Demonstrating the significance of individual molecules during mechanical stress in cells
The cells in our bodies are continuously exposed to mechanical forces that are either externally applied or generated by the cells themselves. Being able to respond to such mechanical stimuli is an indispensable prerequisite for a large number of bio.....»»
Scientists develop a new method to study gene function in cells and tissue
The Gaublomme lab has developed a new optical pooled screening approach called CRISPRmap, which enables the coupling of optical properties of single cells to targeted genetic perturbations. Optical phenotypes are typically inaccessible for sequencing.....»»
Shaping nanocrystals: Unlocking the future of screens, solar and medical tech
From brighter TV screens to better medical diagnostics and more efficient solar panels, new Curtin-led research has discovered how to make more molecules stick to the surface of tiny nanocrystals, in a breakthrough that could lead to improvements in.....»»
Novel nanoparticle therapy targets fat absorption to combat obesity
Researchers have unveiled a novel approach to tackle obesity by targeting fat absorption in the small intestine. The cutting-edge nanoparticle system, engineered to deliver therapeutic molecules directly to the digestive tract, has shown significant.....»»
Researchers create a three-dimensional multi-focus laser for glass micro-sculpting
Glass materials are widely used in optical and optoelectronic devices due to their low cost and excellent mechanical and optical properties. Among them, glass concave/convex linear structures with feature sizes ranging from several micrometers to hun.....»»
Targeting "undruggable" diseases: Researchers reveal new levels of detail in targeted protein degradation
Researchers at the University of Dundee have revealed in the greatest detail yet the workings of molecules called protein degraders which can be deployed to combat what have previously been regarded as "undruggable" diseases, including cancers and ne.....»»
Study proposes that proteins can compartmentalize and form droplets inside cells
In physics, a system composed of two substances can be modeled in accordance with classical mixture theory, which considers the fraction corresponding to each constituent and the interactions among constituents. Examples include the coexistence of hi.....»»
Plant stem cells: Understanding the biological mechanism of growth control
Researchers from the University of Freiburg have identified the HAN molecule as an important regulator that controls plant growth in conjunction with WOX5. Understanding this mechanism is relevant for breeding more resilient or higher-yielding crops......»»
Oxidative stress: How protein recycling protects against cell death
Researchers at LMU University Hospital have discovered a new molecular switch that protects against cell death......»»
Expansion technique to image nanoscale structures inside cells makes high-resolution imaging more accessible
A classical way to image nanoscale structures in cells is with high-powered, expensive super-resolution microscopes. As an alternative, MIT researchers have developed a way to expand tissue before imaging it—a technique that allows them to achieve.....»»
A look into "mirror molecules" may lead to new medicines
A University of Texas at Dallas chemist and his colleagues have developed a new chemical reaction that will allow researchers to synthesize selectively the left-handed or right-handed versions of "mirror molecules" found in nature and assess them for.....»»
Claustrophobic cells slow their own growth, forming beautiful patterns of concentric circles
Like so many organisms on the planet, when cells experience mosh-pit-level crowding, they may just become stressed. Yet unlike most other life forms, cells subject to physical stress from crowding by neighbors can find some relief by dramatically slo.....»»
Advanced model predicts gene architecture via nucleosome position
DNA—the molecule that carries the genetic information of all living organisms—is packaged within cells in a complex manner that allows it to function efficiently. Nucleosomes facilitate DNA compaction and also play a crucial role in regulating ge.....»»
From chaos to structure: How a bunch of seemingly disorganized cells go on to form a robust embryo
Pipetting liquids into tiny test tubes, analyzing huge datasets, poring over research publications—all these tasks are part of being a scientist. But breaking this routine is essential. Time away from the usual work environment can spark creative i.....»»
Spectroscopy study determines how catalysts remove dangerous nitrogen oxides
Catalysts belonging to the zeolite family help to remove toxic nitrogen oxides from industrial emissions. Researchers at the Paul Scherrer Institute PSI have now discovered that their complex nano porous structure is crucial. Specifically, individual.....»»
Assessment of damaged archaeological sites suggests they require individual protection concepts
An analysis of the damage to archaeological sites documented after a heavy rainfall event in July 2021 in parts of Germany shows that several factors increase the risk of damage to archaeological sites due to heavy rainfall and flooding events. For e.....»»
Making micelles more effective for dye and drug dispersion through well-defined core-shell structures
Micelles are spherical molecular structures usually formed by amphiphilic molecules with block structure, which contain both hydrophilic and hydrophobic parts. The hydrophobic tails of these molecules cluster together to form a core, while the hydrop.....»»
New tool provides knowledge on heat stress vulnerability in cities for more targeted adaptation
Heat-related deaths and diseases are a major concern in Europe amid increasing extended periods of extreme heat. A recent study proposes a novel way of quantifying and projecting future vulnerability to heat stress in different areas of a city, provi.....»»
Severe solar storm could stress power grids even more as US deals with major back-to-back hurricanes
A severe solar storm is headed to Earth that could stress power grids even more as the U.S. deals with major back-to-back hurricanes, space weather forecasters said Wednesday......»»
How Chlamydia pneumoniae bacteria use molecular mimicry to manipulate the host cell
Bacteria that cause diseases, so-called pathogens, develop various strategies to exploit human cells as hosts to their own advantage. A team of biologists from Heinrich Heine University Düsseldorf (HHU), together with medical professionals and exper.....»»
Researchers discover how plants produce a novel anti-stress molecule
New research identifies for the first time the genes that help plants grow under stressful conditions—with implications for producing more sustainable food crops in the face of global climate change......»»