Unfolding the blindness proteins through fly eyes
Every 6 minutes someone is told they're going blind. One of the major causes of human blindness is a disease called Retinitis Pigmentosa (RP), which causes progressive degeneration of the retina and vision loss. Approximately one-tenth of Retinitis.....»»
Nissan eyes next-gen EVs, hybrids, 1 million more sales in aggressive new 3-year plan
Nissan said it will launch seven “all-new” models in the U.S. and Canada over the next three years, as part of the push. And the company pledged to refresh 78 percent of its U.S. lineup in that time......»»
Researchers devise new way to find proteins for targeted treatment of disease
Researchers at the University of Toronto and Sinai Health have created a new platform to identify proteins that can be co-opted to control the stability of other proteins—a new but largely unrealized approach to the treatment of disease......»»
Why is DNA almost always a right-handed helix? Exploring the causes of chirality
Why is the heart slightly on the left side of the body for most people? Why is DNA almost always a right-handed helix? Same with alpha helices, the building blocks of proteins. Chirality, or handedness, is everywhere in biology, but the reasons can b.....»»
Messenger RNAs with multiple "tails" could lead to more effective therapeutics, say researchers
Messenger RNA (mRNA) made its big leap into the public limelight during the pandemic, thanks to its cornerstone role in several COVID-19 vaccines. But mRNAs, which are genetic sequences that instruct the body to produce proteins, are also being devel.....»»
Decoding the plant world"s complex biochemical communication networks
A Purdue University-led research team has begun translating the complex molecular language of petunias. Their grammar and vocabulary are well hidden, however, within the countless proteins and other compounds that fill floral cells......»»
High speed protein movies to aid drug design
Researchers from the University of Southampton have developed technology to help scientists observe proteins in motion. Understanding how proteins move will allow novel drugs to be designed......»»
Research challenges "universal mechanism" concept, aiming to understand specific protein interactions
Heat shock proteins (HSPs) are the chaperones of cellular stress response because they help guide the folding and unfolding of other proteins......»»
Research suggests natural electrical grid deep inside Earth enables many types of microbes to survive
To "breathe" in an environment without oxygen, bacteria in the ground beneath our feet depend upon a single family of proteins to transfer excess electrons (produced during the "burning" of nutrients) to electric hairs called nanowires projecting fro.....»»
Astrophysicist explains science behind once-in-a-lifetime nova outburst that will light up the sky this year
The total solar eclipse isn't the only reason to keep your eyes to the sky this year. For the first time in 80 years, a star system 3,000 light years away will be visible to the naked eye thanks to a once-in-a-lifetime nova outburst......»»
Eyes open and toes out of water: How a giant water bug reached the island of Cyprus
The island of Cyprus, although considered a hotspot for biodiversity in the Mediterranean, is more famous for its beautiful sunny coasts than for its insect fauna. Nevertheless, some visitors of its highly populated beaches, with their observations a.....»»
Eyes on the impossible: First near-field, subwavelength thermal radiation measurement
Nanodevices change the way we diagnose disease, process food and water, and store renewable energy. But to keep up with next-generation technology, researchers need to understand the fundamental principles that prompt their functionality......»»
In vivo production of CAR-T cells using virus-mimetic fusogenic nanovesicles
Chimeric antigen receptors (CARs) are synthesized membrane proteins that enable lymphocytes to recognize and respond to the specific antigens of target cells. Despite the impressive efficacy of CAR-T cell therapy in treating B-cell lymphoma or leukem.....»»
Shrimp waste revolution: Unlocking potent antioxidants for health and sustainability
Shrimp are renowned for their high nutritional value, offering a rich source of proteins, amino acids, omega-3 fatty acids, minerals, and vitamins, as well as chitin and carotenoids. The increasing consumption of shrimp has led to a significant rise.....»»
New computational strategy boosts the ability of drug designers to target proteins inside the membrane
Hitting targets embedded within the cell membrane has long been difficult for drug developers due to the membrane's challenging biochemical properties. Now, Scripps Research chemists have demonstrated new custom-designed proteins that can efficiently.....»»
A simple and robust experimental process for protein engineering
A protein engineering method using simple, cost-effective experiments and machine learning models can predict which proteins will be effective for a given purpose, according to a new study by University of Michigan researchers......»»
Scientists develop deep learning method to design bilin-binding proteins
David Baker's group at the University of Washington, Seattle, U.S., have developed a novel deep learning method, RoseTTAFold All-Atom (RFAA), for prediction and design of complexes of proteins, small molecules, and nucleic acids. Subsequently, they d.....»»
How cells manage their mRNA stockpile and its output
In a typical cell, genes encoded in DNA are used to make messenger RNA (mRNA), which is used to make proteins, and this process of gene expression keeps the cell running. Gene expression is regulated in each cell such that specific genes are turned o.....»»
Research team develops new technique to release and study individual proteins in cells
A research team led by biochemist Professor Helge Ewers from Freie Universität Berlin has developed a new technique for the light-mediated release and investigation of proteins in live cells. The technique makes use of a laser pulse to control the r.....»»
How green corridors are breathing new life into French forests
In the summer of 2008, during a family holiday road trip, we passed by the Aquitaine region in southwestern France. As we drove through a sprawling woodland, a mesmerizing sight unfolded before my eyes: a meticulously ordered army of trees, standing.....»»
Australia"s Great Barrier Reef in grip of "mass bleaching event"
A "mass bleaching event" is unfolding on Australia's famed Great Barrier Reef, authorities said Friday, as warming seas threaten the spectacular home to thousands of marine species......»»