How promiscuous protein droplets regulate immune genes
Biochemists at Emory are achieving insights into how an important regulator of the immune system switches its function, based on its orientation and local environment. New research demonstrates that the glucocorticoid receptor (or GR) forms droplets.....»»
Researchers examine protein arrangement in cell membrane that triggers programmed cell death
How can molecular structures be analyzed when the resolution of the techniques available is not sufficient? Researchers from the fields of physics, chemistry and medicine at Heinrich Heine University Düsseldorf (HHU) have combined and further develo.....»»
Glitch in protein synthesis could affect tumor growth
During protein synthesis, or translation, genetic information transcribed in the cell's mRNA directs the stringing together of amino acids—the building blocks of proteins. As the translation machinery carouses along the string of nucleotides that m.....»»
How context-specific factors control gene activity
Every cell in our body contains the same DNA, yet liver cells are different from brain cells, and skin cells differ from muscle cells. What determines these differences? It all comes down to gene regulation; essentially how and when genes are turned.....»»
Solving the side effect problem of siRNA drugs for genetic disease treatment
Small interfering RNA (siRNA) drugs are a class of therapeutic agents that silence specific genes associated with inherited diseases. However, siRNA drugs have challenges because siRNAs often silence genes other than the target ones, causing side eff.....»»
Angiosperms study provides insights into genome evolution after whole-genome duplications
Whole-genome duplication (WGD, or polyploidy) is a common and frequent occurrence in plants, providing raw genetic material for evolution. Homoeologs (duplicate genes from a WGD) often diverge in expression levels, while some still maintain similar (.....»»
Algorithm maps protein degradation patterns to improve infection diagnosis and treatment
Peptides are small fragments of proteins, mainly found in the skin and mucous membranes. Some peptides act as a barrier, protecting the body against infections by fighting off microorganisms like bacteria, viruses, and other pathogens, while others p.....»»
Regulatory gene influences shape recognition in medaka fish, scientists discover
Medaka fish that lack functional Hmgn2 genes are unable to distinguish between simple shapes, revealing a new function for the regulatory gene......»»
Bioengineers develop protein assembly road map for nature-derived nanobubbles
As far as water gear goes, floaties are not exactly high tech. But the tiny air-filled bubbles some microorganisms use as flotation devices when they compete for light on the water surface are a different story......»»
Breaking boundaries: PAM-less genome editing in soybean
CRISPR-Cas9 has transformed crop genetic improvement, yet its reliance on specific protospacer adjacent motif (PAM), sequences limits editing scope and efficiency. In soybean, a critical source of protein and oil, these limitations hinder the develop.....»»
Twenty-six states may soon need to regulate cannabis—here"s what they can learn from Colorado and Washington
The U.S. Drug Enforcement Administration has made moves to reclassify marijuana, making it a type of legal but regulated medicine, like Tylenol with codeine or some steroids......»»
3D bioprinting materials offer possibility for better bone and soft tissue repair
3D bioprinting is an advanced tissue engineering technique that builds complex tissues using bioactive substances like living cells and scaffolds. It provides personalized tissue repair solutions, reducing immune rejection by using patient-specific c.....»»
Cells use alternative splicing to regulate gene expression, research suggests
Alternative splicing is a genetic process where different segments of genes are removed, and the remaining pieces are joined together during transcription to messenger RNA (mRNA). This mechanism increases the diversity of proteins that can be generat.....»»
Investigation reveals global fisheries are in far worse shape than we thought—and many have already collapsed
When fish are taken from our oceans faster than they can reproduce, their population numbers decline. This over-fishing upsets marine ecosystems. It's also bad for human populations that rely on fish for protein in their diets......»»
Researchers identify genes for low glycemic index and high protein in rice
A team of researchers at the International Rice Research Institute (IRRI) has identified genes and markers responsible for low glycemic index (GI) and high protein content in rice, using genetics and artificial intelligence classification methods......»»
Scientists unlock the secrets of how a key protein converts DNA into RNA
Researchers at the Department of Energy's SLAC National Accelerator Laboratory have uncovered new insights into the fundamental mechanisms of RNA polymerase II (Pol II), the protein responsible for transcribing DNA into RNA. Their study shows how the.....»»
A chloroplast-mimicking nanoreactor for enhanced CO₂ electrocatalysis
Chloroplast, which is a double-membrane-bounded organelle, is the main site for CO2 fixation via photosynthesis in green plants. The double-membrane configuration can regulate the transport of substances into and out of the chloroplasts with the aid.....»»
Protein mutant stability can be inferred from AI-predicted structures
Researchers at the Center for Algorithmic and Robotized Synthesis within the Institute for Basic Science have taken a significant step forward in understanding the stability of proteins by leveraging the power of AI......»»
Arctic heat waves linked to sea ice loss, new study reveals
Amid global warming, heat waves are striking even the Arctic, a region once considered immune to such extreme weather events. Recent research reveals that these heat waves, particularly in the Barents-Kara Sea (BKS) during the boreal autumn, are not.....»»
Study shows an electrically-activated protein regulates spermatogenesis
Frankenstein's monster was brought to life by the judicious application of a little electricity; and a surprising number of processes in our bodies are regulated by electrical currents too. Now, researchers from Japan reveal that electricity may play.....»»
Using metal ion-linked nanostructures to improve immune response and boost breast tumor treatment
Immune checkpoint blockade (ICB) is one of the primary methods of tumor immunotherapy. However, clinical data have shown that only a portion of patients respond to ICB treatment. Since the tumor's immune-suppressive environment plays a crucial role i.....»»