Protein"s "hopping" behavior uncovers new drug development avenues
Since 2006, Ruben Gonzalez's Columbia lab has used single-molecule light microscopy to study the structural dynamics of biomolecules......»»
Analysis provides new insights into the replication of BK polyomavirus, a major cause of kidney transplant failure
BK polyomavirus, or BKPyV, is a major cause of kidney transplant failure. There are no effective drugs to treat BKPyV. Research at the University of Alabama at Birmingham reveals new aspects of BKPyV replication, offering possible drug targets to pro.....»»
Detecting problems during protein synthesis with a firefly luciferase-based reporter
A newly developed luciferase-based reporter can detect problems in protein translocation and disulfide bond formation in the endoplasmic reticulum (ER), as reported by researchers at Science Tokyo. Inspired by natural mechanisms found in bacteria, th.....»»
Method enhances solubility of pea protein for use in food and beverages
Research conducted at the State University of Campinas (UNICAMP) in São Paulo state, Brazil, shows that heat treatment of pea protein and addition of guarana extract result in a compound with significant potential to be used as an ingredient of plan.....»»
Discovery of key protein complex shows evolution and adaptability of photosynthetic organisms
A team of researchers has revealed the structure of a modified and evolved version of Photosystem I (PS I), a key protein complex used by plants and cyanobacteria to convert sunlight into chemical energy. This discovery sheds light on the evolution a.....»»
Study identifies pathways to enforce First Nation-led cultural heritage protection
A new research collaboration between the K'ómoks First Nation and Simon Fraser University highlights how Indigenous cultural heritage policies can protect archaeological sites threatened by development, given inadequate provincial heritage protectio.....»»
Spectroscopy and AI method provide unique window into protein structure and mechanism of action
The lab of Hassane Mchaourab, director of the Center for Applied Artificial Intelligence in Protein Dynamics and professor of molecular physiology and biophysics, has developed a methodological blueprint that couples experimental double electron–el.....»»
Optimal decision-making in a school of fish uses a flexible system based on role sharing, researchers find
Theoretical biology states that in a flock of birds or school of fish exhibiting collaborative behavior, being in a state of criticality (i.e., a "flexible system" that can changeably respond to the environment) is crucial for flexible and quick deci.....»»
Peer-brokered sales central to illegal drug trade
The thought of illegal drug sales evokes images of deals done on shady street corners. But a new study from Case Western Reserve University exposes a critical but underreported element of the illegal drug market: so-called "peer-brokered" sales......»»
Turning corn colorful: Researchers demonstrate purple corn"s surprising health benefits
Americans love their corn—whether it's canned, fresh off the cob or in their favorite breakfast cereal. But what if this staple grain could be more than just a starch? What if it could become a critical source of protein and fiber while helping pre.....»»
XDefiant servers are closing in June as Ubisoft announces more layoffs
Ubisoft is closing down XDefiant, shuttering two development studios, and laying off 277 people......»»
Male African elephants develop distinct personality traits as they age
Male African elephants have distinct personality traits, but also adapt their behavior to suit the social context, according to a study published December 4, 2024, in the open-access journal PLOS ONE by Caitlin O'Connell-Rodwell at Stanford Universit.....»»
A key transcription factor unlocks new potential in stem cell-based embryo models
Researchers from the A*STAR Institute of Molecular and Cell Biology (IMCB) have identified Nr1h2, a critical transcription factor essential for early embryo development. Published in Nature Communications, their findings enhance our understanding of.....»»
AI model enables reliable and accurate protein-ligand complex prediction
Understanding protein–ligand interactions is fundamental to molecular biology and biochemistry. These interactions are at the heart of many cellular processes, from enzyme catalysis to signal transduction. The foundational knowledge of protein–li.....»»
Discovery of molecular switch explains how bacteria control their protein biosynthesis through cell metabolism
Protein biosynthesis—the process whereby cells produce protein molecules, which are essential for life and growth—is a highly complex and strictly regulated affair. An interdisciplinary team led by LMU biologist PD Dr. Jürgen Lassak has now disc.....»»
Russian court sentences kingpin of Hydra drug marketplace to life in prison
The underground marketplace distributed more than a metric ton of narcotics. A Russian court has issued a life sentence to a man found guilty of being the kingpin of a dark web dr.....»»
Peat-bog fungi produce substances that kill tuberculosis-causing bacteria
An analysis of fungi collected from peat bogs has identified several species that produce substances toxic to the bacterium that causes the human disease tuberculosis. The findings suggest that one promising direction for development of better treatm.....»»
Decoding protein interactions to better understand how mutations contribute to disease
Investigating how proteins interact is key to understanding how cells work and communicate. In a new study published in Nature Communications, FMI researchers have provided key insights into how protein interactions are governed and how mutations inf.....»»
Open-source platform supports large imaging data analysis of single cell responses to manipulation
Modern day drug discovery is shifting from single end point assays to more complex phenotypic assays that query single cell and population responses to chemicals and genetic manipulation......»»
African migrants can drive growth in their home countries, but three barriers stand in the way
The idea that migration is closely linked to development has long been pervasive on the African continent......»»
Enzyme study sheds light on the molecular mechanism behind "sleepiness"
Recent research has observed that chemical modifications called phosphorylation of proteins in brain neurons dynamically regulate sleep and wakefulness. But the protein kinases that suppress sleep and the dephosphorylation enzymes that control sleep.....»»