Basement membrane underpins tissue interactions in the skin
In a discovery that could pave the way for therapies that promote wound healing and alleviate skin diseases, RIKEN researchers have found that the network of molecules under the outermost layer of mouse skin, the skin epithelium, is a highly speciali.....»»
Research challenges "universal mechanism" concept, aiming to understand specific protein interactions
Heat shock proteins (HSPs) are the chaperones of cellular stress response because they help guide the folding and unfolding of other proteins......»»
Researchers identify key regulators underlying regeneration in Drosophila
Some animals possess the remarkable ability to regenerate lost structures, exemplified by a lizard regrowing its tail. However, this regenerative process must be tightly regulated by the body to ensure proper tissue organization and to prevent abnorm.....»»
Tracking and tracing members of the plant microbiome with DNA barcodes
A research team led by Paul Schulze-Lefert from the Max Planck Institute for Plant Breeding Research in Cologne, Germany, developed a modular toolkit for tracking bacterial strains colonizing plant tissue in competition with other microbiome members......»»
New archive of ancient human brains challenges misconceptions of soft tissue preservation
Soft tissue preservation in the geological record is relatively rare, and except where deliberate intervention halts the process of decay (like embalming or freezing), the survival of entire organs is particularly unusual. The spontaneous preservatio.....»»
Latest Apple Store reveals beautiful circular design [Gallery]
Apple has shared photos of the latest Apple Store, ahead of this week’s opening in Shanghai, China. The photos reveal a curved glass facade, with stairs leading down into a beautiful circular design in the main display area in the basement of th.....»»
Researchers develop novel "super-tetragonal" sacrificial layer for freestanding oxide membranes
Researchers have developed a new water-soluble sacrificial layer, "super-tectragonal" Sr4Al2O7 (SAOT), with broad tunability in lattice constants, which can be used to prepare high-quality freestanding oxide membrane. Their work is published in Scien.....»»
Tropical plants beat drought by interacting with specific microbes, study shows
Plant-soil-microbe interactions play a crucial role in processes that take place in the soil directly around plant roots, or the rhizosphere, and these processes contribute to nutrient cycling and metabolite turnover in the environment. Amid the wate.....»»
In vivo production of CAR-T cells using virus-mimetic fusogenic nanovesicles
Chimeric antigen receptors (CARs) are synthesized membrane proteins that enable lymphocytes to recognize and respond to the specific antigens of target cells. Despite the impressive efficacy of CAR-T cell therapy in treating B-cell lymphoma or leukem.....»»
Research uncovers specific protein interactions needed for cells to break down and remove damaged mitochondria
Autophagy is a process used by cells as a recycling system to transport and break down organelles and other cytosolic components, which become enveloped in a membrane called the autophagosome. When this involves the removal of damaged mitochondria, i.....»»
Polarization-sensitive tomography made easy with tensorial tomographic Fourier ptychography
In the realm of medical imaging, there are quite a few different techniques to extract information from biological tissue based on its different interactions with visible light. Over the past decade, there has been a massive surge in research focusin.....»»
Advancing tissue engineering with shape memory hydrogels
One of the primary goals in the field of tissue engineering and regenerative medicine is the development of artificial scaffolds that can serve as substitutes for damaged tissue. These materials must ideally resemble natural tissue and must have the.....»»
Can genetic parasites alter interactions between microbes and hosts?
Researchers from the Max Planck Institutes (MPI) for Evolutionary Biology in Plön and for Biology in Tübingen have made significant progress in understanding the evolution of interactions between plants and microbes. The study focuses on Pseudomona.....»»
Sugar-coated gold nanoparticles can quickly eliminate bacterial infections, no antibiotics required
If left to their own devices, bacteria on our teeth or wounded skin can encase themselves in a slimy scaffolding, turning into what is called biofilm. These bacteria wreak havoc on our tissue and, being shielded from antibiotic medication by the slim.....»»
New computational strategy boosts the ability of drug designers to target proteins inside the membrane
Hitting targets embedded within the cell membrane has long been difficult for drug developers due to the membrane's challenging biochemical properties. Now, Scripps Research chemists have demonstrated new custom-designed proteins that can efficiently.....»»
Team makes progress with fluorescent dyes to better visualize lipid membrane order in live cells
A new solvatochromic probe could help shed light on the relationship between lipid membrane fluidity and various cellular functions, report scientists at Tokyo Institute of Technology and Kyushu University. Thanks to an innovative design, the propose.....»»
Our bacteria are more personal than we thought, new study shows
The trillions of bacteria that call your body home—collectively known as the microbiome—appear to be unique to you, like a fingerprint. That's one conclusion of a detailed study of the gut, mouth, nose and skin microbiomes of 86 people. Over the.....»»
Mars attracts: How Earth"s interactions with the red planet drive deep-sea circulation
Scientists from the Universities of Sydney and Sorbonne University have used the geological record of the deep sea to discover a connection between the orbits of Earth and Mars, past global warming patterns and the speeding up of deep ocean circulati.....»»
How cells in developing embryos change the way they use enhancers to regulate gene expression
If you look at a nerve cell, a muscle cell, or a skin cell under the microscope, they appear strikingly different. However, every cell in our body has the same DNA and has descended from a common ancestor—the fertilized egg cell. The diversity we o.....»»
"Are we dating the same guy?" These women-run groups are accused of being toxic, but they carry a feminist legacy
In 2022, a social network was formed in New York for women to share warnings about their interactions with men on dating apps. These were men who had allegedly lied, manipulated, cheated on, ghosted, used or abused them......»»
Vitamin A may play a central role in stem cell biology and wound repair
When a child falls off her bike and scrapes her knee, skin stem cells rush to the rescue, growing new epidermis to cover the wound. But only some of the stem cells that will ultimately patch her up are normally dedicated to replenishing the epidermis.....»»