Three chaperones coordinate the breakup of amyloid fibrils in yeast
In a finding that has important ramifications for neurodegenerative disorders such as Alzheimer's disease, RIKEN researchers have discovered how three chaperone molecules in yeast cells work together to break up beta-sheet-rich fibrillar protein aggr.....»»
Serum amyloid A: Exploring links between the beneficial and pathologic actions of an enigmatic protein
Serum amyloid A (SAA) is a family of ancient proteins that can be traced from present-day humans back half a billion years to sea cucumbers and oysters. A new study by researchers from the Boston University Chobanian & Avedisian School of Medicine ex.....»»
Future Apple Watch could color-coordinate itself automatically
Apple may never allow us to create whole Apple Watch faces ourselves, but it is looking at how you could show the Watch a band, or any object, and have it adapt to its color.For eight years, users — or at least third-party firms — have wanted the.....»»
A New Blood Test May Predict Your Alzheimer’s Risk. Should You Take It?
The test, which consumers can order on their own, measures a protein linked to Alzheimer’s called amyloid beta. But it can’t diagnose cases, and the results may be needlessly stressful......»»
Alzheimer"s Drug Donanemab Helps Most When Taken Early in Disease
An Alzheimer’s drug that attacks the protein amyloid does not work as well in people with more advanced disease.....»»
Light-activated molecular machines get cells "talking"
One of the main ways cells "talk" to each other to coordinate essential biological activities such as muscle contraction, hormone release, neuronal firing, digestion and immune activation is through calcium signaling......»»
Biden taps a Michigan native to smooth upcoming UAW talks
Michigan native Gene Sperling, a senior adviser to President Joe Biden, is being tapped to coordinate the administration's bid to facilitate smooth contract talks between the Detroit Three automakers and United Auto Workers union. Sperling is the.....»»
We finally know how the mysterious Geminid meteor shower originated
A probe sent toward the Sun ran into the debris of an asteroid breakup. Enlarge / The Geminids put on quite a show each year. (credit: NASA.gov) Each year, skywatchers get to gaze at the spectacle of the Geminids streaki.....»»
Yeast dust makes a cheap, fast virus test
Researchers from The University of Queensland have made a dust from baker's yeast that can detect COVID-19 and could safeguard communities against future pandemics......»»
Do hummingbirds drink alcohol? More often than you think
You may not realize it, but that backyard hummingbird feeder filled with sugar water is a natural experiment in fermentation—yeast settle in and turn some of the sugar into alcohol......»»
Revealing magnetic mysteries: Breakthrough builds better single molecule magnets
Scientists from the University of Ottawa have invented a unique method to create better molecule-based magnets, known as single-molecule magnets (SMMs). This synthetic tour de force has resulted in a two-coordinate lanthanide complex which has magnet.....»»
Computational mid-infrared photothermal imaging unveils intracellular tau aggregates
As a prominent form of amyloid protein, tau aggregates have emerged as a primary focus of research for uncovering the mechanisms underlying neurodegeneration. Various types of tau aggregates, including tau fibrils and oligomers, have been implicated.....»»
Scientists quantify regulation factors contributing to flux changes in the central metabolic pathway in yeast
Metabolic reaction flux change is the final result of interacting regulations by intracellular gene expression, transcriptional regulation, protein level, translation modification, and allosteric effect. However, the regulatory mechanism of metabolic.....»»
Google risks forced breakup of ad business as EU alleges shocking misconduct
Google could lose huge parts of its $225 billion ad business. Enlarge (credit: Thomas Trutschel / Contributor | Photothek) Google may soon be ordered to break up its lucrative ad business, which amounted to nearly $225 b.....»»
Retooling the ribosomal translation machine could expand chemical repertoire of cells
Synthetic biologists have become increasingly creative in engineering yeast or bacteria to churn out useful chemicals—from fuels to fabrics and drugs—beyond the normal repertoire of microbes......»»
New UAW leadership: ‘Time to get our fair share"
Shawn Fain, the first UAW president elected directly by members, is working to coordinate the union's messaging from the bottom up to build pressure on the Detroit 3......»»
New Alzheimer’s Drugs Offer Subtle Benefits—With Real Risks
Antibody treatments clear amyloid protein from patients’ brains, slowing the progression of their disease but potentially inducing deadly swelling......»»
Meta sells Giphy at a significant loss after UK breakup order
Stock-photo website Shutterstock on Tuesday said it will acquire Giphy and its online repository of animated images for $53 million, after UK antitrust regulators forced Meta to spin off the company last year......»»
New insights into the complex neurochemistry of ants
Ants' brains are amazingly sophisticated organs that enable them to coordinate complex behavior patterns such as the organization of colonies. Now, a group of researchers led by Christian Gruber of MedUni Vienna's Institute of Pharmacology have devel.....»»
German researchers figure out how lager first developed in Bavaria
A new paper in FEMS Yeast Research reveals the possible origin story of lager beers. Using historical records and contemporary phylogenomics research, investigators here show where lagers likely first originated: at the court brewery (Hofbräuhaus) o.....»»
Novel living yeast-based dual biosensor for detecting peptide variants
Biosensors—sensors that can detect biological samples—are powerful tools for understanding the function, composition, and structure of biochemical molecules. Biosensors are often applied for the detection of proteins and their subunits, called pe.....»»