Identifying individual proteins using nanopores and supercomputers
The amount and types of proteins our cells produce tell us important details about our health. Researchers have shown that it is possible to identify individual proteins with single-amino acid resolution and nearly 100% accuracy. Their method uses na.....»»
Nobel Prize in chemistry awarded for work on proteins
The Nobel Prize in chemistry was awarded Wednesday to scientists David Baker, Demis Hassabis and John Jumper for their work with proteins......»»
Nanopore technique shows transport mechanism of chaperone proteins at the single-molecule level
Proteins control most of the body's functions, and their malfunction can have severe consequences, such as neurodegenerative diseases or cancer. Therefore, cells have mechanisms in place to control protein quality......»»
Comprehensive efforts needed to develop health-promoting learning environments, review finds
Mental ill-health among students in higher education is a growing problem globally. Most efforts implemented to address ill-health involve individual treatment and adjustments to pedagogy. But more can and needs to be done at a structural or environm.....»»
AI and quantum mechanics team up to accelerate drug discovery
Drug discovery is much like working a jigsaw puzzle. The chemical compounds behind drug molecules must be shaped to fit with the proteins in our bodies to produce therapeutic effects. That requirement for a meticulous fit means the creation of new dr.....»»
Study identifies compounds that extend longevity of Japanese morning glory flowers
The longevity of plant flowers is controlled by genetically programmed mechanisms. After a certain amount of time after flowering, the expression of genes associated with programmed cell death is induced and cellular components such as proteins and n.....»»
Unique IDs for individual (digital) specimens from natural history museums streamline and future-proof science
The wealth of data hosted in natural history collections can contribute to finding a response to global challenges ranging from climate change to biodiversity loss to pandemics. However, today's practices of working with collected bio- and geodiversi.....»»
"Tough and uncompromising" training capable of transforming social work culture
Described as "tough and uncompromising", Grit Breakthrough Programs uses intensive group workshops and individual coaching to challenge assumptions, attitudes, and expectations, with the aim of helping participants break through self-imposed limitati.....»»
Ancient protein structure may have enabled early molecular evolution and diversification
In a finding that offers fresh insights into the early evolution of life on Earth, two RIKEN biologists have conducted lab experiments that have revealed a previously unknown protein fold, which is completely absent in modern proteins......»»
Filament structure found to activate and regulate CRISPR-Cas "protein scissors"
CRISPR-Cas systems help to protect bacteria from viruses. Several different types of CRISPR-Cas defense systems are found in bacteria, which differ in their composition and functions. Among them, the most studied proteins today are Cas9 and Cas12, al.....»»
New triple star system sets shortest orbital period record
Professional and amateur astronomers have made a groundbreaking discovery with the help of artificial intelligence, identifying a unique triple star system named TIC 290061484. This stellar trio was uncovered through cosmic "strobe lights" observed b.....»»
Beyond "one pore at a time": New method of generating multiple, tunable nanopores
Nanoporous membranes with atomic-scale holes smaller than one-billionth of a meter have powerful potential for decontaminating polluted water, pulling valuable metal ions from the water, or for osmotic power generators......»»
Developing novel chiral capsule tools for advanced optical technologies
Chirality is an essential property in biology; the molecular building blocks of some of the most important biological structures, including DNA and proteins, are chiral. When a molecule is said to be chiral, it means that it is distinguishable from i.....»»
Planning a drug"s route in the body with synthetic chemistry
Researchers at the RIKEN Cluster for Pioneering Research (CPR) have developed technology that can alter, within the body, the recognized identity of proteins......»»
Research provides new insights into role of mechanical forces in gene expression
The genome inside each of our cells is modeled by tension and torsion—due in part to the activity of proteins that compact, loop, wrap and untwist DNA—but scientists know little about how those forces affect the transcription of genes......»»
Seeing double: Designing drugs that target "twin" cancer proteins
Some proteins in the human body are easy to block with a drug; they have an obvious spot in their structure where a drug can fit, like a key in a lock. But other proteins are more difficult to target, with no clear drug-binding sites......»»
Police seek help identifying 4 people in Boston assault that caused serious injuries
Police seek help identifying 4 people in Boston assault that caused serious injuries.....»»
AI bots now beat 100% of those traffic-image CAPTCHAs
I, for one, welcome our traffic light-identifying overlords. Enlarge / Examples of the kind of CAPTCHAs that image-recognition bots can now get past 100 percent of the time. (credit: Arxiv, Plesner et al.) Anyone who has.....»»
Scientists identify structural basis of stitched-together protein complexes that recycle most proteins in cells
Scientists at Sanford Burnham Prebys have developed a clearer picture of how crucial machinery in the human cell's recycling process for obsolete and misshapen proteins—known as proteasomes—are formed......»»
AI trained on evolution"s playbook develops proteins that spur drug and scientific discovery
A new artificial intelligence model developed by researchers at The University of Texas at Austin paves the way for more effective and less toxic treatments and new preventive strategies in medicine. The AI model informs the design of protein-based t.....»»
Biologists sequence proteins by pulling them through nanopores
A team of chemical biologists at the University of Washington, working with colleagues at Oxford Nanopore Technologies, has developed a protein sequencing process that involves pulling proteins through nanopores in a lipid membrane. Their paper is pu.....»»