Protein structures signal fresh targets for anticancer drugs
Cell replication in our bodies is triggered by a cascade of molecular signals transmitted between proteins. Compounds that block these signals when they run amok show potential as cancer drugs......»»
New method developed to relocate misplaced proteins in cells
Cells are highly controlled spaces that rely on every protein being in the right place. Many diseases, including cancers and neurodegenerative disorders, are associated with misplaced proteins. In some cancers, for instance, a protein that normally s.....»»
Daily 5 report for Sept. 20: UAW talks with VW over first contract could be long and contentious
Experts say reaching a deal could be tricky for Volkswagen and the UAW because the two sides are starting fresh......»»
All iPhone 17 models could get big display upgrades, here’s what to expect [U]
The iPhone 16 may be fresh, but it’s never too early for details on next year’s iPhone 17 lineup. The ultra-slim iPhone 17 Air will no doubt be the highlight. But according to analyst Ross Young, there are also big display upgrades coming for the.....»»
All iPhone 17 models could get big display upgrades, here’s what to expect
The iPhone 16 may be fresh, but it’s never too early for details on next year’s iPhone 17 lineup. The ultra-slim iPhone 17 Air will no doubt be the highlight. But according to analyst Ross Young, there are also big display upgrades coming for the.....»»
Norway limits wild salmon fishing as stocks hit new lows
Norwegian authorities on Friday rolled out fresh restrictions on wild salmon fishing for 2025 after stocks hit record lows in recent years, with scientists blaming fish farms......»»
Methane is pitched as a climate villain—could changing how we think about it make it a savior?
Surging methane emissions put our ability to meet Paris agreement climate targets in jeopardy. But a timely new book presents the scientific, policy and technological challenges and solutions for achieving rapid climate gains by addressing this once.....»»
Double-edged STING: A new pathway involved in aging
A protein called STING, previously shown to control a pathway that contributes to antiviral signaling, also plays an important role in cellular stress clearance and cell survival, according to a new paper published in Molecular Cell......»»
Researchers achieve aluminum molecular ring-based rotaxane and polyrotaxane
Rotaxanes have garnered interest for their unique structures consisting of mechanically interlocked axles and macrocycles. Numerous organic macrocycles have been employed to construct rotaxanes, including crown ether, cyclobis(paraquat-p-phenylene),.....»»
Obesity-Drug Pioneers Win Prestigious Lasker Award for Medical Science
Three scientists are honored for developing a class of blockbuster weight-loss drugs. Is a Nobel prize on the way?.....»»
VW dealers get glimpse of future U.S. product
VW's U.S. sales rose 26 percent in the first half of 2024, the largest gain of any mass-market brand. VW dealers to get fresh products by year-end......»»
Plant pathogen battle: A tomato protein"s dual role in defense and susceptibility
Tomatoes, a staple crop worldwide, are increasingly threatened by biotic stressors such as viruses, fungi, and bacteria, with the effects worsening under climate change. These challenges lead to reduced yields and compromised nutritional quality, hig.....»»
Enhanced ion diffusion kinetics achieved through interpenetrated structures in electrochemical energy storage devices
As global demand for electrochemical electrodes continues to rise, a new trend has emerged, emphasizing the need to maintain ion diffusion efficiency while accommodating ultra-high loadings of active materials to enhance capacity and energy density......»»
New Sickle Cell Treatments Reach Patients after Years of Effort
The FDA recently approved three sickle cell drugs, and dozens more are in development.....»»
Researcher discusses how finger counting may help improve math skills in kindergarten
Preschool teachers have different views on finger counting. Some teachers consider finger counting use in children to signal that they are struggling with math, while others associate its use as advanced numerical knowledge. In a new Child Developmen.....»»
An unexpected protein connection in maize growth and defense could enhance crop resilience
Maize (corn) is one of the most important staple crops in the world and has been extensively studied. Yet, many aspects of the genetic mechanisms regulating its growth and development remain unexplored......»»
Team discovers naturally occurring DNA-protein hybrids
Thanks to a serendipitous discovery and a lot of painstaking work, scientists can now build biohybrid molecules that combine the homing powers of DNA with the broad functional repertoire of proteins—without having to synthesize them one by one, res.....»»
German maker of digital price tag tech targets U.S. dealers
Digital Communication Solutions developed digital price tag tech that relies in part on artificial intelligence. Prices can be changed instantly......»»
Scientists discover how TGF-Beta sends its message even while tethered to the cell membrane
For years, scientists have thought that TGF-Beta, a signaling protein that holds sway over an astonishing array of cellular processes from embryonic development to cancer, could only do its work once it escaped a lasso-like "straitjacket.".....»»
Researchers develop new method for delivering RNA and drugs into cells
Researchers at the University of Toronto and its hospital partners have developed a method for co-delivering therapeutic RNA and potent drugs directly into cells, potentially leading to a more effective treatment of diseases......»»
Symmetry model sheds light on the chemistry surrounding peptide helices
Helices are structures found naturally in many important molecules, such as proteins. These helices possess a twist that depends on the arrangement of their basic components. By understanding how a helix is formed, we can gain deeper insights into ho.....»»