SARS-CoV-2: Neutralization of BA.1 and BA.2 by therapeutic monoclonal antibodies
Scientists studied the sensitivity of Omicron BA.1 and BA.2 to nine monoclonal antibodies, some of which are used in pre-exposure prophylaxis in immunocompromised individuals. The scientists showed a loss of neutralizing activity against BA.1 and BA......»»
Safety of aquatic animals as human protein sources amid SARS-CoV-2 concerns
Aquatic animals have historically constituted a vital and nutritious dietary component for humans, contributing to nearly 20% of animal protein intake for approximately 3.3 billion people. Unlike terrestrial animals, there has been no evidence indica.....»»
Researchers develop self-assembling, self-illuminating therapeutic proteins
When it comes to delivering drugs to the body, a major challenge is ensuring that they remain in the area they're treating and continuing to deliver their payload accurately. While major strides have been made in delivering drugs, monitoring them is.....»»
Protein allows poison dart frogs to accumulate toxins safely, shows study
Scientists have identified the protein that helps poison dart frogs safely accumulate their namesake toxins, according to a study published today in eLife. The findings solve a long-standing scientific mystery and may suggest potential therapeutic st.....»»
Photodynamic action weakens resistance to antibiotics in bacteria that attack airways
The development of antibiotics to combat multidrug-resistant bacteria, especially those that infect the airways, has been increasingly tricky, and some scientists have opted to try to weaken the bacteria so that the available therapeutic substances a.....»»
Nanoparticles amplify potential cancer vaccine power
Johns Hopkins researchers have identified minuscule particles that supercharge therapeutic cancer vaccines, which train the immune system to attack tumors. These new lipid nanoparticles—tiny structures made of fat—not only stimulate a two-pronged.....»»
Could the "central dogma" of biology be misleading bioengineers?
Today, medicines based on antibodies—proteins that fight infection and disease—are prescribed for everything from cancer to COVID-19 to high cholesterol. The antibody drugs are supplied by genetically-engineered cells that function as tiny protei.....»»
Novel insights into antibody aggregation expected to open up new avenues for research and therapeutic applications
Antibodies (immunoglobulins) are Y-shaped proteins that recognize and neutralize specific pathogens. Their ability to target specific molecules or cells has made them promising candidates for future drug development. However, their light chains—par.....»»
Researchers crack the cellular code on protein folding, offering hope for many new therapeutic avenues
While we often think of diseases as caused by foreign bodies—bacteria or viruses—there are hundreds of diseases affecting humans that result from errors in cellular production of proteins......»»
Scientists navigate uncharted waters in fish immunology research
Upon infection or immunization, all jawed vertebrate species generate proteins called antibodies that bind and neutralize pathogens. Strong and long-lasting antibody responses in warm-blooded species such as mammals are produced in secondary lymphoid.....»»
Researchers identify dynamic behavior of key SARS-CoV-2 accessory protein
Researchers at Kanazawa University report in the Journal of Physical Chemistry Letters high-speed atomic force microscopy studies that shed light on the possible role of the open reading frame 6 (ORF6) protein in COVID-19 symptoms......»»
Team discovers protein crucial for B cell differentiation and antibodies
A cell nucleus is a busy place. Cellular proteins twist and pull DNA, folding the genome into intricate 3D structures that support functioning of its coding parts......»»
Using single-antibodies as a new tool to build bio-circuitry
By using single-antibodies, Professor Hirohide Saito (Department of Life Science Frontiers) and his team of researchers, Shodai Komatsu and Assistant Professor Hirohisa Ohno, have developed a novel system to control gene expression in response to any.....»»
Research highlights data gap in SARS-CoV-2 cases in animals
COVID-19 in animals? The question got lost in the shuffle during the ongoing global pandemic. Research on SARS-CoV-2 has primarily focused on its implications for humans, despite the virus most likely being a zoonosis, a disease transmitted from anim.....»»
How the COVID-19 virus makes itself more infectious
Scientists at EPFL have uncovered a cunning strategy that SARS-CoV-2, the virus that causes COVID-19, uses to increase its infectivity......»»
How Cinematherapy Helped Me Through a Midlife Crisis
Yes, there is a therapeutic basis for “watching movies to heal,” but only if you do it the right way. Here's how......»»
Research explores molecular basis of ventilator-induced diaphragm weakness
A study, published in PNAS Nexus, presents evidence that mitochondrial fragmentation is a proximal mechanism underlying ventilator-induced diaphragm dysfunction (VIDD)—and identifies a possible therapeutic to limit diaphragm atrophy during a stay.....»»
Skin and gut microbiome analysis offers new therapeutic perspectives on atopic dermatitis in Shiba Inu dogs
Complex diseases—including cancer, metabolic diseases and allergies—affect not only humans, but also domestic animals, such as dogs. Approximately 10% of the dog population suffers from canine atopic dermatitis (cAD). This well-known common disea.....»»
Nanocarriers study shows antibodies against polyethylene glycol in 83% of the German population
It has long been known that people can form defenses and thus antibodies against viruses. But antibodies can also develop against polyethylene glycol (PEG), a substance used in cosmetics, food and medicine. These influence the effectiveness of drugs......»»
Broad-spectrum antiviral candidate targets dengue and SARS-CoV-2
A broad-spectrum antiviral drug candidate, 2-thiouridine, that targets positive-strand RNA viruses has been identified and characterized......»»
Enzyodynamic therapy at nanoscale
Enzyodynamic therapy (EDT) is a new type of reactive oxygen species (ROS)-related dynamic therapeutic modality, which adequately utilizes the enzyme-triggered catalytic reactions in living organisms and achieves disease treatment through controlling.....»»