Molecular "hub" regulates gene-silencing proteins
To keep their vital functions in balance, many organisms use small snippets of RNA to "silence" messenger RNAs that code for certain proteins. New research from FMI scientists has revealed a molecular hub that integrates the activities of different p.....»»
Study identifies compounds that extend longevity of Japanese morning glory flowers
The longevity of plant flowers is controlled by genetically programmed mechanisms. After a certain amount of time after flowering, the expression of genes associated with programmed cell death is induced and cellular components such as proteins and n.....»»
Ancient protein structure may have enabled early molecular evolution and diversification
In a finding that offers fresh insights into the early evolution of life on Earth, two RIKEN biologists have conducted lab experiments that have revealed a previously unknown protein fold, which is completely absent in modern proteins......»»
Filament structure found to activate and regulate CRISPR-Cas "protein scissors"
CRISPR-Cas systems help to protect bacteria from viruses. Several different types of CRISPR-Cas defense systems are found in bacteria, which differ in their composition and functions. Among them, the most studied proteins today are Cas9 and Cas12, al.....»»
LEGO-inspired RNA sensors enable customizable gene control
A research team has developed an RNA-based sensor platform that can regulate gene expression in bacteria. Their findings were recently featured in the journal Advanced Science......»»
Developing novel chiral capsule tools for advanced optical technologies
Chirality is an essential property in biology; the molecular building blocks of some of the most important biological structures, including DNA and proteins, are chiral. When a molecule is said to be chiral, it means that it is distinguishable from i.....»»
New method quantifies single-cell data"s risk of private information leakage
Access to publicly available human single-cell gene expression datasets, or scRNA-seq datasets, has significantly enhanced researchers' understanding of both complex biological systems and the etymology of various diseases. However, the increase in a.....»»
Planning a drug"s route in the body with synthetic chemistry
Researchers at the RIKEN Cluster for Pioneering Research (CPR) have developed technology that can alter, within the body, the recognized identity of proteins......»»
Research provides new insights into role of mechanical forces in gene expression
The genome inside each of our cells is modeled by tension and torsion—due in part to the activity of proteins that compact, loop, wrap and untwist DNA—but scientists know little about how those forces affect the transcription of genes......»»
Seeing double: Designing drugs that target "twin" cancer proteins
Some proteins in the human body are easy to block with a drug; they have an obvious spot in their structure where a drug can fit, like a key in a lock. But other proteins are more difficult to target, with no clear drug-binding sites......»»
3D structure of key protein could advance development of hormone-free male contraceptive pill
Melbourne-based scientists behind the development of a hormone-free, reversible male contraceptive pill have, for the first time, solved the molecular structure of the discovery program's primary therapeutic target, significantly increasing the chanc.....»»
Researchers witness nanoscale water formation in real time
For the first time ever, researchers have witnessed—in real time and at the molecular-scale—hydrogen and oxygen atoms merge to form tiny, nano-sized bubbles of water......»»
DNA technology enables molecular monitoring for marine change and threats
New DNA technology promises to improve efforts to monitor marine life in the Southern Ocean, and detect the presence of non-native marine species close to Antarctica......»»
Molecular computing method uses metal ions to mimic complex mathematical functions
Researchers at the University of Twente have developed a new method that allows them to precisely control chemical reactions using metal ions. This marks an important step toward computers that function like the human brain. They recently published t.....»»
Exploring the role of hydrogen sulfide in the expression of iron uptake genes in E. coli
Antibiotic resistance and oxidative stress response are important biological mechanisms that help bacteria thrive, especially pathogenic bacteria like Escherichia coli. Hydrogen sulfide (H2S), a chemical messenger molecule, regulates several intracel.....»»
How a protein keeps gene clusters quiet in the cell nucleolus
In a discovery that sheds light on the complex mechanisms of gene regulation, scientists at EPFL have uncovered a critical role for the protein ZNF274 in keeping certain gene clusters turned off by anchoring them to the cell nucleolus. The study is p.....»»
How iron and metabolic constraints can aid gene discovery for photosynthesis and biofuel production
The single-cell green alga Chromochloris zofingiensis is an emerging model organism for photosynthesis and metabolism research. Previous research has shown that with the addition of glucose, Chromochloris zofingiensis shuts off photosynthesis, rerout.....»»
Scientists identify structural basis of stitched-together protein complexes that recycle most proteins in cells
Scientists at Sanford Burnham Prebys have developed a clearer picture of how crucial machinery in the human cell's recycling process for obsolete and misshapen proteins—known as proteasomes—are formed......»»
AI trained on evolution"s playbook develops proteins that spur drug and scientific discovery
A new artificial intelligence model developed by researchers at The University of Texas at Austin paves the way for more effective and less toxic treatments and new preventive strategies in medicine. The AI model informs the design of protein-based t.....»»
Biologists sequence proteins by pulling them through nanopores
A team of chemical biologists at the University of Washington, working with colleagues at Oxford Nanopore Technologies, has developed a protein sequencing process that involves pulling proteins through nanopores in a lipid membrane. Their paper is pu.....»»
Researcher develops low-sugar ice cream with smooth texture
Wageningen researcher Qi Wang has developed a new variant of low-sugar ice cream that mimics the texture and melting properties of traditional ice cream. By replacing half of the sugar with broken-down proteins or the sweetener xylitol, she succeeded.....»»