Successful optical biosensing using dual optical combs: High sensitivity and rapid detection of biomolecules
Bio-sensors are biomolecular sensors that leverage or mimic the sophisticated molecular recognition capabilities of living organisms. They find widespread applications in fields such as health care, food, and the environment......»»
Stacking order and strain boosts second-harmonic generation with 2D Janus hetero-bilayers
A group of researchers from Tohoku University, Massachusetts Institute of Technology (MIT), Rice University, Hanoi University of Science and Technology, Zhejiang University, and Oak Ridge National Laboratory have proposed a new mechanism to enhance s.....»»
Iron-based molecular switch improves reaction yield by modulating zeolite catalyst acidity
A molecular switch, or molecule that changes in response to varying environmental stimuli, has successfully modified the acidity of a zeolite catalyst to improve the yield of paraxylene from methanol in heterogeneous catalysis, or a reaction where th.....»»
New pathway of diatom-mediated calcification and its impact on the biological pump
A research team found that the photosynthesis of Skeletonema costatum (S. costatum), a common diatom species, can induce substantial aragonite precipitation from artificial/natural seawater under significantly lower supersaturation levels required fo.....»»
Naming and shaming can be effective to get countries to act on climate, study shows
Enforcement is one of the biggest challenges to international cooperation on mitigating climate change in the Paris Agreement. The agreement has no formal enforcement mechanism; instead, it is designed to be transparent so countries that fail to meet.....»»
iPhone 15 boxes have new security mechanism to prove authenticity
There are a lot of scams out there involving Apple products, and it’s no different with the iPhone. This year, with the iPhone 15, Apple seems to have implemented a new security mechanism based on UV light to prove the authenticity of the device an.....»»
Researchers reveal composition and regulatory mechanism of the nucleolar vacuole in C. elegans
A team led by Prof. Guang Shouhong and Prof. Feng Xuezhu from the University of Science and Technology (USTC) of the Chinese Academy of Sciences (CAS) revealed, for the first time, the composition and regulatory mechanism of the nuclear vacuole in C......»»
Profiling artemisinin"s antimalarial mechanism: Research team reveals crucial target proteins
Jigang Wang and colleagues have made significant progress in unraveling the antimalarial mechanisms of artemisinin (ART) and its derivatives. Their latest research, published in the journal Engineering, sheds light on the crucial target proteins and.....»»
Team resolves molecular switching behavior of azonium compounds for light-controlled drugs
Molecules that change shape under the influence of light can be used as switches in biomedical applications, for instance to inhibit an enzyme. An international team of researchers, including chemists at the Universities of Amsterdam and Groningen, h.....»»
Scientists design fresh tomatoes suitable for mechanical harvesting
According to a study published in Nature Plants, Chinese scientists have elucidated the mechanism of fruit shape formation in tomatoes and have developed fresh tomatoes for mechanical harvesting......»»
Scientists reveal intricate mechanisms cells use to build protein destruction signals
Within the intricate molecular landscape inside of a cell, the orchestration of proteins demands precise control to avoid disease. While some proteins must be synthesized at specific times, others require timely breakdown and recycling. Protein degra.....»»
Scientists unravel the chemical mechanism behind silica-coated nanodiamonds
Coating something rare—tiny shards of diamond—with the main ingredient in sand might sound unusual, but the end result turns out to have a number of valuable applications. The trick is, nobody knows for sure how the two materials bond......»»
How bats evolved to avoid cancer
A new paper titled "Long-read sequencing reveals rapid evolution of immunity and cancer-related genes in bats" in Genome Biology and Evolution shows that rapid evolution in bats may account for the animals' extraordinary ability to both host and surv.....»»
New research unveils Pseudomonas cyclic lipopeptide medpeptin"s role in modulating plant immunity
A research study conducted by Hai-Lei Wei's research team at the Chinese Academy of Agricultural Sciences in China has revealed significant insights into the biosynthesis and modulation of plant immunity by a novel cyclic lipopeptide called medpeptin.....»»
Molecular properties are only weakly correlated, study finds
The number of molecules thought to exist is unfathomably large—somewhere between 1050 and 1060 (for comparison, there are only 1022 to 1024 stars in the observable universe). The chemical and pharmaceutical sciences have sought a comprehensive unde.....»»
Zero-waste synthesis of new supramolecular materials with remarkable mechanical properties
Researchers from Japan have unlocked the potential of tannic acid and ultra-high molecular weight polyethylene oxide by using them to synthesize strong and smart supramolecular gels in a zero-waste process. These gels exhibit remarkable characteristi.....»»
Novel approach to engineered cells may enable molecular medical imaging
A tiny molecular structure that looks like a bubble may be able to significantly improve medical imaging, according to a Penn State research team. Called gas vesicles (GVs), these structures are naturally produced by certain microorganisms and are re.....»»