Using adavosertib-encapsulated MOFs for p53-mutated gallbladder cancer treatment via synthetic lethality
Since the revelation of poly(ADP-ribose) polymerase (PARP) inhibitors and their remarkable results in the treatment of BRCA1/2 mutant cancers, synthetic lethality (SL) in antitumor therapy has attracted increasing attention. SL is a phenomenon in whi.....»»
Understanding cellular transcription responses to oxygen deprivation
A multiprotein complex is essential for regulating cellular responses to oxygen deprivation, a key feature of cancer, according to a Northwestern Medicine study published in the Proceedings of the National Academy of Sciences......»»
Researchers turn to two crops to tackle environmental harm of apparel made with synthetic fibers
From risottos to sauces, mushrooms have long been a staple in the kitchen. Now fungi are showing the potential to serve up more than just flavor—as a sustainable, bendy material for the fashion industry......»»
Researchers discover key functions of therapeutically promising jumbo viruses
Antibiotic medicines became a popular treatment for bacterial infections in the early 20th century and emerged as a transformational tool in human health. Through the middle of the century, novel antibiotics were regularly developed in the medication.....»»
Study reveals cancer vulnerabilities in popular dog breeds
Medium-sized dogs have a higher risk of developing cancer than the very largest or smallest breeds, according to a UC Riverside study......»»
Scientists construct sophisticated synthetic system using self-replicating nanostructures
A research team led by the late Professor Liang Haojun from the Hefei National Laboratory for Physical Sciences at the Microscale of University of Science and Technology of China (USTC) has developed a facile enthalpy-mediated strategy to precisely c.....»»
Fruit fly helps unlock clues about how organs, tissue and cancer grow
The fruit fly, Drosophila, has been used by scientists for more than 100 years to unravel key features of life on Earth, such as how animals respond to the sun and how the bodies of animals are patterned from head to tail......»»
New structures offer insight into how a bacterial motor powers bacterial chemotaxis, a key infectious process
Bacteria existed for millennia before humans and have been infecting us from the beginning. Although we can treat infections through pharmaceuticals, bacteria continue to become resistant to treatment thanks to their rapid evolution. Bacterial infect.....»»
Scientists develop novel liquid metal alloy system to synthesize diamond under moderate conditions
Did you know that 99% of synthetic diamonds are currently produced using high-pressure and high-temperature (HPHT) methods? A prevailing paradigm is that diamonds can only be grown using liquid metal catalysts in the "gigapascal pressure range" (typi.....»»
Giant virus discovered in wastewater treatment plant infects deadly parasite
The single-celled organism Naegleria fowleri ranks among the deadliest human parasites. Researchers around Matthias Horn and Patrick Arthofer from the Center for Microbiology and Environmental Systems Science at the University of Vienna, in an intern.....»»
Scientists study lipids cell by cell, making new cancer research possible
Imagine being able to look inside a single cancer cell and see how it communicates with its neighbors. Scientists are celebrating a new technique that lets them study the fatty contents of cancer cells, one by one......»»
Lakes worldwide are facing a slew of health issues that may become chronic
Like humans, lakes are living systems that can suffer from a number of health issues, including circulatory and respiratory problems, infections, nutritional imbalances, and heat-related illnesses. Without treatment, these conditions can become chron.....»»
Light-activated materials perform well in treatment of textile effluent
Photoelectrochemical processes have been considered sustainable alternatives for the remediation of water contaminated by domestic or industrial effluents. Simply put, the strategy consists of using solar energy to degrade organic pollutants......»»
A universal framework for spatial biology
Biological processes are framed by the context they take place in. A new tool developed by the Stegle Group from EMBL Heidelberg and the German Cancer Research Center (DKFZ) helps put molecular biology research findings in a better context of cellula.....»»
Gregg Orr Auto to pay $325,000 to settle allegations it fired employee with cancer
Gregg Orr Auto Collection agreed to settle a lawsuit in which the U.S. Equal Employment Opportunity Commission alleged an older employee with cancer was fired because of his high medical bills......»»
Toxic fireproof chemicals can be absorbed through touch, 3D-printed skin model shows
Cancer-causing flame retardants found in everyday things like plastics, furniture, fabrics and electronics can be sucked up by the skin and absorbed into the bloodstream in 24 hours, scientists have found......»»
Researchers uncover human DNA repair by nuclear metamorphosis
Researchers at the University of Toronto have discovered a DNA repair mechanism that advances understanding of how human cells stay healthy, and which could lead to new treatments for cancer and premature aging......»»
Nanoparticle delivery of FZD4 to lung endothelial cells inhibits lung cancer progression and metastases
A recent study from the lab of Tanya Kalin, MD, Ph.D., professor of Child Health and Internal Medicine at the University of Arizona College of Medicine—Phoenix, has shown potential to improve therapeutic outcomes for patients suffering from lung ca.....»»
Nanovials method for immune cell screening uncovers receptors that target prostate cancer
A recent UCLA study demonstrates a new process for screening T cells, part of the body's natural defenses, for characteristics vital to the success of cell-based treatments. The method filters T cells based on the receptor proteins found on their sur.....»»
A young Black scientist discovered a pivotal leprosy treatment in the 1920s—but an older colleague took the credit
Hansen's disease, also called leprosy, is treatable today—and that's partly thanks to a curious tree and the work of a pioneering young scientist in the 1920s. Centuries prior to her discovery, sufferers had no remedy for leprosy's debilitating sym.....»»
Switch to green wastewater infrastructure could reduce emissions and provide huge savings, new research finds
University researchers have shown that a transition to green wastewater-treatment approaches in the U.S. that leverages the potential of carbon-financing could save a staggering $15.6 billion and just under 30 million metric tons of CO2-equivalent em.....»»