SARS-CoV-2: Neutralization of BA.1 and BA.2 by therapeutic monoclonal antibodies
Scientists studied the sensitivity of Omicron BA.1 and BA.2 to nine monoclonal antibodies, some of which are used in pre-exposure prophylaxis in immunocompromised individuals. The scientists showed a loss of neutralizing activity against BA.1 and BA......»»
This year’s summer COVID wave is big; FDA may green-light COVID shots early
Wastewater SARS-CoV-2 levels suggest the summer surge is high and peaking right now. Enlarge (credit: Getty | Thomas Trutschel) With the country experiencing a relatively large summer wave of COVID-19, the Food and Drug.....»»
Advance in stem cell therapy: New technique for manipulating stem cells opens door to novel treatments
A new technique developed by McGill researchers for mechanically manipulating stem cells could lead to new stem cell treatments, which have yet to fulfill their therapeutic potential......»»
A new model to study regeneration of brown adipose tissues
The prevalence of obesity worldwide has led to an increase in the risk of metabolic diseases and socio-economical burdens. Brown adipose tissue (BAT) has been established as a promising therapeutic target to overcome obesity, type 2 diabetes (T2D) an.....»»
What shapes a virus"s pandemic potential? SARS-CoV-2 relatives yield clues
Two of the closest known relatives to SARS-CoV-2—a pair of bat coronaviruses discovered by researchers in Laos—may transmit poorly in people despite being genetically similar to the COVID-19-causing virus, a new Yale study reveals......»»
Virus that causes COVID-19 is widespread in wildlife, scientists find
SARS-CoV-2, the virus responsible for COVID-19, is widespread among wildlife species, according to Virginia Tech research published July 29, 2024 in Nature Communications. The virus was detected in six common backyard species, and antibodies indicati.....»»
New and improved drug-delivery molecules for skeletal muscle
Researchers from Tokyo Metropolitan University have created a new drug-delivery molecule, a zwitterionic polymer complex that can help get plasmid DNA inside cells when injected into skeletal muscle, a crucial step in the expression of therapeutic RN.....»»
The Highly Infectious FLiRT Variants Behind the Summer Covid Wave
The latest dominant Covid variants have stronger infectiousness than their predecessors and the ability to evade vaccine-induced antibodies......»»
Researchers identify structural characteristics of newly emerged SARS-CoV-2 variants
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to adapt to the herd immunity background and evolve into numerous sub-variants......»»
Harnessing big data helps scientists hone in on new antimicrobials
Researchers have developed a strategy to identify new antimicrobial drugs with therapeutic promise from bacterial datasets, providing clues for discovering alternatives to traditional antibiotics......»»
Researchers develop library for RNA-based therapeutic approaches with polymer nanoparticles
RNA therapy with polymer nanoparticles is considered a promising approach for the treatment of various illnesses. It involves the use of polymers as "nanocarriers" to transport RNA drugs precisely to the correct target cells. Manufacturing such polym.....»»
Understanding the role of RNA methylation in cancer
RNA modification could serve as a therapeutic target for certain types of cancer, according to a new study published in Molecular Cell, which sheds new light on the complex process underlying RNA transcription......»»
AI approach optimizes development of antibody drugs
Proteins have evolved to excel at everything from contracting muscles to digesting food to recognizing viruses. To engineer better proteins, including antibodies, scientists often iteratively mutate the amino acids—the units that are arranged in a.....»»
Exploring the molecular basis of how pradimicin A binds to viral N-glycan, a potential SARS-CoV-2 entry inhibitor
HIV, Ebola and most recently, COVID-19 viruses have had an enormous impact on our societies world-wide. All these viruses are "enveloped viruses," viruses that have an exterior envelope that surrounds them largely composed of their host's cells. This.....»»
New mRNA technology turns cells into long-lasting drug factories
A team of researchers has established a ribonucleic acid (RNA)-based method that drives cells in the body to produce therapeutic proteins and secrete them into the bloodstream. The approach could potentially extend the lifespan of drugs in the body,.....»»
A new way to see viruses in action: Super-resolution microscopy provides a nano-scale look
A new, nano-scale look at how the SARS-CoV-2 virus replicates in cells may offer greater precision in drug development, a Stanford University team reports in Nature Communications. Using advanced microscopy techniques, the researchers produced what m.....»»
Unveiling a novel AAK1 inhibitor: How chemical proteomics unlock therapeutic potential
Enhancing drug development for life-threatening diseases like cancer hinges on a deep understanding of protein kinases, making it a focal point for researchers. These enzymes, encoded by more than 500 human genes, serve as critical players in cellula.....»»
There’s New Hope for an HIV Vaccine
A trial vaccine has succeeded in generating low levels of antibodies needed to target HIV. It’s a first but much-needed step toward preventing infection......»»
Finding the chink in coronavirus"s armor—experiment reveals how the main protease of SARS-CoV-2 protects itself
The COVID-19 pandemic resulted in millions of deaths. Despite an unparalleled collaborative research effort that led to effective vaccines and therapies being produced in record-breaking time, a complete understanding of the structure and lifecycle o.....»»
Nanotubes, nanoparticles and antibodies detect tiny amounts of fentanyl
A research team at the University of Pittsburgh led by Alexander Star, a chemistry professor in the Kenneth P. Dietrich School of Arts and Sciences, has developed a fentanyl sensor that is six orders of magnitude more sensitive than any electrochemic.....»»
Developing a tech platform for fast, robust series production of nanoparticles
Nucleic acid-based medications such as mRNA vaccines offer tremendous potential for medicine and are opening up new therapeutic approaches. These active ingredients must be enclosed inside nanoparticles to ensure that they get to where they are neede.....»»