Fluorescent visualization and evaluation of NPC1L1-mediated cholesterol absorption at the levels of endocytic vesicles
Excessive cholesterol absorption from intestinal lumen contributes to the pathogenesis of hypercholesterolemia, which is a well-established risk factor for atherosclerotic cardiovascular disease. The absorption of intestinal cholesterol is primarily.....»»
UN chief says sea level rise threatens "rising tide of misery"
United Nations Secretary-General Antonio Guterres warned on Wednesday that rising sea levels threaten to create "a rising tide of misery" for millions, with intense storm surges, coastal erosion and coastal flooding increasingly likely......»»
Violence, harassment from students is overwhelmingly "part of the job" for Saskatchewan education sector workers
Saskatchewan education sector workers are experiencing disturbing levels of workplace violence and harassment, says a new report spotlighting a situation that has reached "a breaking point," according to its authors......»»
Discovering new energy levels in atomic hyperfine structures
Since the late 1960s, the Laboratoire Aimé Cotton (LAC) in Orsay, France, has made significant progress in the classification of complex atomic spectra. These advances have been driven both by the development of Fourier transform spectroscopy, and t.....»»
Researchers uncover key insights into cholesterol"s structure in cell membranes
A new study by Rice University researchers led by Jason Hafner could open new pathways for understanding how cholesterol influences cell membranes and their receptors, paving the way for future research on diseases linked to membrane organization. Th.....»»
Compact "gene scissors" enable effective genome editing, may offer future treatment of high cholesterol gene defect
CRISPR-Cas is used broadly in research and medicine to edit, insert, delete or regulate genes in organisms. TnpB is an ancestor of this well-known "gene scissors" but is much smaller and thus easier to transport into cells......»»
Study reveals high rates of seafood mislabeling and ambiguous market names in Calgary, Alberta
A study published in PeerJ Life and Environment has uncovered alarming levels of seafood mislabeling and the use of ambiguous market names in Calgary's seafood market, often concealing species of conservation concern. This research marks the first Ca.....»»
New biosensor illuminates physiological signals in living animals
Eric Schreiter and Luke Lavis thought they had figured it out. In 2021, the Janelia group leaders reported that they had developed a way to combine Schreiter's engineered protein biosensors and Lavis's bright, fluorescent Janelia Fluor dyes......»»
Researchers identify novel endocytic recycling mechanism with "kiss-and-run" membrane fusion
Endocytosis and recycling control the uptake and retrieval of various materials in eukaryotic cells. Mammalian cells have developed several recycling routes, including the relatively extensively studied "fast" and "slow" tubulovesicular recycling pat.....»»
Study shows cholesterol enhances exosome-mediated RNA drug delivery
RNA interference (RNAi) technology has gradually become a cutting-edge technology for treating diseases such as genetic disorders and cancer due to its huge potential in gene expression regulation. However, the efficient delivery and safety of short.....»»
Moderate levels of exotic species invasions may help maintain biodiversity, study suggests
Globally, more than 13,000 plant species, equivalent to the entire native flora of Europe, have been naturalized outside their native ranges. A study, jointly conducted by scientists from China and the U.S., provides new insights about biodiversity,.....»»
New research re-envisions Earth"s mantle as a relatively uniform reservoir
Lavas from hotspots—whether erupting in Hawaii, Samoa or Iceland—likely originate from a worldwide, uniform reservoir in Earth's mantle, according to an evaluation of volcanic hotspots published in Nature Geoscience......»»
DNA origami and fluorescent probes can precisely release molecular cargo
In the world of nanotechnology, the development of dynamic systems that respond to molecular signals is becoming increasingly important. The DNA origami technique, whereby DNA is programmed so as to produce functional nanostructures, plays a key role.....»»
Will customers accept less meat in their cafeteria meals?
Meat consumption in industrial nations is much too high and this not only increases the risk of e.g. cardiovascular diseases. Increasing levels of animal husbandry also aggravate the global food problem because the cultivation of animal feed uses val.....»»
‘I’m a Cardiologist, and This Is the #1 Most Important Thing To Do if You Know You’re at Risk for High Cholesterol"
‘I’m a Cardiologist, and This Is the #1 Most Important Thing To Do if You Know You’re at Risk for High Cholesterol".....»»
Antarctic krill can lock away similar levels of carbon as seagrass and mangroves, finds study
Small marine crustaceans are as valuable as key coastal habitats for storing carbon and should be similarly protected, according to new research......»»
Widgetsmith updated for iOS 18 with aesthetic new ‘Actions’ system
Widgetsmith, everyone’s favorite aesthetic app, is getting a big update today to take advantage of iOS 18. As detailed in a blog post, Widgetsmith 7 “takes device customization to all-new levels.” The update focuses on new customizable Actions.....»»
Road networks stretch into Congo Basin forests: Satellites and AI help to monitor
The Congo Basin rainforest is the second-largest tropical forest in the world, storing large volumes of carbon and hosting high levels of biodiversity. While these forests have historically stayed mostly intact, road development has recently become a.....»»
The air quality in Big Bear suddenly reached hazardous levels this week: What happened?
Plumes of smoke from Southern California's fires blew across Big Bear on Sept. 11, causing local air quality meters to return off-the-chart readings for particulate pollution......»»
New strategy for simulating nonadiabatic dynamics of molecules at metal surfaces
A research team has proposed a novel approach to accurately describe electron transfer mediated nonadiabatic dynamics of molecules at metal surfaces. Their works were published in Physical Review Letters......»»
Exploring ternary metal sulfides as electrocatalysts for carbon dioxide reduction reactions
One of the most promising avenues for actively reducing CO2 levels in the atmosphere is recycling it into valuable chemicals via electrocatalytic CO2 reduction reactions. With a suitable electrocatalyst, this can be achieved under mild conditions and.....»»