Dissecting caspase-2-mediated cell death: From intrinsic PIDDosome activation to chemical modulation
Caspase-2, an initiator caspase, plays a critical role in programmed cell death in response to certain cellular stresses. Its activation is facilitated by the PIDDosome, a multi-protein complex that assembles under conditions of genotoxic stress. Des.....»»
Centromeres could be "hotspots" for evolutionary innovation
New research reveals that centromeres, which are responsible for proper cell division, can rapidly reorganize over short time scales. Biologists at the University of Rochester are calling a discovery they made in a mysterious region of the chromosome.....»»
Ultrafast electron imaging captures never-before-seen nuclear motions in hydrocarbon molecules excited by light
The interactions between light and nitroaromatic hydrocarbon molecules have important implications for chemical processes in our atmosphere that can lead to smog and pollution. However, changes in molecular geometry due to interactions with light can.....»»
The death of a robot designed for autistic children proves Apple"s on-device AI is the right path
The Moxie robot that used cloud processing for a large language model was designed to be a companion and education tool for autistic children, and it's being unceremoniously shut down by the owners. This absolutely insensitive and destructive move pr.....»»
Keira Knightley knew that Love Actually cue card scene was creepy from the jump
The scene has been meme'd to death, and Knightley now says that it stalker-ish implications were always there......»»
Watch Yellowstone season 5, episode 13: release date, time, channel, and plot
Another death and more Dutton family drama dominated last week's Yellowstone. Find out how and when to watch Yellowstone season 5, episode 13......»»
Computer modeling shows close encounters between distant DNA regions cause bursts of gene activity
Researchers at Kyushu University have revealed how spatial distance between specific regions of DNA is linked to bursts of gene activity. Using advanced cell imaging techniques and computer modeling, the researchers showed that the folding and moveme.....»»
Nanoparticle-mediated gene therapy fixes major cause of stillbirth and premature birth in guinea pig model
The life of billions of people inhabiting Earth is owed to a temporary organ that supported and nourished them in a mother's womb. The placenta, or afterbirth, is considered sacred by some cultures, its pivotal role in pregnancy recognized as far bac.....»»
Experiments provide evidence that interaction of light with a hydrocarbon molecule produces strained molecular rings
When molecules interact with ultraviolet (UV) light, they can change shape quickly, producing strain—stress in a molecule's chemical structure due to an increase in the molecule's internal energy. These processes typically take just tens of picosec.....»»
Discovery of key protein complex shows evolution and adaptability of photosynthetic organisms
A team of researchers has revealed the structure of a modified and evolved version of Photosystem I (PS I), a key protein complex used by plants and cyanobacteria to convert sunlight into chemical energy. This discovery sheds light on the evolution a.....»»
Scientists develop ultrasound-based technique as a tool for directing cell growth and orientation
Developing reliable methods to replace dead or damaged tissue is one of the primary goals of regenerative medicine. With steady advances in tissue engineering and biomedicine, scientists are almost at a point where growing cell sheets in the lab and.....»»
Screening study explores risks of chemical exposure from household products
Southwest Research Institute (SwRI) collaborated with the Environmental Protection Agency (EPA) to characterize the chemical makeup of 81 common household items. Researchers also evaluated the potential risk to users......»»
Novel covalent organic framework can remove a dangerous "forever chemical" from drinking water
Researchers at NYU Abu Dhabi (NYUAD) have developed an innovative cationic covalent organic framework (COF) that efficiently detects and removes perfluorooctanoic acid (PFOA), a harmful and persistent pollutant, from drinking water. This breakthrough.....»»
Q&A: Researcher discusses protecting the health of wildlife ecosystems
The plague is one of the deadliest bacterial infections in human history. An estimated 50 million Europeans died from it in the mid-1300s when it was known as the "Black Death.".....»»
A key transcription factor unlocks new potential in stem cell-based embryo models
Researchers from the A*STAR Institute of Molecular and Cell Biology (IMCB) have identified Nr1h2, a critical transcription factor essential for early embryo development. Published in Nature Communications, their findings enhance our understanding of.....»»
Discovery of molecular switch explains how bacteria control their protein biosynthesis through cell metabolism
Protein biosynthesis—the process whereby cells produce protein molecules, which are essential for life and growth—is a highly complex and strictly regulated affair. An interdisciplinary team led by LMU biologist PD Dr. Jürgen Lassak has now disc.....»»
HowStuffWorks founder Marshall Brain sent final email before sudden death
Popular tech educator died in his office within hours of claiming retaliation for filing NCSU ethics reports. The week before Thanksgiving, Marshall Brain sent a final email to hi.....»»
Death toll rises to 29 in southern Thailand floods
More than 30,000 people have been forced to flee their homes due to severe flooding in southern Thailand, where the death toll climbed to 29, officials said Wednesday......»»
Poplar tree study discovers a photosynthesis gene that boosts plant height
A team of scientists have identified a gene in poplar trees that enhances photosynthesis and can boost tree height. The study, "An orphan gene BOOSTER enhances photosynthetic efficiency and plant productivity," is published in Developmental Cell, and.....»»
Chemical structure"s carbon capture ability doubled by new research
Oregon State University scientists have found a way to more than double the uptake ability of a chemical structure that can be used for scrubbing carbon dioxide from factory flues......»»
Open-source platform supports large imaging data analysis of single cell responses to manipulation
Modern day drug discovery is shifting from single end point assays to more complex phenotypic assays that query single cell and population responses to chemicals and genetic manipulation......»»