Everything You Need to Know About Getting Your Genome Sequenced
DNA sequencing can assess your risk of developing certain diseases. It could even help provide medicines personalized to your genes one day. Governments want you to get involved......»»
A More Elegant Form of Gene Editing Progresses to Human Testing
Instead of cutting out chunks of the genome to disable malfunctioning genes, base editing makes a smaller, more precise swap......»»
Lost puzzle piece involved in gene regulation revealed in search that began in water-loving, one-celled organism
After an intrepid, decade-long search, Johns Hopkins Medicine scientists say they have found a new role for a pair of enzymes that regulate genome function and, when missing or mutated, are linked to diseases such as brain tumors, blood cancers and K.....»»
Documentary spurs a new look at the case of the first gene-edited babies
In the four years since an experiment by disgraced scientist He Jiankui resulted in the birth of the first babies with edited genes, numerous articles, books and international commissions have reflected on whether and how heritable genome editing—t.....»»
3D structure of mammalian genome reveals record-breaking diversity
The genome (the code of life) is organized in the form of folded chromosomes within the nucleus of cells. This three-dimensional organization of the genome is fundamental, as it determines which genes are switched on and off in each cell type. Compar.....»»
Researchers publish mitochondrial genome of long-spined sea urchin, guardian of Caribbean coral reefs
A team of Oakland University researchers has published the first complete mitochondrial genome of Diadema antillarum, commonly known as the long-spined sea urchin. The invertebrate marine herbivore inhabits the shallow waters of the Western Atlantic.....»»
Stresses and hydrodynamics: Scientists uncover new organizing principles of the genome
A team of scientists has uncovered the physical principles—a series of forces and hydrodynamic flows—that help ensure the proper functioning of life's blueprint. Its discovery provides new insights into the genome while potentially offering a new.....»»
New DNA analysis provides first accurate tuberculosis genome
Researchers have developed a novel genome assembly tool that could spur the development of new treatments for tuberculosis and other bacterial infections......»»
Scandinavian wolves found to carry many harmful mutations
In a new scientific study, researchers at Uppsala University have shown that Scandinavian wolves carry around 100,000 harmful mutations in their genome. As long as the harmful mutations can be compensated by a healthy genetic variant, this does not n.....»»
3D models reveal, at the atomic scale, how FoxH1 binds to specific points in the genome
Transcription factors are proteins that interact with DNA to regulate the function of some genes. Generally, a single transcription factor binds to several regions in the genome as it orchestrates complex cellular responses, which require the activat.....»»
Atopic dermatitis in dogs linked to certain parts of the genome
Using new gene mapping methods, researchers have found connections between atopic dermatitis (eczema) in dogs and several regions of the genome. Some of the genes identified coincide with genes linked to similar problems in humans. The filaggrin gene.....»»
How TFIIH uses XPG to located damaged DNA
Nucleotide excision repair (NER) is a critical DNA repair pathway that plays a key role in maintaining transcription and genome integrity by removing bulky DNA lesions......»»
Oldest DNA yet sequenced shows mastodons once roamed a warmer Greenland
DNA left behind during a warm period is viable 2 million years later. Enlarge / An attempt to reconstruct what northern Greenland looked like about 2 million years ago. (credit: Beth Zaiken) When once-living tissue is pr.....»»
Health Big Data Platform Program takes on responsibility to drive precision medicine in Taiwan
The completion of human genome sequencing has given rise to the trend of precision medicine and prompted governments worldwide to formulate the relevant healthcare policies. Meanwhile, Taiwan's healthcare standard, and information and communication t.....»»
Can the three-dimensional organization of the T cell genome regulate (auto)immunity?
The research team of Associate Professor Charalampos G. Spilianakis, an affiliated Professor at the Institute of Molecular Biology and Biotechnology of FORTH, has been working on determining whether the three-dimensional organization of the T cell ge.....»»
RNA enzyme ensures development of red blood cells by safeguarding genome integrity
The body needs a lot of blood. In humans, 200 billion new erythrocytes—or red blood cells—are generated daily by erythropoiesis, a multi-step process starting from blood-related stem cells, requiring rigorous maintenance of DNA integrity. Until n.....»»
Exploring how totipotency pioneer factor Nr5a2 activates the genome in zygotes
Fertilization of an egg by sperm is the beginning of new life. The maternal and paternal genetic information, that collectively store the body plan of the living being, are combined after fertilization......»»
Genome studies uncover a new branch in fungal evolution
About 600 seemingly disparate fungi that never quite found a fit along the fungal family tree have been shown to have a common ancestor, according to a University of Alberta-led research team that used genome sequencing to give these peculiar creatur.....»»
Researchers map Hass avocado genome
What makes the perfect avocado?.....»»
Zombie viruses on a hijacking trip: How retroviral gene fragments affect embryonic cells
Ancient, dormant sequences in the genome impact embryonic development in unexpected ways. The mammalian genome contains retroviral sequences that are in an undead but mostly "harmless" state. An international research team recently discovered how som.....»»
We now have a pretty good idea what the “Connecticut vampire” looked like
Targeted whole genome analysis strengthens case that he was a man named John Barber. Enlarge / Forensic facial reconstruction of the "Connecticut vampire" (aka JB55), accounting for known tooth loss and inferred health issues. Ha.....»»